ID A0A164AKE8_9BRAD Unreviewed; 158 AA.
AC A0A164AKE8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Transcription elongation factor GreA {ECO:0000256|ARBA:ARBA00013729, ECO:0000256|HAMAP-Rule:MF_00105};
DE AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN Name=greA {ECO:0000256|HAMAP-Rule:MF_00105,
GN ECO:0000313|EMBL:NUU42850.1};
GN ORFNames=A4A58_00175 {ECO:0000313|EMBL:KZD24947.1}, HB776_19390
GN {ECO:0000313|EMBL:QND73129.1}, HP556_17180
GN {ECO:0000313|EMBL:NUU42850.1};
OS Tardiphaga robiniae.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Tardiphaga.
OX NCBI_TaxID=943830 {ECO:0000313|EMBL:KZD24947.1, ECO:0000313|Proteomes:UP000076574};
RN [1] {ECO:0000313|EMBL:KZD24947.1, ECO:0000313|Proteomes:UP000076574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Vaf07 {ECO:0000313|EMBL:KZD24947.1,
RC ECO:0000313|Proteomes:UP000076574};
RA Kopat V., Chirak E., Kimeklis A., Andronov E.;
RT "Microsymbionts genomes from the relict species Vavilovia formosa (Stev.)
RT Fed.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000515291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=581 {ECO:0000313|Proteomes:UP000515291};
RX PubMed=32686981;
RA Safronova V., Guro P., Sazanova A., Kuznetsova I., Belimov A., Yakubov V.,
RA Chirak E., Afonin A., Gogolev Y., Andronov E., Tikhonovich I.;
RT "Rhizobial microsymbionts of the narrowly endemic Oxytropis species growing
RT in Kamchatka are characterized by significant genetic diversity and possess
RT a set of genes that are associated with T3SS and T6SS secretion systems and
RT can affect the development of symbiosis.";
RL Mol. Plant Microbe 33:1232-1241(2020).
RN [3] {ECO:0000313|EMBL:QND73129.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=581 {ECO:0000313|EMBL:QND73129.1};
RX PubMed=33272987;
RA Hatmaker E.A., Presle G., Cannon O., Guss A.M., Elkins J.G.;
RT "Complete genome sequences of four natural Pseudomonas isolates that
RT catabolize a wide range of aromatic compounds relevant to lignin
RT valorization.";
RL Mol. Plant Microbe Interact. 9:1232-1241(2020).
RN [4] {ECO:0000313|EMBL:NUU42850.1, ECO:0000313|Proteomes:UP000570860}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 26467 {ECO:0000313|EMBL:NUU42850.1,
RC ECO:0000313|Proteomes:UP000570860};
RA Lemaire J.F., Inderbitzin P., Gregorio O.A., Collins S.B., Wespe N.,
RA Knight-Connoni V.;
RT "Genome Sequencing of Type Strains.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by cleavage factors such
CC as GreA or GreB allows the resumption of elongation from the new
CC 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC {ECO:0000256|ARBA:ARBA00024916, ECO:0000256|HAMAP-Rule:MF_00105,
CC ECO:0000256|RuleBase:RU000556}.
CC -!- SIMILARITY: Belongs to the GreA/GreB family.
CC {ECO:0000256|ARBA:ARBA00008213, ECO:0000256|HAMAP-Rule:MF_00105,
CC ECO:0000256|RuleBase:RU000556}.
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DR EMBL; LVYV01000001; KZD24947.1; -; Genomic_DNA.
DR EMBL; JABMCJ010000085; NUU42850.1; -; Genomic_DNA.
DR EMBL; CP050292; QND73129.1; -; Genomic_DNA.
DR RefSeq; WP_068728727.1; NZ_LVYV01000001.1.
DR AlphaFoldDB; A0A164AKE8; -.
DR STRING; 943830.A4A58_00175; -.
DR KEGG; trb:HB776_19390; -.
DR OrthoDB; 9808774at2; -.
DR Proteomes; UP000076574; Unassembled WGS sequence.
DR Proteomes; UP000515291; Chromosome.
DR Proteomes; UP000570860; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.50.30; Transcription elongation factor, GreA/GreB, C-terminal domain; 1.
DR Gene3D; 1.10.287.180; Transcription elongation factor, GreA/GreB, N-terminal domain; 1.
DR HAMAP; MF_00105; GreA_GreB; 1.
DR InterPro; IPR036953; GreA/GreB_C_sf.
DR InterPro; IPR018151; TF_GreA/GreB_CS.
DR InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR NCBIfam; TIGR01462; greA; 1.
DR PANTHER; PTHR30437; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR PANTHER; PTHR30437:SF4; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR Pfam; PF01272; GreA_GreB; 1.
DR Pfam; PF03449; GreA_GreB_N; 1.
DR PIRSF; PIRSF006092; GreA_GreB; 1.
DR SUPFAM; SSF54534; FKBP-like; 1.
DR SUPFAM; SSF46557; GreA transcript cleavage protein, N-terminal domain; 1.
DR PROSITE; PS00829; GREAB_1; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00105}; Elongation factor {ECO:0000313|EMBL:KZD24947.1};
KW Protein biosynthesis {ECO:0000313|EMBL:KZD24947.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000076574};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00105};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00105}.
FT DOMAIN 5..75
FT /note="Transcription elongation factor GreA/GreB N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03449"
FT DOMAIN 83..156
FT /note="Transcription elongation factor GreA/GreB C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01272"
SQ SEQUENCE 158 AA; 17218 MW; 9CC06445B2FCA5C2 CRC64;
MVEKVPMTAG GYAALEVELK ERQSVHRPRI IEQIAEARSH GDLSENAEYH AAKEEQSHNE
GRISDIEDKL ARADIIDISK LSGDTIKFGA TVTLIDEDTE KKAVWQIVGE PEADAKKGRI
SITSPLARAL IGKSKGASVE VVAPGGAKAY EITKVEWR
//
