ID A0A161WGV6_STAPS Unreviewed; 451 AA.
AC A0A161WGV6;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=HlyC/CorC family transporter {ECO:0000313|EMBL:REA83308.1};
GN ORFNames=DD902_01685 {ECO:0000313|EMBL:PWZ76750.1}, DV961_03180
GN {ECO:0000313|EMBL:REA83308.1}, EGV54_09550
GN {ECO:0000313|EMBL:EGQ4385334.1}, JGZ15_09730
GN {ECO:0000313|EMBL:QQM97742.1};
OS Staphylococcus pseudintermedius.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus; Staphylococcus intermedius group.
OX NCBI_TaxID=283734 {ECO:0000313|EMBL:REA83308.1, ECO:0000313|Proteomes:UP000256409};
RN [1] {ECO:0000313|EMBL:PWZ76750.1, ECO:0000313|Proteomes:UP000246800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST525 1 {ECO:0000313|EMBL:PWZ76750.1,
RC ECO:0000313|Proteomes:UP000246800};
RX PubMed=29292005; DOI=10.1016/j.vetmic.2017.11.018;
RA Worthing K.A., Abraham S., Coombs G.W., Pang S., Saputra S., Jordan D.,
RA Trott D.J., Norris J.M.;
RT "Clonal diversity and geographic distribution of methicillin-resistant
RT Staphylococcus pseudintermedius from Australian animals: Discovery of novel
RT sequence types.";
RL Vet. Microbiol. 213:58-65(2018).
RN [2] {ECO:0000313|EMBL:REA83308.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ST496-2 {ECO:0000313|EMBL:REA83308.1};
RX PubMed=30173756; DOI=10.1016/j.vetmic.2018.07.021;
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Methicillin-resistant staphylococci amongst veterinary personnel,
RT personnel-owned pets, patients and the hospital environment of two small
RT animal veterinary hospitals.";
RL Vet. Microbiol. 223:79-85(2018).
RN [3] {ECO:0000313|Proteomes:UP000256409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST496-2 {ECO:0000313|Proteomes:UP000256409};
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Molecular epidemiology of methicillin-resistant staphylococci amongst
RT veterinary personnel, personnel-owned pets, patients and the hospital
RT environment of two companion animal veterinary hospitals.";
RL Vet. Microbiol. 0:0-0(2018).
RN [4] {ECO:0000313|EMBL:EGQ4385334.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SPSE-18-VL-LA-PA-Ryan-0021 {ECO:0000313|EMBL:EGQ4385334.1};
RG Veterinary Laboratory Investigation and Response Network;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QQM97742.1, ECO:0000313|Proteomes:UP000595859}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HSP080 {ECO:0000313|EMBL:QQM97742.1,
RC ECO:0000313|Proteomes:UP000595859};
RA Ferrer L., Perez D., Fonticoba R., Vines J., Fabregas N., Madronero S.,
RA Meroni G., Martino P., Martinez S., Cusco A., Migura L., Francino O.;
RT "Whole genome sequencing and de novo assembly of Staphylococcus
RT pseudintermedius: a novel pangenome approach to unravel pathogenesis of
RT canine pyoderma.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UPF0053 family.
CC {ECO:0000256|ARBA:ARBA00006337}.
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DR EMBL; AAXKXX010000015; EGQ4385334.1; -; Genomic_DNA.
DR EMBL; QEIT01000010; PWZ76750.1; -; Genomic_DNA.
DR EMBL; CP066884; QQM97742.1; -; Genomic_DNA.
DR EMBL; QQPC01000014; REA83308.1; -; Genomic_DNA.
DR RefSeq; WP_014614554.1; NZ_WWPQ01000007.1.
DR AlphaFoldDB; A0A161WGV6; -.
DR GeneID; 66877366; -.
DR eggNOG; COG1253; Bacteria.
DR OMA; HGYSRYI; -.
DR OrthoDB; 9798188at2; -.
DR Proteomes; UP000246800; Unassembled WGS sequence.
DR Proteomes; UP000256409; Unassembled WGS sequence.
DR Proteomes; UP000595859; Chromosome.
DR Proteomes; UP000600220; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR PANTHER; PTHR43099:SF2; UPF0053 PROTEIN YRKA; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..203
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 222..282
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 287..344
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 451 AA; 51567 MW; C02C643E8B34CDB9 CRC64;
MDSTTILYLF IFFALIALTT VFVGSEFALV KVRASRVEQL IAEGNGNARV VKKMISNLDY
YLSACQLGIT VTSLGLGWLG EPLFERILHP VIELLNIPDA LVMTVSIVVA FTVVTYIHVV
IGELAPKSLA IQYTDRIALL YARPLYYFGL IMKPLIWLMN GSARFIIRIF GADPNAGNEA
MSEEELKIIM NNSYHGGEIN QTELAYMQNI FSFDERHAKD IMVPRTQMIT LNEPFNVDEL
LETIKEHQFT RYPITEDGDK DHIKGFINVK EFLTEYASGV PIKISNYIHE LPMISETTRI
SDALVRMQRE HVHISLIIDE YGGTAGILTM EDILEEIVGE IRDEFDDDEV NDIVKLDEQT
YQINGRVLLS DLEEMFGIVF EDSEDIDTIG GWLQAQNTDL EQDDFVDTAH DRWVISEIEN
HQIIHVLLRY EYNDSRIKNE DDEDDYLKDE S
//
