ID A0A162XC13_PHYB8 Unreviewed; 1392 AA.
AC A0A162XC13;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=PHYBLDRAFT_177538 {ECO:0000313|EMBL:OAD73845.1};
OS Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC
OS 33097 / NRRL 1555).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD73845.1, ECO:0000313|Proteomes:UP000077315};
RN [1] {ECO:0000313|Proteomes:UP000077315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA McCluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
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DR EMBL; KV440980; OAD73845.1; -; Genomic_DNA.
DR RefSeq; XP_018291885.1; XM_018437900.1.
DR STRING; 763407.A0A162XC13; -.
DR GeneID; 28998806; -.
DR VEuPathDB; FungiDB:PHYBL_177538; -.
DR InParanoid; A0A162XC13; -.
DR OrthoDB; 169836at2759; -.
DR Proteomes; UP000077315; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02736; RNAP_III_Rpc1_C; 1.
DR CDD; cd02583; RNAP_III_RPC1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR035698; RNAP_III_Rpc1_C.
DR InterPro; IPR035697; RNAP_III_RPC1_N.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000077315};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 243..545
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1392 AA; 155743 MW; FC937AE1C3951045 CRC64;
MKEQVNDNTP KRIRHIQFGV MSPQNMVKIS EFEITQRDLY QPESRTPVKG GVLDLRLGTS
NKEAVCDTCG QKMQECPGHW GYLKLVLPIF HIGYFRPVIN ILQDICKSCS RVMLEEPERR
SFLRRLRAPG LDNLTRGRVI KAINDRCKRV TFCPHCKATN GVVKKVGPMK ITHDKYRLKR
VAEEAEQFRK TFENATNAMP ELKAHLSKAQ DDLNPLRVLR LFQRITPEDC ELLGLSEEHG
RPEWYIWQYL PVPPSCIRPS VMQDDNSSNE DDLTAKLTEI IFTNAIIRAG LERGVTVMNL
MEQWEFLQLA AAMYINSEMP GVPNANAGKP SRGLCQRLKG KQGRFRGNLS GKRVDFSGRT
VISPDPNMRI DQVAVPERVA KILTFPERVH AHNIHKLRQN VINGPDVHPG ANYVTFADGY
KKFLKFGDRN NIAAELKIGD LVERHMSDND VVLFNRQPSL HRLSIMAHFA KIMPWRTFRF
NECVCSPYNA DFDGDEMNMH LPQTQEAKAE AIELMGVKNN LVTPRNGEPL IAATQDFITA
SYLLSHKDTF YSRAMFTQVC TMMGDGEMNI DLPPPVIWKP QRLWTGKQVF NILFRPNKES
KVQLNVEAKT KSYEKQEGRV PDLCPNDGWL IVQDSEIMCG LVDKAVVGDG NKNSVFYVIL
RDYGPIEAAK CMNRLAKLCA RYLANQGFSI GISDVTPGKR LREIKQAEVQ EAYRKCDEII
AKYKSGQLET MAGCDEEQTM ESTVSGILSA VRGDLGKVCM TELNMYNSPS IMARCGSKGS
QINVSQMVAC VGQQIISGSR IPDGFQDRSL PHFLKHSKSP PAKGFVRNSF FTGLSPTEFL
FHAVSGREGL VDTAVKTAET GYMARRLMKA FEDLTTHYDL SVRNSEGAML QFRYGADGLD
PMTIEGDGIP VEFERNLKHV KICTPLNGEE GLLPWQIIKL AEDVTSQDVW TTNCMQSFID
MVLTFINDKV AGKLANLRKK HGMLPGLSIP DEDYMDMDID EDVPEATKHA LRNMCVVTER
QLRDYLGVCL SKYLKAKIEP GTAVGAIGAQ SIGEPGTQMT LKTFHFAGVA SMNITLGVPR
IKEIINAAKV ISTPIITCDL HSDKDVRAAR VVKGRVEKTT LGDVAMYMEE VYEPNDTHIL
LRIDLDALNK LQLETNIYEI ATAIQTAPKL KSSQLDVQTS RPDIIRVYVH AKQDESMYYS
LKAIKRLLCA VIIKGLPSVV RAVISEKAGG SGSKQLLVEG YGLLDVMTTD GIIGENTTSN
HIMEVAQVLG IEAARNTIIR EIQVTMESHG MTIDHRHVFL LGDIMTSKGE VLGITRFGIS
KMRDSVLSIA SFEKTTDHLF EAALYSKCDA VVGVSEQIIM GIPMSIGTGL FKLIHQPSQP
DIPKPKPLLF DI
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