ID A0A161WLU5_STAPS Unreviewed; 207 AA.
AC A0A161WLU5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Dephospho-CoA kinase {ECO:0000256|HAMAP-Rule:MF_00376};
DE EC=2.7.1.24 {ECO:0000256|HAMAP-Rule:MF_00376};
DE AltName: Full=Dephosphocoenzyme A kinase {ECO:0000256|HAMAP-Rule:MF_00376};
GN Name=coaE {ECO:0000256|HAMAP-Rule:MF_00376};
GN ORFNames=DD902_06135 {ECO:0000313|EMBL:PWZ75130.1}, DV961_01245
GN {ECO:0000313|EMBL:REA83721.1}, EGV54_02140
GN {ECO:0000313|EMBL:EGQ4383903.1};
OS Staphylococcus pseudintermedius.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus; Staphylococcus intermedius group.
OX NCBI_TaxID=283734 {ECO:0000313|EMBL:REA83721.1, ECO:0000313|Proteomes:UP000256409};
RN [1] {ECO:0000313|EMBL:PWZ75130.1, ECO:0000313|Proteomes:UP000246800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST525 1 {ECO:0000313|EMBL:PWZ75130.1,
RC ECO:0000313|Proteomes:UP000246800};
RX PubMed=29292005; DOI=10.1016/j.vetmic.2017.11.018;
RA Worthing K.A., Abraham S., Coombs G.W., Pang S., Saputra S., Jordan D.,
RA Trott D.J., Norris J.M.;
RT "Clonal diversity and geographic distribution of methicillin-resistant
RT Staphylococcus pseudintermedius from Australian animals: Discovery of novel
RT sequence types.";
RL Vet. Microbiol. 213:58-65(2018).
RN [2] {ECO:0000313|EMBL:REA83721.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ST496-2 {ECO:0000313|EMBL:REA83721.1};
RX PubMed=30173756; DOI=10.1016/j.vetmic.2018.07.021;
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Methicillin-resistant staphylococci amongst veterinary personnel,
RT personnel-owned pets, patients and the hospital environment of two small
RT animal veterinary hospitals.";
RL Vet. Microbiol. 223:79-85(2018).
RN [3] {ECO:0000313|Proteomes:UP000256409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST496-2 {ECO:0000313|Proteomes:UP000256409};
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Molecular epidemiology of methicillin-resistant staphylococci amongst
RT veterinary personnel, personnel-owned pets, patients and the hospital
RT environment of two companion animal veterinary hospitals.";
RL Vet. Microbiol. 0:0-0(2018).
RN [4] {ECO:0000313|EMBL:EGQ4383903.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SPSE-18-VL-LA-PA-Ryan-0021 {ECO:0000313|EMBL:EGQ4383903.1};
RG Veterinary Laboratory Investigation and Response Network;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC dephosphocoenzyme A to form coenzyme A. {ECO:0000256|HAMAP-
CC Rule:MF_00376}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC EC=2.7.1.24; Evidence={ECO:0000256|HAMAP-Rule:MF_00376};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC pantothenate: step 5/5. {ECO:0000256|HAMAP-Rule:MF_00376}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00376}.
CC -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000256|HAMAP-
CC Rule:MF_00376}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REA83721.1}.
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DR EMBL; AAXKXX010000001; EGQ4383903.1; -; Genomic_DNA.
DR EMBL; QEIT01000030; PWZ75130.1; -; Genomic_DNA.
DR EMBL; QQPC01000009; REA83721.1; -; Genomic_DNA.
DR RefSeq; WP_014613685.1; NZ_WWPQ01000049.1.
DR AlphaFoldDB; A0A161WLU5; -.
DR GeneID; 66876429; -.
DR eggNOG; COG0237; Bacteria.
DR OMA; NHQAYFL; -.
DR OrthoDB; 9812943at2; -.
DR UniPathway; UPA00241; UER00356.
DR Proteomes; UP000246800; Unassembled WGS sequence.
DR Proteomes; UP000256409; Unassembled WGS sequence.
DR Proteomes; UP000600220; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd02022; DPCK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR PANTHER; PTHR10695:SF46; DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR Pfam; PF01121; CoaE; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00376}; Coenzyme A biosynthesis {ECO:0000256|HAMAP-Rule:MF_00376};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00376};
KW Kinase {ECO:0000256|HAMAP-Rule:MF_00376, ECO:0000313|EMBL:REA83721.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00376};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00376, ECO:0000313|EMBL:REA83721.1}.
FT BINDING 12..17
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00376"
SQ SEQUENCE 207 AA; 23083 MW; 7C37D47268110113 CRC64;
MPKVIGLTGG IATGKSTVAE LLAIHGFKIV DADVAARKAV AKGTEGLKKV QALFGDEAIN
EDGEMNRTFV GQQVFYDDEK RKQLNAIVHP IVGKMMNQER DQYLAEGHNV IMDIPLLFEN
HLEATVDEVW LVYASEPIQL DRLMARNDLS IEDAKARIYS QISIDKKSRM ADVVIDNLGS
KLELKQNLEQ ILVDKGFLEA YHSDSEE
//
