ID A0A164YW66_9CRUS Unreviewed; 4780 AA.
AC A0A164YW66;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Pickpocket 9 {ECO:0000313|EMBL:KZS15671.1};
GN ORFNames=APZ42_018879 {ECO:0000313|EMBL:KZS15671.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:KZS15671.1, ECO:0000313|Proteomes:UP000076858};
RN [1] {ECO:0000313|EMBL:KZS15671.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS15671.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS15671.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZS15671.1}.
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DR EMBL; LRGB01000868; KZS15671.1; -; Genomic_DNA.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF141; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF00858; ASC; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 4678..4705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2541..2584
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 777..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1737..1764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2352..2374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3488..3507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2352..2371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4780 AA; 535664 MW; AC708B58ECBB568A CRC64;
MLERLVAWFC NNYLGRYLEN LNTDQLSVAL LQGIMLESYE KLSDHFISAL IVIGEVELEN
VPLKRDILDQ LGLPLQIHAG FVGKISFQIP LRKIRSEPWV ISFEQLYLVA GPKDKNEPYN
EESEENGALE RKMAALDLME AEWRSENDPQ GLSSSSLYSL TYSSWLSYGA SLVTNIVQNI
QLRIKDIHIR YEDGISCPGK VFACGVRVDS LTAQTCDESW VPKFMPATSQ GLMYKLLELD
GLAVYWDTNT ELFANLPLDV LSSKLMQPCS IERNEFLLAP VSGYAHLKRN CNVKPLRSLN
QPRVACDFQL DRVNIEIRDV QYHQLVQCCR SLELLARGLQ FRRWRVDSEV QSHPHPRRQW
RFSVNCIIAE IRKKNQSRNW PFVIRRAKEI VLYVQSFKEH LLNPIGMTAE SKLQRERIES
ELELQELQVL RSIAMQQIAK SQSKNESVLN DAATGNSSLF QRWFSSWWSA EESTNGNEQS
ANEDRVEHEI LETLEDAMRD NTVRQRDILP LQFSSTLKQG LIRLSTCHRT ETGQSWSTLL
EIEFDNVLQE WESRPRLKSN KFHLSLGNVW VRDCSTAASL FPLIVSPQRK DARPFKSFAG
MGSLLPGFNL PFFRSSPSSP NLNVSQDEAP LFDFVYERHP PGSNWDHRLK ITSLAIECVY
NHSLFQKIIE LYSVPHNTTE ERSVLGQRLR QAALSGFEAV KQKTKESLTQ SLTPSSVNLP
SKQQSWDLLI NISAPHILIP ESVVSRDSLL MIIDFGHFHV TRSIVNCIAA ELETTTRNGN
EDDDDEQYIT PCSTPPNESA VTTPLDDAHD MNSFMSGNKE CNDLSDKYNV HFSDLQLLVC
