ID A0A161SQB9_9MICO Unreviewed; 895 AA.
AC A0A161SQB9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA polymerase I {ECO:0000256|RuleBase:RU004460};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU004460};
GN Name=polA_1 {ECO:0000313|EMBL:KZE94110.1};
GN Synonyms=polA {ECO:0000256|RuleBase:RU004460};
GN ORFNames=AVP42_01321 {ECO:0000313|EMBL:KZE94110.1};
OS Agromyces sp. NDB4Y10.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Agromyces.
OX NCBI_TaxID=1775951 {ECO:0000313|EMBL:KZE94110.1, ECO:0000313|Proteomes:UP000185889};
RN [1] {ECO:0000313|EMBL:KZE94110.1, ECO:0000313|Proteomes:UP000185889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NDB4Y10 {ECO:0000313|EMBL:KZE94110.1,
RC ECO:0000313|Proteomes:UP000185889};
RA Adelskov J., Patel B.K.;
RT "Draft genome sequence of Agromyces sp. NDB4Y10 isolated from a newly
RT drilled coal seam bore well.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU004460};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZE94110.1}.
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DR EMBL; LQGY01000025; KZE94110.1; -; Genomic_DNA.
DR RefSeq; WP_067947325.1; NZ_LQGY01000025.1.
DR AlphaFoldDB; A0A161SQB9; -.
DR STRING; 1775951.AVP42_01321; -.
DR PATRIC; fig|1775951.3.peg.1353; -.
DR OrthoDB; 9806424at2; -.
DR Proteomes; UP000185889; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR CDD; cd06140; DNA_polA_I_Bacillus_like_exo; 1.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR018320; DNA_polymerase_1.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00593; pola; 1.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU004460};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU004460};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU004460};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU004460};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004460};
KW Reference proteome {ECO:0000313|Proteomes:UP000185889};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT DOMAIN 7..270
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 651..858
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 895 AA; 98042 MW; 9C7CEBC25C474390 CRC64;
MSDPTPAKPT LLVVDGHSLA YRAFYALPVD SFSTRDGQHT NAIHGFLSML LMLLRNEKPT
HLAVAFDTSR QSFRTREYTE YKANRSETPS EFKGQIGLLK EALRAMRITV LEKEDYEADD
ILATLATRGK DAGYDVLVVS GDRDTIQLVD DDITLLYPNV QGVSQLKRYD AQAVIERYGV
RPEQYPDVAA LVGETSDNLP GITKVGEKTA VKWLGLYGSL DGILEHIDEI KGVVGDNLRR
ERENAVRNRR LNRLVRDLEL DVEIADLEAK PMDEAAVREL FDRLEFKTLL ERVVKMAGEG
NGVTADGSAA LAAEPEPAAT APVSQALRGA ELEGWLARAA AAEPAGLGLS LEVLDGRVIG
AGVASSSESL QIAWTPGQAD LAPFEAWLAS DAPKIMTDAK PQLKAMRRSG LAFDGLVVDT
LVAGWLVRPS LAEKDLADLV SRYLRETIPM ADPAQLVPDA DSTAGAPEFA WYSLRVAPVV
LGALSEGSRR VLADIEIPIV GILAEMELRG VTVEHDKLAE LSAQLGERAA GLAQAAYAEI
GREVNLGSPK QLQEVLFDQL GMPKTRATKT GYSTDAGALA DLQDSNPHPF LGLLLEHRDA
TKLRQIVETL DKSIQSDGRV HTSYVQVGTT TGRISSTDPN LQNIPVRTEE GRRIRAAFTH
GADYAELLTA DYSQIEMRIM AHLSQDPGLI EAFHSGEDLH RFVGARIFDV DPSDVTPLMR
TKVKAMSYGL AYGLSAFGLS KQLRIDRAEA TQLMKDYFER FGAVRDYLRG VVAQAKVDGY
TETIFGRRRP FPDLNSPNRV LRENAERAAL NAPIQGSAAD IMKFAMIGVE RELQARDLRS
RMLMQVHDEL IFEVVAGEGD EVEALVHDRM SHAADLLVPL DVQVGRGRDW EDAAH
//