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Database: UniProt
Entry: A0A165D1P4_9APHY
LinkDB: A0A165D1P4_9APHY
Original site: A0A165D1P4_9APHY 
ID   A0A165D1P4_9APHY        Unreviewed;       577 AA.
AC   A0A165D1P4;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=Family S53 protease {ECO:0000313|EMBL:KZT03971.1};
GN   ORFNames=LAESUDRAFT_738083 {ECO:0000313|EMBL:KZT03971.1};
OS   Laetiporus sulphureus 93-53.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Polyporales; Laetiporus.
OX   NCBI_TaxID=1314785 {ECO:0000313|EMBL:KZT03971.1, ECO:0000313|Proteomes:UP000076871};
RN   [1] {ECO:0000313|EMBL:KZT03971.1, ECO:0000313|Proteomes:UP000076871}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-53 {ECO:0000313|EMBL:KZT03971.1,
RC   ECO:0000313|Proteomes:UP000076871};
RX   PubMed=26659563; DOI=10.1093/molbev/msv337;
RA   Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA   Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K.,
RA   Labutti K., Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T.,
RA   Yoshinaga Y., Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT   "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi
RT   Provides Insights into the Origins of Lignocellulose Decay
RT   Capabilities.";
RL   Mol. Biol. Evol. 33:959-970(2016).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; KV427640; KZT03971.1; -; Genomic_DNA.
DR   EnsemblFungi; KZT03971; KZT03971; LAESUDRAFT_738083.
DR   OrthoDB; 1294880at2759; -.
DR   Proteomes; UP000076871; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000076871};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032,
KW   ECO:0000313|EMBL:KZT03971.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076871};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    577       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5007856336.
FT   DOMAIN      223    577       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    299    299       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    303    303       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    494    494       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       535    535       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       536    536       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       556    556       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       558    558       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   577 AA;  60759 MW;  8E1C80D556DD070A CRC64;
     MMYKNTLVAV SLSALALGSA IPVCEESVWD WFEVQLHEFL DNVPNGFSFD GTAESSTNLT
     LRIALAQSNF DGLVEALYNV SDPSSEYYGQ YLSKEEVDSF VQPDSESVEA VTSWLSEYDL
     TATNLSSAGD ILSVELTVGQ ANDLLSADYS LFTHEATGQQ TLRTLNYSIP VDLANHVNFV
     HPTVTFPLFM NNTPIIEVHP ASNQSQVRSA QKRDSACGTG TPWITPACLQ ELYDIPTTAA
     FSLLNQIAVT GYDNEYAQAA DLESFLSEYR TDMSPNTTFS TVTLNGGENP QNKSDAGTEA
     NLDVQYVMGL ATNVSTTFIS TGGDFAQALL DTADYLLGET SPPQVVSTSY GTDESSIGEM
     FALSLCNAYA QLGARGVSVL FASGDGGVSG NKDDGSCTAF VPTFPSGCPF VTSVGATINL
     PTEEGASFSS GGFSNYWPQP SYQASAVSAY LSALGSNDTG LYNVSGRAYP DVAAYGSQFE
     IYTGGALTIV SGTSCSTPTF AAVIALLNDE LINAGKNALG FLNPWLYANS GALNDVATGN
     NLACSDGSTG FYAAAGWDPV TGLGTPNYSS LKSAAGL
//
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