ID A0A162TMG1_9CLOT Unreviewed; 646 AA.
AC A0A162TMG1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=DNA polymerase I, thermostable {ECO:0000313|EMBL:KZL92831.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:KZL92831.1};
GN Name=polA_4 {ECO:0000313|EMBL:KZL92831.1};
GN ORFNames=CLMAG_26450 {ECO:0000313|EMBL:KZL92831.1};
OS Clostridium magnum DSM 2767.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121326 {ECO:0000313|EMBL:KZL92831.1, ECO:0000313|Proteomes:UP000076603};
RN [1] {ECO:0000313|EMBL:KZL92831.1, ECO:0000313|Proteomes:UP000076603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2767 {ECO:0000313|EMBL:KZL92831.1,
RC ECO:0000313|Proteomes:UP000076603};
RA Poehlein A., Uhlig R., Fischer R., Bahl H., Daniel R.;
RT "Genome sequence of Clostridium magnum DSM 2767.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZL92831.1}.
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DR EMBL; LWAE01000002; KZL92831.1; -; Genomic_DNA.
DR RefSeq; WP_066622594.1; NZ_LWAE01000002.1.
DR AlphaFoldDB; A0A162TMG1; -.
DR STRING; 1121326.CLMAG_26450; -.
DR PATRIC; fig|1121326.3.peg.2655; -.
DR OrthoDB; 9764911at2; -.
DR Proteomes; UP000076603; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08642; DNA_pol_A_pol_I_A; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:KZL92831.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000076603};
KW Transferase {ECO:0000313|EMBL:KZL92831.1}.
FT DOMAIN 370..612
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 646 AA; 72928 MW; 67142BA21D4B034A CRC64;
MKSISIDIET FSSENLQKSG VYRYAESRDF EISLFGYSVD GGEAQVVDLA CGEEVPDEII
DALIDDSVTK WAFNAMFERV CLSKWLNLPL GEYLDPASWK CSMIWSAYMG LPLSLEGVGT
VLGLEKQKLT GGKDLIRYFC TPCSPTKSNG GRNRNLPEHD TDKWECFKAY NLRDVETEMA
IKQRLSKFPM PENVWEEYRL DQEINDRGIS IDMTFVKQAV AIDENSREKL TALMQDMTNL
ENPNSVQQMK GWLADNGMET DTLGKKAVVE MLKTAPEPLS EVLELRQQLA KSSVKKYTAM
ENAVCHDGRA RGMFQFYGAN RTGRFSGRLI QLQNLPQNHM PDLEQARDLV RSGNFDALTF
LYDSIPEVLS ELIRTAFIPR DGKKFIVADF SAIEARVIAW LAGEKWRMEV FQNGGDIYCA
SASQMFHVPV EKHGVNGHLR QKGKISELAL GYGGSVGALK SMGALEMGIE EDELQPLVTA
WRQTNPNITE LWWDVDRAVK TCVKQKTPTE THGIKFTYQS GMLFITLLSG RQLSYVKPRM
GENIFGGESV TYEGVGGMKK WERIESYGPK FVENIVQAIS RDILCYAMQT LKNCFIVAHV
HDEIIIETDM RMSLSAVCEQ MARTPTWAKG LLLSADGYEC QFYKKD
//
