ID   A0A162PA16_9CRUS        Unreviewed;      2896 AA.
AC   A0A162PA16;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Putative Huntingtin {ECO:0000313|EMBL:KZS18666.1};
GN   ORFNames=APZ42_015190 {ECO:0000313|EMBL:KZS18666.1};
OS   Daphnia magna.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=35525 {ECO:0000313|EMBL:KZS18666.1, ECO:0000313|Proteomes:UP000076858};
RN   [1] {ECO:0000313|EMBL:KZS18666.1, ECO:0000313|Proteomes:UP000076858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Xinb3 {ECO:0000313|EMBL:KZS18666.1,
RC   ECO:0000313|Proteomes:UP000076858};
RC   TISSUE=Complete organism {ECO:0000313|EMBL:KZS18666.1};
RA   Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT   "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in microtubule-mediated transport or vesicle
CC       function. {ECO:0000256|ARBA:ARBA00002907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the huntingtin family.
CC       {ECO:0000256|ARBA:ARBA00007153}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KZS18666.1}.
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DR   EMBL; LRGB01000512; KZS18666.1; -; Genomic_DNA.
DR   STRING; 35525.A0A162PA16; -.
DR   Proteomes; UP000076858; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR048413; Htt_C-HEAT_rpt.
DR   InterPro; IPR048411; Htt_N_HEAT_rpt-1.
DR   InterPro; IPR028426; Huntingtin_fam.
DR   InterPro; IPR024613; Huntingtin_N_HEAT_rpt-2.
DR   PANTHER; PTHR10170:SF10; HUNTINGTIN; 1.
DR   PANTHER; PTHR10170; HUNTINGTON DISEASE PROTEIN; 1.
DR   Pfam; PF20927; Htt_C-HEAT; 2.
DR   Pfam; PF12372; Htt_N-HEAT; 1.
DR   Pfam; PF20926; Htt_N-HEAT_1; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..2896
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013243950"
FT   TRANSMEM        330..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   2896 AA;  324212 MW;  9B849D862189F20E CRC64;
     MRLLIGFALV SLAVGSTFFP TEKDEVDLVS TDQNDKVSGR IAVPPPNNLR KLYSDLSTCF
     IRKIITSLLA PTSAPIRNGG IVNAAPILNP VAAPIVNTGP VGALVSGGAS QVFFSPVRIN
     IDQSSQLYVP PGTDGRITVL LKNDGVGDFF LLSGGDDKNF FIQFDYSQIQ LGPGQTLAVP
     GRIRVPQYAN NVVSTLTIIV QRRTDNAISR RQVYIRTKSE PGEKWAPWCT IRTVTQCDSY
     LDESICSSRY WNMRAEIQDT EAGLLSVSIK PDGRFLGEDF IIGTNESIAV EQSVSCCTTG
     VDITAVDVRG NTATCRADQS DSIYLSSGDV AAITLGVLLL ILLLVIIILA ICSPNVQNHK
     DFVSYIASSI DSLIRLCDSK DSDIRLASDE GLYKVIKALL PLHSNRILVE LCKQIKKSES
     PRILKLSMNR FAELCHLARR CAANAITVII STNRKSDVLL ALVVEYLTDQ ILLSEDISMT
     DTSVITGTLL TLKLLLPLFP SPFVPVKENN NHHLGSQSSK SVATMNAVAV ERIVQIFELG
     VHYSFSSDHN VVNAALELLQ QLLKMRTLLL AIPALKSANG LQGTRISLRG LSKENSQWNL
     TALPVAEESL LLEAEVHLVE FEKTNLDSTE IEVEIAEDSI ITVGRDEQDE LLKGTALTEN
