ID A0A163D9B9_PHYB8 Unreviewed; 884 AA.
AC A0A163D9B9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Histidine-specific methyltransferase SAM-dependent domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYBLDRAFT_127007 {ECO:0000313|EMBL:OAD69710.1};
OS Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC
OS 33097 / NRRL 1555).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD69710.1, ECO:0000313|Proteomes:UP000077315};
RN [1] {ECO:0000313|Proteomes:UP000077315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA McCluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00037882}.
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DR EMBL; KV440991; OAD69710.1; -; Genomic_DNA.
DR RefSeq; XP_018287750.1; XM_018429139.1.
DR AlphaFoldDB; A0A163D9B9; -.
DR STRING; 763407.A0A163D9B9; -.
DR GeneID; 28990045; -.
DR VEuPathDB; FungiDB:PHYBL_127007; -.
DR InParanoid; A0A163D9B9; -.
DR OrthoDB; 1416at2759; -.
DR Proteomes; UP000077315; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR024775; DinB-like.
DR InterPro; IPR019257; MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR InterPro; IPR005532; SUMF_dom.
DR InterPro; IPR042095; SUMF_sf.
DR NCBIfam; TIGR03439; methyl_EasF; 1.
DR PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR Pfam; PF12867; DinB_2; 1.
DR Pfam; PF03781; FGE-sulfatase; 2.
DR Pfam; PF10017; Methyltransf_33; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000077315};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 55..367
FT /note="Histidine-specific methyltransferase SAM-dependent"
FT /evidence="ECO:0000259|Pfam:PF10017"
FT DOMAIN 440..596
FT /note="DinB-like"
FT /evidence="ECO:0000259|Pfam:PF12867"
FT DOMAIN 682..776
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
FT DOMAIN 808..882
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
FT REGION 25..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 100079 MW; 0222BA729E003B52 CRC64;
MLPRSLSPST YELLDIRAPD HTTLKKSKEA PLVGRPPSPP SSEASLDVFS SAELANTILE
GLRKPTHKKS ISTFVLYDNR GLNLFDKITY QEDYYLTNAE LDILQQRADE LADRLHDGSV
LIELGAGALR KTQLVLQAIE RKKLRVTYYA LDLDQHELER SLGKLGEFCY VKLMGLLGTY
DQGIPWLSEH FKDTNTHKAI MWLGSSIGNQ NRRESAIFLR RLQRTCLQPG DICVIGFDLR
NDPAKIQAAY DDKDGITREF ILNGLDHVNA ILGQNILDRK DFAYDSRYQT GHGRHVAHYR
ALRDMGLVYH SKSGDVKIEL SKDELIHIEH SYKYSLKETT HILESAELNM LENWTDSKHQ
YRLVVAECRP FSFGGDRNAI IHTLFPPENA YPQDVISCDT CNDTGIDPSV ASNTLPNLVG
PLHWPEFLPS LYEWEQLWKS WDTVTAIIRN QPSMLHEKPI KFRHPCIFYL GHIPAFLDIQ
LSRNAIDQDI NPEHLLTEPA VFADIFERGI DPDMDDPSKC NPHSTVPTEI NGWPLLDDIM
TYQKAIRARL ERLLISWEVQ FQTAGANGNW PSTVTKRKQR IMHMTFEHEA MHLETLLYML
VQSPNVRPPP GVGLPDWKMA EISASFASQF SAKKCLDSAP MLEMKAGSVV LGHEDDESSD
WTPMDGAPVN ALESTTTHGL TSFGWDNEHP CRVVRVSAFS IQSRPVTNGE YLAKLGNRPL
PESWGRIAGQ DVIGVKTVFG LCPMKYCMDW PVQVSAAEAE VYASLMGMRL PTEAELVMFR
KSAKSERIPN IGFGEWSPTA LRNDEIHIVG DVWELTGTIL ESHEGYNPST IYLGYSSDFL
DGKHRVVLGG SWATHPRISC RETFRNWYQA SYPFVFSGFR LCRS
//
