ID   A0A165C744_9APHY        Unreviewed;       605 AA.
AC   A0A165C744;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE            EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN   ORFNames=LAESUDRAFT_730299 {ECO:0000313|EMBL:KZT02314.1};
OS   Laetiporus sulphureus 93-53.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Laetiporus.
OX   NCBI_TaxID=1314785 {ECO:0000313|EMBL:KZT02314.1, ECO:0000313|Proteomes:UP000076871};
RN   [1] {ECO:0000313|EMBL:KZT02314.1, ECO:0000313|Proteomes:UP000076871}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-53 {ECO:0000313|EMBL:KZT02314.1,
RC   ECO:0000313|Proteomes:UP000076871};
RX   PubMed=26659563; DOI=10.1093/molbev/msv337;
RA   Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA   Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA   Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA   Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT   "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT   Insights into the Origins of Lignocellulose Decay Capabilities.";
RL   Mol. Biol. Evol. 33:959-970(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC         H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC         ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC         Evidence={ECO:0000256|RuleBase:RU362103};
CC   -!- SIMILARITY: Belongs to the lysophospholipase family.
CC       {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR   EMBL; KV427653; KZT02314.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A165C744; -.
DR   STRING; 1314785.A0A165C744; -.
DR   InParanoid; A0A165C744; -.
DR   OrthoDB; 1826981at2759; -.
DR   Proteomes; UP000076871; Unassembled WGS sequence.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR   GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002642; LysoPLipase_cat_dom.
DR   PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR   PANTHER; PTHR10728:SF33; LYSOPHOSPHOLIPASE 1-RELATED; 1.
DR   Pfam; PF01735; PLA2_B; 1.
DR   SMART; SM00022; PLAc; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51210; PLA2C; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW   ECO:0000256|RuleBase:RU362103};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW   ProRule:PRU00555};
KW   Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW   ECO:0000256|RuleBase:RU362103};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076871};
KW   Signal {ECO:0000256|RuleBase:RU362103}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|RuleBase:RU362103"
FT   CHAIN           21..605
FT                   /note="Lysophospholipase"
FT                   /evidence="ECO:0000256|RuleBase:RU362103"
FT                   /id="PRO_5007748304"
FT   DOMAIN          34..605
FT                   /note="PLA2c"
FT                   /evidence="ECO:0000259|PROSITE:PS51210"
SQ   SEQUENCE   605 AA;  63960 MW;  A87420D9299816EF CRC64;
     MFAVLLALSG LCWLPLYASA QSQASKAYAP VVAPCPSGIS VLREAGTTNQ SLSEGESAYV
     SGKRKTVLPA AWKSYLAAVN GSTSDVVSLP SYVSAILNGS FGGSAYPNLS IATSGGGYRA
     ATFGAGVLNA LDARNATSVR AGTGGLLQAS TYLAGLSGGS WMVTSLAQAD FPTLYDLVLG
     PETTTSSGFN GWLANFSLFD PSDSIVQDTV YIIDLADETD GKAGKGFNVS ITDVWARALS
     RHFANGTTAA TFLEKNVTHG AGLTFSSIST LPAFTSHTLP FPIVVTDSIS PYQNDSNILN
     ETEVLVPLTN PIYEINAYEM GSFDPVLGAF ILTKYLGTTN STLCVTEYDQ VSFIEGLSSS
     LFNEAVVLEN AEISDFIEIL SEYLPDGGDI FYGLLPNPFH GLSPNTYIAS NQTVLQLVDG
     GEDGEEIPFT PLLVKAREVD VIVAIDAAAD TSYNWADGSS LIATQDRVSY FPGTYAFPPV
     PTSASTFLSK NLTRYPTFFG CNSSVNSSEP LVIYLANGGP PLGQTPATNT STLQLSYGAE
     ELEAMLSQTF DIATQGRATE SSAGWEKDPE WPACLACAVV DRSRQREGVT RSGVCASCLD
     RYCWS
//