ID A0A165E9G5_9APHY Unreviewed; 2732 AA.
AC A0A165E9G5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=LAESUDRAFT_725981 {ECO:0000313|EMBL:KZT06527.1};
OS Laetiporus sulphureus 93-53.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Laetiporus.
OX NCBI_TaxID=1314785 {ECO:0000313|EMBL:KZT06527.1, ECO:0000313|Proteomes:UP000076871};
RN [1] {ECO:0000313|EMBL:KZT06527.1, ECO:0000313|Proteomes:UP000076871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-53 {ECO:0000313|EMBL:KZT06527.1,
RC ECO:0000313|Proteomes:UP000076871};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
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DR EMBL; KV427624; KZT06527.1; -; Genomic_DNA.
DR STRING; 1314785.A0A165E9G5; -.
DR InParanoid; A0A165E9G5; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000076871; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000076871}.
FT DOMAIN 1340..1532
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2732 AA; 303529 MW; B51BFEAF489D9EC9 CRC64;
MPVRRGSSAA HNVSGSSSRV HRSNGSNHSV SGPSSLAPSS SLTYVNSTAP ATPQQKVVSV
LVNRLKNKLP CNSGIPLVEV EADDAIQQVV ESLVELSQDA LDIIGWALTE LLEKLAKQTD
MHGYRSIDVL QSQLFVLKVL AICMASRWGR RQDGARPSSR NSKQMSTTSS NPSIHESSST
SSHATRRQHG PSEQLSLLVE PPPLDDNCAK YILSVMVLLL RETAPPKYRL MSSANMDFAA
SHHDFESVEA SDMGSSVDLL SAPALPASIS PVPRMMSRTR HASSTSLNST TPSTVSFGQA
SKHSLMYERT SIVTSKSISA LNTLVAKFAG RVVYHLSASN WNVVLSRVRQ KIHFLASTTE
SDPEIVDLQL MVHSAVDRGR LVQALQELSS LLLNMKHDAQ AAIAIPLRAA IWNWIDMCPE
EYNDTIRYHR RMEGAPERVF DILFDFCESQ HRVNVWPTLA ALACISSERI RTEYQANSLG
MPRGQHGRRD RYFYEMVMRS LTSQKVSEEA VVCALDLCRA AFRIRPEDGA ELAIHLIAHD
IAHDLRSMLA SWNGPKPFYE HPEEIDVALI ADILVTMFRY LPAEDVIHVF TVCLEPQRSD
AVKISVIKAC ITLVNEAVRC PWQAPLDELR DAVKHRLFAI YESTTTRRSE IDKHGNVKTR
SLRPKAKRYT SETLPDRELL TYSLLALHRA VPEWVFSCLT ENHGPEDDPN VIEAWRTPMD
PAIKIAMART SRSLYDAVSR ISPDDPAFTA TISWMKRSAP STLATMCTNL IDSRTDLQAQ
RMWINMAYEV LYRFVRQTNV EHVRECQLTP LRLPAFAVAE IAFLVSLTSA DANVTLTAAH
CLRLLAQAET APNAPVSNGF NEDERVKRYP IYEQLGDPKV LLVGRIGHQR RVRKLMRLMP
SSSPVHLGVW QECYFRWCTL HEIAINKSIE STANGFDSGT APIGDRALSA EEGLYQWQNL
TLFLAAFGSA CLRDQLHPDD LSLNIASEYL ADQMRNLRDP TPLLSHFIQT LLNLLLHEDI
HVRDTARDAL GSEASPRLYT RIFKELDNVV RLTAEGDSVD WDSLAIFVDQ FLAILKVLVE
NVQCLEEIRG MDLCSTLSLV AGFIGRFHDS VAYRLRIKFC SMCEAVFDQA ETITMRKDNG
SRQKIADIII EWIQDPALCD RNFLAAQRDL NLSAFRASVK LFDRLQLQPP EGTSGEEAAH
VVSRLFIRYS TVLFKAWESA RSETFVPDDR STDKSSSFSG VRIGPRDSHM RELVITGLAS
LVSANPEVGV KHTMPLAYET DITKRIIFSY IFARVLPQGI TLVSQDHKPT VHRQSRLCEL
VKGPDLSLAL AICEVCPPAE VDNLIPVMLN LFDTRTSLMA LLKSMIDLEV ARTDSDTSLF
RGNSTCTRFL SAFANIYGYN YLRSLIIPLV KTMTSMPAGH GYDLDPSKVG EQAAKQNQAN
IQLVTSSFLE IIISSSNAVP MMLREICAHI AKVVNEQWPE AKFAAVGAFM FLRFISPAIV
APETVDVEIL RDDFVIRRGL MLVAKIIQNL ANNILFGKEA HMIVLNDFLL ANIMNVTRFL
SDLNRVNPSG SEEEPEEWLD TSYDDTDTIM LQRFFEKYAD KVGKELLSLS KPPAEKGAAQ
TETSSVHGKR IWDALCAALV ELGQPLEGPR MVTISSRMHA EYLDLMSRYE HRDTSPVREL
FSEVITTTPQ NPVMFVLSAS KIDVEVLDIE LLLFYIFKTL TSPSFESRDF DLIVDFTCFT
LGSQIPIQWL KFAYEVIPVD IRARFRTAHI LTPNALALKY IKRLCSLSSG AHLSANYLTY
SSMEELLQRL PEGTFLPSLT YARSLEAEPC TRFEEVTMRH THPMRVPVML EVAQSHLRIT
TVKAQLIGGS TSCKTTEIIP LTDINDVYSV SAGHDTHEFI IRKIRHGVTL YFSSSIRETI
VKAIRGVKGN MRTVQFPGAE RLSRFSNVAA TLLHVGMLGV SSGEEELRIA ANELLQAVCT
YLDFEGKPLV TSKTSLVHGI QGPLLVQLSE ALAAFAPHLA LDFITEVSTN MSREPVHLRV
VCIHYMAPWV KHLVCFTDPA NKLYEPSTTK FRDCVRTLVD LTMADDELHY LIQKHVWTEV
GKLDSSVVNA VLDELMRAAV DGGADSARCD RVADTVGAIS SINVRGRILS RLRKTIGKSS
ANPTRSLADN PHWNEICCLI RLALVAGHHC RNIVHSQLFV PEIVHLVVLT AATGRTRIRI
TVYGVVINLL NSQYTARLAD DTASPEIQAL LSECEQSETL RLFGLRRPTP TSDYVNQDPS
NDKQYIDTME SMVRFLSRVL ETIAGTKGLL NVWRARWMSL ITSSAFQLSP AVQTRAFVAL
GILATSDVDD DLLYQMLVAF KTALAKSSEN DTTSVVSMLR CIRNVVPALP RNSRYLCQLF
WLAVALLQSG HMLLYEEAIH LLRVALEVMN SQGAFSDSGV SATLLDGRVP LEEVACQLDR
LLGLSFESSF SFSLASIIFK GLRHAGLRES AETALRSLVT VTAGSCSSDH HADDGPGTPV
CPDVLGYFVA LLPTVTTTKK FKRLLKECDV DESWLKQDFL SSSSDEEPLA RVPFALLGLS
DGNTALFVTS LIGAMLTSAQ GDDAESQILY NILSDVANAF PDIVSLTYES LQDKIKEAFA
NSSSPGILSA VSNLFRVAVH DSDNRASATG GSTSSLSIDD AATHGPGRSH LFALEEQSMQ
GLANSFQFLP ANQGHATKMI NWISELVMKI IE
//
