ID A0A164NKL0_9CRUS Unreviewed; 399 AA.
AC A0A164NKL0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Suppressor of cytokine signaling 6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=APZ42_030527 {ECO:0000313|EMBL:KZS06037.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:KZS06037.1, ECO:0000313|Proteomes:UP000076858};
RN [1] {ECO:0000313|EMBL:KZS06037.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS06037.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS06037.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZS06037.1}.
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DR EMBL; LRGB01002849; KZS06037.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A164NKL0; -.
DR STRING; 35525.A0A164NKL0; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd10387; SH2_SOCS6; 1.
DR CDD; cd03717; SOCS_SOCS_like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035865; SOCS6_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 248..355
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 350..394
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 399 AA; 45215 MW; BC827B3D5181B595 CRC64;
MKKLNWSGLD FLRRDRGAIA RESSSNTSTQ LVTNRWSSES KLHMTDTVSQ SSGDLNQEKP
LSNKGRLSFS DLLRLKRNPT AQGYSEPKTK SSLLDTLKRK FKIARREHSR IRQMNKRHSF
SLSISSIAEE SSERDSLQKS KTLPTVQQNC RLCALPNSVR SARDNYCAIH NLDPLSENQD
DNNDNSLSVA VQEARPPPVN GSESLYPIST AETEMSSHSP SSAVALTTAA SNNSNLAWEL
FKLVKYGWYW GRMTRGEAER KLIDQPDGAF LVRDSSDDCH LLSLSFRSYG RTLHTRIEHT
NGYFSFYAYP EAEQHSSVGQ LIEHLMDTSR SGIFCYSRSR SPGSPSYPVR LTKPVSRFSE
VLPLQYMCRF VIRQYVRMDH IEALPLPESL KSFIVRGNS
//