RVKDNWKQAH LKGTSALHLL DRFSILIHVE KYGRLVPGLE KPFLTLTASL PHLVAHINEP
KIHALLSVSK QFRSNVVPTP VYETASEDGD TDETDASLAE TEKSEEHWFM AQFNIEQLSV
EVQSRGRSVA ELQVGGVQAS YSMRPTDSSV HLAVHSLLLV DAMQTLGSDY ELLIASHKHV
SMDSMSGSLK ESEPTSPVSP SSPDPSSHKG QRATSPVSLA QALTSLQTDP SWRKDGLSPP
MARHRMATSA LKSEALILID IVTVEPTWVD GKAEGRIRII KVHFNSLDVI ANQDTVVELA
SFFQRVMPKK TMPSNPDESN FSTGLPSNHS RFPPFALVPD GSTDITFDFH RLTILLLRSV
VKEEMLIGRK VATLTVTEAH ISGNLASDVL VQGSLGGLQV LDLTPEGQKH QRVVSVGHDP
LVEQHQNLYM LVSQGLYDTT KDKNEVKAFS FKFLQPGLEA PGEEEEGYKL SLEIRMASLC
YSHSVHFLAE VAACVSEFKQ SVSNMAMSLK LTAAEMAVDL LHRGTEGLAQ SIYISGSTSV
TEGLSLNAMK EANDEEQPSP PSRVRLSALL ESPILVLPKS AKSPQVLVAH LGQIEISNDI
KVETEHPSQL SEELSGGTHK EHFEVEVRDM SLYSLNVDEK WKSSFSHFYT GPSAFLRITA
QELYSCASPH GRPILHDTLL KFSLHRIVDR PILSDADPFL FPLTDFYPKL EVCDVFQVHG
CVVSPLQVSL SKDQYQQIIQ SLDNLNWNKV DASSNFEAGP DPSTKNRAPA RVKQRELILN
LKFQLPRFSM QLLDNSNRAI VSLSFEDFLV AYEQNCTFSA TVQTSLKSLI LEDLMVKEDS
KYRRLVASND RQSDRIAGRP NLSSFMSSSC PDLRAQGLYN PGSRSLPARL ESDKSQWKSS
VRAKAPQKKP IAKCPSTPPS SSSMMYHQRF TRSGVGDNNL VFIKILLVDP DSPDFALKYN
STHRFIEINF NALDVIINLE SWVMVLDFFG TSTTKVSRQQ KKKVAASSPG YQDWSKMANA
HTVNARWEVE VRSFSLLLNR KDYEVAEATI SNLTWEMASM RGNLDVTGKL GSITVQDLTS
AGKMYRERFI TSGNEALDFQ FFCFSADDPQ LARDYDIRLN LNMASVLYVH TQRFYTECFS
MLEQFQELRR VAGTFGATGQ SGAASVSRKP WRHGTRILLN VEAGSPVILV PICSTSEHLL
VIDLGRISVS NKFVVTDGSV CLPTINKSRK SGLKGLPVVP ITANPETVLV DVIQVELSNM
DLCTGQRQKA NRSQVGDLIL GSYLIRRSGQ SLLKDTCEMK LEVRRNLDSH LKHPVPDMDL
CGLLSTVQCS VDEHQYKLVR GLLAFNLGEP VDFLHSHQPP PTSPIQLPDD SKPPMWAKLK
IHIDLVDVML EVKDSRIGAF STIKFIDSRL VYESNSDGSK DVDLVSQQVV IRDTRYDASS
ATHSATKKNV FTQILEPVTK ARREGSLQAE VHYRSTEDFT RFTVVLNNMR LLAVVDWWTL
FREFLLHSPD EYRGTNNDKG RNSEESDVKP HAKWTATSTR PSPIIVSTGV ISKRAALIDT
RKVPVEFKIN ISDSEVVIIE DTSVRDSSAV ILKGTALLTY RPQIHSKPLS CQLNRVEIFS
SQLNLEEETA LSIVDPATIS IEIVDKSSAT DVKGILDATS SDLHQILEVQ AQQIILRLSY
NDMKLFMRIL DSLPHQARLT SAESTIVNEI NKLKALGFST DDCQTALRSC NDNLEEAALW
LTQNASTVTG QRQPEMAEIQ IRGIEIRTGC VSLCVIDDCR DADLPLAEIT TSQLLLRQSI
DVAQMTGEGT LTCQFAIDYY NRVLSGWEPF VEPFKCHVHW NFLAFNGSIA NRPSQSIFFD
TEDVVNLTCT RALLELFGTV KRNWMEDYYG QNNKELSSLG DGSSVVRQRS PFVPFALHNA
TGSKIKFRTL TASLLTEGAP SAASTKSSRW IHCEAGDVVA FSFENRGKLR HHDSHQTQTH