     DMLPAEKDLE ETDVEQESCD VVDAPQVIDI GSLYDKTGCS PLLYCARHLS YSFLLSERKG
     QMKSDRSVRV SVKSLALNCL AHIGSLEPLI WNSYLSDSER STDGRIAIID VLQYCTHEDP
     QLRGQVSLLA CMVLSSVISG FNLTGIESKT LVRIIDETLK DREAAASRLA LQGLQHFLPM
     ALEGSFCIET TPLLRSLLKL AENPYWLVRV DLLEVFTSFS WAALEFGIKN KTSFSLPMFQ
     EAFLRKVAFT MIGDEDQRVR SAVANCIKCS VESWTTTKSP PSVVRLKSLA SACNFSHQKL
     SSKTFAGVPL SINGLAEAYC DGPVNGNVVE NLACFIDELY KLLVSSNSKF VKMGCLQALA
     ELSRSYPPAT YMEIYGCSPK GTCSLLKVCI ALMTNSTLML DLANHQSLIT LSTQLFAGCV
     KVDLNAPESE IEDKEWHFLT GPLATIASHL LSHISRILNA FCCVLEDVNP LSVSIKAPLV
     TLPNPSALSP IRRKLRNSEG PILDKEDKSD EFARKSKPHI LNPSNIGFFA SQSLYVKFYE
     LLKSTNATCK LNFDTVTSER LSSFIQSTLK ALAALVEVYN FQDIGKHSEE VLNYLRIIIT
     AEPVYCLQAV QQLLKALFGT NLAAVWYDEA SRFKRGCISP NFSVTMKKDK SMSLSYGFDD
     YLYRDTVRQM TFNLTGERPS LITKFRTSVN KIGPDKTALT SYIRLFEPMV IKALKLYTVT
     SCPHVQKQVL DLLCELIHLC VNYCLLDADQ VFLNFVIQQF EFLEEGFIPQ VETLLPSMFR
     FLSLLSYDRF HSKTIISVPR IMQLAGGLMA TGKDAELHVL PTLRPMVEDL FLSRERMSDN
     FKELETQKEV LINILLRLLQ YHKVYPLITA ILLQVQFENA SKWKSLSKQI CDALIPHLNK
     HSLFLDSDEA LQMLYKLISH MDPPVVHESL LGLLQTFTPK QSEDLNSSAT SNYHRVLACR
     LTVFKTLISV FDEAFLLDCL NEFNLSYLVN QRSDPLNVTP TENSPPDHIL SSLLVDTLKL
     AFSHWKSKSF ADSCGSTSIS WKIDGFSFSV HLVLDLIALC RQLVNAEDFP VLRTAIRAEL
     ARDECKYPLF EVARELIPNN PIVFARVCAL LAPEIHCFEA DDMQQFFTGL NGSIAEAGYF
     LVLPGIMPKQ EEKLKAFVSV HADLILSYSS ETPVKKFFQN LVVDENLIKP LVKCVLAKSG
     LSLVAAAVSL FNIIEALQIA NVEEILLEVI SSFQSLSNGV VHKKLERLLL KMNFSSAESQ
     LQCLEKAQEI ILQSKNERWY SELMTKHRAS LAYIPEMLRK IDKAFLLEFA LSRNLKPIMW
     QEIVTQIHLD DLPGWFSNYS FLSFALGTGR KSKPDIFVRA KTYFLNMIDT TVFDNIKILP
     IARILSGMCK TIQPSELKDI FTPLEISILA RVSLTFMAAM DSLQRSLVLL PASSAIVSIF
     CLELPSVWTN KETLPAVYKA IDALESLCIR LRNNTTFEHP SVTGLEHMNC PDPNFVSSAQ
     QLSRIVTFLE QETHIPEVLH KDFLLIAIAF CRMPLFYSYT CIPPSVWNKG WNPVLAFDVE
     RITFDLPIVP SYFLHDEVVL KEFIFRIERI CWITKKKFEE IWMTFLGILN LQNEDNVRPE
     EQASVIQATC EAVHALTMVL QKNLPYRTSH TAPRANNLDE IPDFMHTELV KLRGKKLKEL
     CNLLGDDCDV PSSCNSIYYF NRLSFRHIQR SIDQGSPSKK KAVSPEEITD IDIQSCVRFL
     VDLYSQWLQS STTPYPLLVD IFRSLLHISD FFVDAQQFEW LLDNSFALYK QLLPDDPTSL
     ESALTGCILK SASFTTLNSE YWDLIRKHCE ASLYSQHIST RASGLDGLLY LLQKLARNPD
     LARTGSLVNL AMDYVGKWLN AENSGPTWYQ SVVWSMAFYC GEHFAVLPYQ HNAVVDFVVQ
     CAIGWLAQNQ QQPTEIQKEI LQGLERLSVL GLLTPTWRFT VKREILAIIR NVDRDQILKG
     ALRTLLSLVY SDFGSQLYQP GADPETMLAA MEWVGALFQR MKRGTDREAE ILGQIMPVIT
     CDIFPPADIL NRILSEFITA RPSVACCLTP TIFKVFGTAR SQGQQSLVVE WILLSLSNFT
     RSLSDESANS VWNVLCFFTA ASSNPWLQSV FPLVNQPVNP KNPMEVEIFV ASALDFRNQL
     DDQQRSTLVS IFFSARDNSS FFAAVDVALK GKTYSWRMIH LFLVTSSVKQ MVNWQTPIHR
     ACVIDDIHSG HDCVVN
//