ID A0A165EL08_9BASI Unreviewed; 612 AA.
AC A0A165EL08;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 13-SEP-2023, entry version 33.
DE SubName: Full=MTHFR-domain-containing protein {ECO:0000313|EMBL:KZT55084.1};
GN ORFNames=CALCODRAFT_499019 {ECO:0000313|EMBL:KZT55084.1};
OS Calocera cornea HHB12733.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Dacrymycetes;
OC Dacrymycetales; Dacrymycetaceae; Calocera.
OX NCBI_TaxID=1353952 {ECO:0000313|EMBL:KZT55084.1, ECO:0000313|Proteomes:UP000076842};
RN [1] {ECO:0000313|EMBL:KZT55084.1, ECO:0000313|Proteomes:UP000076842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB12733 {ECO:0000313|EMBL:KZT55084.1,
RC ECO:0000313|Proteomes:UP000076842};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; KV424001; KZT55084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A165EL08; -.
DR STRING; 1353952.A0A165EL08; -.
DR InParanoid; A0A165EL08; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000076842; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000076842}.
FT REGION 331..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 67883 MW; 98753CDB578A3168 CRC64;
MKLTEAISRH VASTSTPYYT LEFFPPRTDS GFENLLARLS RLSVVNPVGL SITWGAGGST
KQRSLDLAEA TQRENPVTIL HLTCTNMERA MLDDALDSAK ARGIRNILAL RGDPPRGEEY
WIPCDPQFQH ASDLVKYIRN RHGDEFCIGV AAYPDGHSFD EDTELANLKT KVEAGAEFII
TQLFYDADGF LIWLRKVREI GIEVPVLAGV MPIQSYASFL RMTKLCASRV PPSLIASLEP
IRHDDEAVKD FGVDFATDMI RTITSTKHNG PIVQGVHFCT LNLEKSTWRI LDKLGWIGTS
THVLEEGKNR LIQPDSNAPL SSSSLLITPQ DAASAVAPKD SENSGTIANT TTTLPALPAN
QAATWDDFPN GRFGSADSAA FGVRDPYKNE LGLTTAEVHR LWGQPETIDD LTALFLKHLR
GHSPFSTTPW SPNPIAAETK LILPHLIELT LRGNWSVASQ PAVDCARSDD EVFGWGPKDG
FVFQKAFCEF FCESATLDRL REKATIVDTV KFFAGNAKGE MVTNMALGES NAVTWGVFPG
KEVMQPTVIE RAAFQAWAEE AFGIWSEWAL FFPPASPTRQ LLERVRDERW LVSICHHDFK
NPDSLWDFLL ET
//
