ID A0A163JD38_DIDRA Unreviewed; 1481 AA.
AC A0A163JD38;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=ST47_g2590 {ECO:0000313|EMBL:KZM26286.1};
OS Didymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella
OS rabiei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Didymellaceae; Ascochyta.
OX NCBI_TaxID=5454 {ECO:0000313|EMBL:KZM26286.1, ECO:0000313|Proteomes:UP000076837};
RN [1] {ECO:0000313|EMBL:KZM26286.1, ECO:0000313|Proteomes:UP000076837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ArDII {ECO:0000313|EMBL:KZM26286.1,
RC ECO:0000313|Proteomes:UP000076837};
RX PubMed=27091329; DOI=10.1038/srep24638;
RA Verma S., Gazara R.K., Nizam S., Parween S., Chattopadhyay D., Verma P.K.;
RT "Draft genome sequencing and secretome analysis of fungal phytopathogen
RT Ascochyta rabiei provides insight into the necrotrophic effector
RT repertoire.";
RL Sci. Rep. 6:24638-24638(2016).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZM26286.1}.
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DR EMBL; JYNV01000110; KZM26286.1; -; Genomic_DNA.
DR STRING; 5454.A0A163JD38; -.
DR Proteomes; UP000076837; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000076837};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1481
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007843278"
FT TRANSMEM 1355..1379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1411..1432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..666
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 710..1347
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 643..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1451..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1481 AA; 166474 MW; CD5012B09AEE3BE9 CRC64;
MRYNAGLLLP ALLALAPSIA AKKETPLVET TAFKNEIVNI LYFDDSAVAL LQELESGRIW
RSKDAGKGWK REEEMNGNGI LKSPYDNNVA TVLGETKHWI TYDQGENWSS FKTELPPSPE
APLSWHATDP KKILINEIDN CFTAPCLGRT YYTTDGFKSE PKLLIEDRRM CQWAKGSERF
LMDSDKHDDR ILCITRGKYS DRTKDFRLLT SDNYFKDFDE PVMSSGRTVQ GMANMAAVKG
YIVAAAKADH SSELTLYVTT DTDTWHHAEF GDHKVEQDAY TILESTNYSI QVDVMTSKYT
AMGTLYTSNS NGTYFTKNVE HMNRNERGFV DFEKIANIQG VVMVNLVDNW KDYEKKGSPK
KLKSKISFDD GRTFEKLEVK GKDKDLHLHS VTDLHNSGRV FSSLAPGMVM GVGNTGDQLG
KYTDGDLYVS DDAGLTWELA LEEAHKYEFG DQGSILVAVY DEGDTDKVMY SLKHGRKNTW
KEIDVGYKFR ARELTTLPDS TSQKFMLYAS KKKDGGGREH VIIHLDFSEL HERKCGEKDF
EDWSVRKEDD GKPSCVMGHK QLFKRRKWDA DCFVSEPFKD PTPRFEPCEC DAVRDYECDV
NFTPNGEGKE MKCEPSDQVR LPAGACKGDD KTYKGSSGWR KIPGNQCKGE TERDREVERP
CGDAERPPPK SDKITSEITK FKGSNFMEHY YLERDAQNRD DSDNARDRDE TIVLLTSERE
AYITHDHGKK WKKAVDDEIV RIYPHTYENN YVYFLTASKK VYYSEDRGLK DSIHSFEAPV
MPNTQLLQIL QFHPKQKGWL IWLGGEHCEK LGDKDCHTVS YVSQKNGVSG SWEAMLPYVK
KCAFVWREAG RDVKEERVFC EQYTKEEMGA PVELISSDDW FKKKDVKFES VVEFATMSEF
IIVATKGKDG KSLELSASLD ANIFAEAKFP PKFAVDHQTA YTVLDSSTHA IFLHVTVNPR
PDQEYGSIIK SNSNGTSYVM SLNGVNRNTE GYVDFEKMQG LEGVALANII ANVDEVNKGT
KKRKQTRITH NDGAEWAPLD APEKDSDGKS YSCDVSNPAK CSLHIHGYTE RSDPRETYSS
PTAVGLMLGV GNVGSELATL GESSTFMTTD AGITWKEIKK GAYAWEFGDQ GSVIVIVRRG
EDTDHLYYSL DSGDKWTLYK FAEHAVRIDA ITTVPSDTSL NFLLWGKDGK ELVAINVDFS
GLEEFSKKCN LDEKNPGSGD YDLWTPQHPM QQDQPECLFG HVAEYHRKKR DARCRNGERI
DHMHEIARNC TCTRRDFECA YNYERQPGGE CTLIPGLTLE DPKAVCSKGA REYWDNSAFR
KIPLSTCEGG QEFDHVGAPH PCPGFEEEFQ KKHGIGGFAL FLAIVLPFAA AGGIGYYVWR
NWNGIGKFGA IRLGDSGGGF NSDAPWVKYP VAVVSGLVAI IAAIPMLVGS LWRMVSGGRG
GGGYGGRTYT SRSSFSRGRG DYAVVDPDEG ELLGDESDEE V
//
