ID A0A162JK24_METRR Unreviewed; 1066 AA.
AC A0A162JK24;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=A-pheromone processing metallopeptidase Ste23 {ECO:0000313|EMBL:OAA43133.1};
GN ORFNames=NOR_04500 {ECO:0000313|EMBL:OAA43133.1};
OS Metarhizium rileyi (strain RCEF 4871) (Nomuraea rileyi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1081105 {ECO:0000313|EMBL:OAA43133.1, ECO:0000313|Proteomes:UP000243498};
RN [1] {ECO:0000313|EMBL:OAA43133.1, ECO:0000313|Proteomes:UP000243498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCEF 4871 {ECO:0000313|EMBL:OAA43133.1,
RC ECO:0000313|Proteomes:UP000243498};
RX PubMed=27071652; DOI=10.1093/gbe/evw082;
RA Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT "Divergent and convergent evolution of fungal pathogenicity.";
RL Genome Biol. Evol. 8:1374-1387(2016).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA43133.1}.
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DR EMBL; AZHC01000012; OAA43133.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A162JK24; -.
DR STRING; 1081105.A0A162JK24; -.
DR OMA; WIFDEMK; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000243498; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000243498};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 46..194
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 221..401
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 407..695
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 700..881
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 1066 AA; 121556 MW; E2454844D5F5ECEC CRC64;
MPSATSSGLA TSRHASVRVL TDRLEKPSID DRDYRVVRLE NELEALLVHD PQTDKASASL
SVGVGSFSDP DEMLGLAHGL EHVLFMGTEK FPGENEYSQY LSSNSGNSNA FTQSTSTNYF
FDVAAKPAND EEPSATNPSP LYGALDRFSH FFKRPLFRPD SLDRELLAVN DEHDKNLQND
NWRQYQLSGT LANPNHPFCR FTTGNLQTLK TIPESQGVNV RDKFVEFYET HYSANLMKLV
ILGREPLDVL QKWAVELFSG IKNKNLPQNR WSREPVFRDV DLGTQCFVKP VCDSRTLTLS
FPFMDGELMF KTQPGKYISH LVGHEGPGSL LSYLKCRGWV STLSAGTYDV CPGSPGIFET
EMTLTKEGLD NYAEIGKIFF QYIAMLQEAS PQEWIFEEQK RMSEVNFKYT QKTPASKFTS
STSSIMQKPL PREWLLSAQK RLRTFDASLI AECLQMLHPE KLRLTVVSQE FPGNWNKRET
WYGTEYRFEK IPQKLMAEMQ AAINMPQNKR LSELHLPHKN NFIPNKLEVE KREVSKPAVA
PRVLRNDNVA RVWWKKDDTF WVPKADVLIS LQSPIISASA ENRVKATLYT ELVVDALEEY
SYDAELAGLK YTASLDMRGI FLKLNGYNEK LPVILEKVVA TMRDLVIDEE RFRIVHDHLV
RQYENRLLQA PYHQVGGYLL WLNNQTQYSA EEMAAEFEHI NADDVRHFQK QILSQLFIEL
YAHGNLSRGD ALKLTDMVES TLKPRPLPES QWPILRSVVL PRGANFVYKK KLKNSQTINH
SIETWFYVGD QADCQLRAKT LLIHQMIDEP AFDQLRTKEQ LGYIIFANVR TICTNSGLGI
LIQSKRNPKY LDRRIESFLA QFGQMLEQMS DTEFEKHKRS LMVRLLEKPR DLDQESTKHW
KEIDLERYDF ELAQHNASNV APLAKTDVVD FYNTYLHPSS NSRSRISVHL KARGLDTKVL
EKLNSAGVRD APKEKRKSAD LLRDYLKDDG TLPSEAIDAL ISEVKKCGLP QAIETMATNG
STKDTGAIET AQVIADVRKF KASLPASSGV RPVKPINEFE ETGSKL
//