QLSIELDGWM EFGPVSVDRV GVYFRYASVH SSPSRRNTAA VERDLERVLV VIAVTLEGSA
RRLVTVRSAL QVTNNLEETV ELRLEPPAFN LHPSKTVRVP PCTTYPIPMS YLMSQVNTLI
IFVRPMAEKL PHAFSFCKDP IEWHAPTQTT ANIRQCNPVI SNQDLTYRFA VDIHRENFPP
EKINTNDSEW NAQPAHTITL LSPLVVVNLL PYELLWELKA VGQSGIIKPG KSTSIHTVNV
SAGFQIAFRT ENFVHSSDLV IGTSPHNFST RLRLYDSANR LLLLQVKISS KAPGSVKLSI
SAPYWLVNKA GIPLIFRQEG VQQEAAGQFD EHEMARSLSP MLFSFTDREA SHSLTARIGT
GLHLGCKPHW CQHFPLQKGV RVRSFLVSPR DGRPELVYLV GISIRSGRGR YRDTQIVTLA
PCYQLYNQSS WTLEVSQAYF ATTFTDPGAQ STYLNLVPGC HLPFHWPRLD KDQLLCVRLL
DVKNCHWSGG FAIQNISSFH INIRDGESRA NFLRVEIFQQ ECTFCVVFSD ATGFPPPLRV
DNLALVPIIF HQSDVPEAYL HTTVRPGSSM PYVFDEPTKP ARLNIIAPGG ASSSYDMTTL
KEGSQLTYEN FIYVCLTVTF NGDDMSTGNA LDPNNVELVL DVPEGTRVVL SGKETGKRSQ
LWRMTGSGML QHEGSSPPRD PSNPQIDPSR ILVLDIAGPA LQPSEFVHLM LRKPDPRRQL
TQTWHFTEDG RLCCGHSNVF VQAKDGFYGI RQGNDVVLGP AQSVTYYRLP SGIPAEQAIH
WQRLRPGSGC LSVKTIMDGP TRVLQVADFL NKPSHCHSNE NSVTASTDAE KTSNKQLKVE
MKFKGGLGLS IVNHLPPEEL AYCRLSNISL ELITGNGTLS IDASVQSIQI DDSLQDPHCP
VVVYVSPSVN QDESKDMPAL RLTVHRQLTS RLNADIFKNL IVTFKNLTIN IEENQLFKLL
AFAGFNQSDL ELERIDESEY ESQRSLNAAT SIDAKRYYFG ILKLVLEQVR LSVYTSSKLP
PELKAIKRKL GLTLIKFEDA NIELHPFIRS HPFETAQLII DSVVKHYKDE LKSQAARILG
STDFLGNPLG FVNDVSEGVS GFLYEGNVGG LVQNVTFGLS NSAAKVTGSL SDGLGRVTMD
ERHEEVRQRL LKHTGQSSDH LVAGLKGFGF GILGGMTSIF TQTYEGISNE GLGGLFTGFG
KGLVGTVTKP AVGVLDLATG AASAVRDSSR SSSREIPRRI RPPRLVIGPG GIVPRYSEKQ
GRGQELLFQL NRHEYRETFI AYEALGSLPE SLHMLISSKH IRVFSMNSPN KEVVLDIHLS
ELQSCKSVVI KDFGTQSTAH YYVELSLLLE PDNPLGARRP QVRCDSESLA KRVTQEINYA
KSFPDKVHAQ TINEVGIPKE KVAAISREKI ERAQQKSCQN DQRIFKQFCE NTSIHGLKYL
FEDGSRLIER CAWLLVFLSG ICFSGYFCWQ MWEKWKQSPV LTSVETQLYP LSNIFFPAVT
VCNVNKVSKI KLQDALRNPK YANVSYSEMQ STLRYMTKLD RAINNERPLK ELNQFYKSRN
ISALDLFKIL EETAPSCSDM VMDCNWLGLT KPCMEFFSFL PTDDGMCCTF NSAKYFDPML
GIQSSASEPL RVNGNGYRMG LNLVIDANVD DYSVTTGKFD GFKILVHAPE EFPDVADRGF
VIGPGTETFV AVKGTTSFNT EEVAREVAPD QRQCLVEGEK KLKYFQHYSR SACMVECATR
IMHDNCQCRP YFLRGGNTSR LCEFTSYTCI SNVYEDVRAR GDKICDCLPP CADISELVFF
STIINHTFKL CGQIAFILSD LLTMYLQCRT NVAMFHVYYK EKTGMRYRTD IRFGIEDFIS
AMGGLLGLGL GMSFISVIEL VYFFIVRRFF LQHRIPPDQT LKSSHSPNSD EVRKVWPSSQ
TLSSVMTTME PNVDGQRGLQ LVRRGSLNLP AHMQARLYKY
//
