ID   A0A161UCY6_9FLAO        Unreviewed;       881 AA.
AC   A0A161UCY6;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=DNA topoisomerase IV {ECO:0000313|EMBL:KZE84848.1};
GN   ORFNames=AV926_02420 {ECO:0000313|EMBL:KZE84848.1};
OS   Myroides marinus.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Myroides.
OX   NCBI_TaxID=703342 {ECO:0000313|EMBL:KZE84848.1, ECO:0000313|Proteomes:UP000076630};
RN   [1] {ECO:0000313|EMBL:KZE84848.1, ECO:0000313|Proteomes:UP000076630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L41 {ECO:0000313|EMBL:KZE84848.1,
RC   ECO:0000313|Proteomes:UP000076630};
RA   Hong K.W.;
RT   "Whole genome sequencing of Myroides marinus L41.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KZE84848.1}.
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DR   EMBL; LQNU01000002; KZE84848.1; -; Genomic_DNA.
DR   RefSeq; WP_038985186.1; NZ_LQNU01000002.1.
DR   AlphaFoldDB; A0A161UCY6; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000076630; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KZE84848.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          35..469
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          850..881
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          349..380
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   881 AA;  100499 MW;  082ED9B48E1DCA25 CRC64;
     MSQEENLEQE LNNTNNEHQV EDFSDAQEEV TETITKVTGM YKDWFLDYAS YVILERAVPA
     IEDGFKPVQR RIMHSMKELD DGRYNKVANI VGHTMQYHPH GDASIGDALV QLGQKDLLID
     MQGNWGNILT GDGAAASRYI EARLSKFALD VLYSPKITNW QASYDGRRNE PINLPVKFPL
     LLAQGGEGIA VGLSTKILPH NFNELIDASI KILKGKPFTI YPDFPTEGIA DVSNYNDGAR
     GGRVRVRAKI APLDKNTLVI TQIPFSTTTT SLIDSILKAN EKGKIKIKKI EDNTAAQVEI
     LIHLPPGTSP DKTIDALYAF TACETSIAPL GCVIQNNRPL FTGVSEMLKN STEQTVELLR
     KELEIELNEL EEKWHFLSLE RIFIENRIYR AIEEEETWEG VLSAIDEGLK PFVKNLKRAI
     TQDDIARLTE IRIKRISRFD IDKANQNIEA LEGEIETVKF NLEHLVDFAI KYFTTLKEKY
     GKGRERLTEL RNFDTIEATK VVLRNTKLYV NREEGFFGTG LRKDEYVCDC SDIDDVIVFL
     RDGSMMVSRV DEKKFVGKDI IHIAVWDKSD KRTIYNIIYR DGKSGSSFIK RFNVTGVTRD
     KMYPLTQDKP GSQILYFSAN PNGEAEVVTI ILRQLTSVKK LKFDLDFAEL LIKGRAAKGN
     VVTKYAIKKI ELKEKGISTL RPRKIWFDET VKRLNVDGRG ELLGEFKPED RLLIVSQSGK
     VKTIIPELTT HFEEDMIVLE KWKANKPISA LYFDGEKMRY YLKRFLIENE NREELFITEH
     ANSRLEIVST DFRPVFEIVY PKVKGVQKEN QTIDVEQFIT IKGIKALGNQ ISVDKIKQVN
     ILESLAYTEE EEEEEEEEET IIIGEAPNTE IDDDGQQTLL F
//