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Database: UniProt
Entry: A0A162UJ84_PHYB8
LinkDB: A0A162UJ84_PHYB8
Original site: A0A162UJ84_PHYB8 
ID   A0A162UJ84_PHYB8        Unreviewed;       371 AA.
AC   A0A162UJ84;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=PHYBLDRAFT_180150 {ECO:0000313|EMBL:OAD76602.1};
OS   Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 /
OS   NBRC 33097 / NRRL 1555).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX   NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD76602.1, ECO:0000313|Proteomes:UP000077315};
RN   [1] {ECO:0000313|EMBL:OAD76602.1, ECO:0000313|Proteomes:UP000077315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG   DOE Joint Genome Institute;
RA   Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA   Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA   Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA   Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J.,
RA   Gutierrez G., Heitman J., Henrissat B., Iturriaga E.A., Lang B.F.,
RA   Lavin J.L., Lee S., Li W., Lindquist E., Lopez-Garcia S., Luque E.M.,
RA   Marcos A.T., Martin J., Mccluskey K., Medina H.R., Miralles-Duran A.,
RA   Miyazaki A., Munoz-Torres E., Oguiza J.A., Ohm R., Olmedo M.,
RA   Orejas M., Ortiz-Castellanos L., Pisabarro A.G., Rodriguez-Romero J.,
RA   Ruiz-Herrera J., Ruiz-Vazquez R., Sanz C., Schackwitz W., Schmutz J.,
RA   Shahriari M., Shelest E., Silva-Franco F., Soanes D., Syed K.,
RA   Tagua V.G., Talbot N.J., Thon M., De Vries R.P., Wiebenga A.,
RA   Yadav J.S., Braun E.L., Baker S., Garre V., Horwitz B.,
RA   Torres-Martinez S., Idnurm A., Herrera-Estrella A., Gabaldon T.,
RA   Grigoriev I.V.;
RT   "Expansion of signal transduction pathways in fungi by whole-genome
RT   duplication.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; KV440975; OAD76602.1; -; Genomic_DNA.
DR   RefSeq; XP_018294642.1; XM_018438271.1.
DR   GeneID; 28999177; -.
DR   OrthoDB; 1034517at2759; -.
DR   Proteomes; UP000077315; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077315};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077315};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361}.
FT   DOMAIN       55    354       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   371 AA;  40459 MW;  945D1A9B6DAD41B8 CRC64;
     MSNLTRTVYH EALNELDDKR IKCIKPLIPP QILMEDIPLT LKAAQTIVEG RRGAENIIRG
     SDDRLLVVVG PCSIHDVKAA KEYAVKLIEY AETAKDDLLI IMRVYFEKPR TTVGWKGLIN
     DPYLNNSYEI NKGLRIARQL LLDLNEMGVP TGCEFLDTIS PQYTGDLVSW GAIGARTTES
     QIHRELASGL SCPVGFKNGT DGGITVAMDA IKAASNGHHF LSVTKQGLSA IVQTEGNEAC
     HVILRGGKSG PNYSAEDIEI CAKALQKAKL SSNIMVDCSH GNSSKDHNRQ PIVAQSIASQ
     LAEPKKTGDN IVGVMIESHL VEGRQDIPNE GPHRLVYGQS VTDACINWDA TVKTLDTLKE
     GVRARRAARQ A
//
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