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Database: UniProt
Entry: A0A163VIX5_9BACT
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ID   A0A163VIX5_9BACT        Unreviewed;       213 AA.
AC   A0A163VIX5; A0A163VC56;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   08-MAY-2019, entry version 15.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=AO394_05850 {ECO:0000313|EMBL:KZD17300.1}, AO396_03005
GN   {ECO:0000313|EMBL:KZD17647.1};
OS   Candidatus Fermentibacter daniensis.
OC   Bacteria; Candidatus Fermentibacteria;
OC   Candidatus Fermentibacteria (class); Candidatus Fermentibacterales;
OC   Candidatus Fermentibacteraceae; Candidatus Fermentibacter.
OX   NCBI_TaxID=1729713 {ECO:0000313|EMBL:KZD17647.1};
RN   [1] {ECO:0000313|EMBL:KZD17647.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dam_1 {ECO:0000313|EMBL:KZD17300.1}, and Vib_1
RC   {ECO:0000313|EMBL:KZD17647.1};
RX   PubMed=27058503;
RA   Kirkegaard R.H., Dueholm M.S., McIlroy S.J., Nierychlo M., Karst S.M.,
RA   Albertsen M., Nielsen P.H.;
RT   "Genomic insights into members of the candidate phylum Hyd24-12 common
RT   in mesophilic anaerobic digesters.";
RL   ISME J. 0:0-0(2016).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KZD17647.1}.
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DR   EMBL; LKHB01000194; KZD17300.1; -; Genomic_DNA.
DR   EMBL; LKHD01000150; KZD17647.1; -; Genomic_DNA.
DR   EnsemblBacteria; KZD17300; KZD17300; AO394_05850.
DR   EnsemblBacteria; KZD17647; KZD17647; AO396_03005.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070209};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070206};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070211};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070205};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070204}.
FT   DOMAIN       11    191       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
FT   NP_BIND      13     20       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   213 AA;  23018 MW;  3FC89380F3414D18 CRC64;
     MRRPGGLFVT FEGVEGAGKT TRSAALAGSL RSIGFEVVHT REPGGPPLAE AIRRLLLDPS
     LEIPTAAELM LYLASRASNV EHIVRPALAA GGVVICERFN DATEAYQAAG RGLDREFVES
     ACSFATGGLE PDLTVLLDLD PAEGMARLDS RPGGPDRIER EDLAFHARVR EEYLSLARRH
     RRFRVLDASL PGCEIDGIVL GLVEEALRVK EST
//
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