ID   A0A165E0Z9_9APHY        Unreviewed;      1108 AA.
AC   A0A165E0Z9;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=LAESUDRAFT_680055 {ECO:0000313|EMBL:KZT06039.1};
OS   Laetiporus sulphureus 93-53.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Laetiporus.
OX   NCBI_TaxID=1314785 {ECO:0000313|EMBL:KZT06039.1, ECO:0000313|Proteomes:UP000076871};
RN   [1] {ECO:0000313|EMBL:KZT06039.1, ECO:0000313|Proteomes:UP000076871}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-53 {ECO:0000313|EMBL:KZT06039.1,
RC   ECO:0000313|Proteomes:UP000076871};
RX   PubMed=26659563; DOI=10.1093/molbev/msv337;
RA   Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA   Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA   Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA   Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT   "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT   Insights into the Origins of Lignocellulose Decay Capabilities.";
RL   Mol. Biol. Evol. 33:959-970(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
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DR   EMBL; KV427626; KZT06039.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A165E0Z9; -.
DR   STRING; 1314785.A0A165E0Z9; -.
DR   InParanoid; A0A165E0Z9; -.
DR   OrthoDB; 2735303at2759; -.
DR   Proteomes; UP000076871; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF14; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076871};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT   REGION          45..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          557..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1108 AA;  123573 MW;  E68078AB0ADBDEDA CRC64;
     MDIKNINGPG SPCSTTSDSN YFDDIEDIDA FLCMFDDVEL KEQPHSSTEV VNSDFKGKRK
     ASNNLDGKPS KIPRILQEKV SAALEKLAPI VIADLHHSRD IMEDLPYGVQ WEIARLATKG
     FEKQIFTPAA LERLRDLRSN AAAAPQVEDI ARGRTIRATQ DDPYASAYAM ERAAKLPWDE
     LDTEEQVFKQ DPFGGLGCND DKPYLQDKPD WYGGKVHFIA TLHLDGKDQQ LGPRFTFSLD
     PPRLGSSCRF TRRFGSYQFI RVNIPQEIYT KLQNLRCTED ELVDFFTRPI VIHSWVFRAV
     TAKEGTVFLF RTSERWDGRE IVTNGSRSDS VRELSLPQFL SWHNDPSANQ EQTMVKWAAR
     FALGLSNSVP GIRLDPNEVG TEDDIVCPGF SGAGKVPNEM IMTDGCGLVT SNVLISVQKR
     LGWPSEPTAV QMRLGGAKGL LLLDAKSSVP SVVLRPSQIK IHGPVAHDSA PDPALLIIDV
     LKPGRLSTPA RLSTETIINM AENGVPSHVF IQLMQNSVRQ LVRGLTMWTD PSSVYELWRN
     IASAGGVISA RLARESPGSS RAKGYRNLDK SSPEITDNDA DDFDEASQDH STPWWGDPVS
     GCPSSLEETT LVLLDAGFTP DKCRILAEKL REVTKKAVDA YVNKFHISVP MSCTAFVVPD
     PCGVLEPGQV HIKSSYRNLT DRSGRPTEIV LGEVLLTRHP CKVPTDVQKA VAVMHPQLFS
     YVDVIVVSTK GHLFNNETLH CHLASMTGGG DYDGDLMEAF WDPSLVSAFS NAPPAFAQEP
     EAIQKCIVKN TETVDQFLAR TSASGPASVL YELQKHLLAP LKGISRVGIY STMWEASIYK
     YGYKHPHTLF LAYMFTTVLD GVKTGISVSN GVFEEHQKVY SCASLPWKDS IVTRAIFANS
     GHAKRNMGLP PFVMDELHAA VHREYEKQKE YIFTLFPRKG FGPSPEFDHD LARPWNDARE
     LARQAKEGKA DGWQRKQKEL DAIKAHVEAP AASQKGKAKE TEVTFTGLPI DKRQDILRDF
     SIRFDQGPTS TADGQPIFDF DKETIRRLRA SYAYIYDYNR SSDHWSQFPF NVAMRTLCEI
     KAKAHGPSKT VTEDFYIRMK VGRAYARK
//