ID A0A164MPJ6_9AGAM Unreviewed; 528 AA.
AC A0A164MPJ6;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
GN ORFNames=SISNIDRAFT_491528 {ECO:0000313|EMBL:KZS86906.1};
OS Sistotremastrum niveocremeum HHB9708.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Trechisporales; Trechisporales incertae sedis; Sistotremastrum.
OX NCBI_TaxID=1314777 {ECO:0000313|EMBL:KZS86906.1, ECO:0000313|Proteomes:UP000076722};
RN [1] {ECO:0000313|EMBL:KZS86906.1, ECO:0000313|Proteomes:UP000076722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB9708 {ECO:0000313|EMBL:KZS86906.1,
RC ECO:0000313|Proteomes:UP000076722};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000256|ARBA:ARBA00005248}.
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DR EMBL; KV419463; KZS86906.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A164MPJ6; -.
DR STRING; 1314777.A0A164MPJ6; -.
DR OrthoDB; 1607026at2759; -.
DR Proteomes; UP000076722; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1.
DR PANTHER; PTHR31382:SF4; NA(+)_H(+) ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000076722};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..428
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 474..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 56862 MW; 1A0C59ACECA2CFAD CRC64;
MTIQLVEVTT ANLTYLCLGG FIVAFTTVAL LVREKAWQLY LGECVLATAF GIAIGPSGGN
IFNPRSWGDI NDITLEVMRI VLATGVFSIG VELPKAYMLV NWKSLVFMIV PTMTFGWFIS
AGLIVALFPA LNFRSALVIS ACLTPTDPIL AMAIIMGKFA VKHVPKHLRL LLAAESAAND
GLAYPFLTLP LYLTLEATTG SAVGKWLLVG CLYQVILGTV IGAVAGSAFR YLLRFNQNRG
FIDHESFVAQ YLALAVFVVG FCNIIGSDDL LAAFAAGTAI SWDGDFNAQT ENAVFASILD
LIINCAAFIY IGAWIPFDKF TAADLGIAPW RLIVLAIALI IARRIPALLL LQRFVPDLRN
WREALFSGHF GPMGVGAVYI STLALTKLPK ASDPPASQAE QLSATIQPIV AFIVLCSIIV
HGLSIPFFNL GRHVRTMSHT SPWTSRSNTI EGPEWLHATR RFNRDVDIEV QGAIGTPNDT
QSVSSTTPTP VNGKSAEEIG AVQNGVPSGE NVEMNAAEGQ GPKVKFAE
//
