ID A0A165FTI8_9BASI Unreviewed; 2866 AA.
AC A0A165FTI8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=CALCODRAFT_470049 {ECO:0000313|EMBL:KZT57183.1};
OS Calocera cornea HHB12733.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Dacrymycetes;
OC Dacrymycetales; Dacrymycetaceae; Calocera.
OX NCBI_TaxID=1353952 {ECO:0000313|EMBL:KZT57183.1, ECO:0000313|Proteomes:UP000076842};
RN [1] {ECO:0000313|EMBL:KZT57183.1, ECO:0000313|Proteomes:UP000076842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB12733 {ECO:0000313|EMBL:KZT57183.1,
RC ECO:0000313|Proteomes:UP000076842};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
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DR EMBL; KV423967; KZT57183.1; -; Genomic_DNA.
DR STRING; 1353952.A0A165FTI8; -.
DR InParanoid; A0A165FTI8; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000076842; Unassembled WGS sequence.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000076842}.
FT DOMAIN 1488..1689
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2809..2828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2866 AA; 318102 MW; 1CBEF4A6287FC805 CRC64;
MSSSNRPEAH RSGLSHSLSI SRGGIPFMRR RPPHQQHTAH RESVQHIATP PDDTATMTTT
TDTRSNESSW LRPAISYSSL RSGTPHDRHL NSLIMRLKAE LPVYSKRTLS MVEGDEALGQ
TVASIVQLAD FRLDGVAWAL ANLLDELNAG TSPPIGSTSS DSDSRYPPLE VMQSQLFVLK
VLAAAIAYKW QHHTAEGPRT TRGSTWSTRE DRMRQASSST ASSQADLHST RMVYSPPPRL
RSLDEDGDRS RQPSSSSGSS LAGVTQSTAV PSHGAYPWST SALQSPVVSI RDSPMSGPQQ
SFSHTSDVPL MTEQVAKYVL LTLLPYLRKS SAGSYSAAAN TDSYVKASAT TPIDYDRPTN
IAHLITVAAA PVRLRPMPST PSAASVGSVP STPATSTPGY SPSVNSQQAS SQYPARPASG
SGGTNIPLPQ LTPIPSLTIP VSILLSPIPP AWAMIQKGCR LVIYGYISQI IFHLSATNWS
TVYERIQSKI RDVGGEGRDK EGVDMTEIEL VSLSALNRGR LIQVLSDLAS LLIQMRRPAQ
LIMCVAIHAA IMKWINTCPA ELASLIRGEF RLDGAPERVF DTILMIEHEH PKIFVPALSM
LLAISPDRLR SLTVAQYNKP GMKKACNILE TLRKHLNTAT HQSEVSVACY VDLCAAAIHL
PPGDDFSVLG ELASELADDL RLRLITPSPP LKPFWNSSDT IDTHLYADAI VAMFWFAPAY
TVQTVFPKLF APEQAYAVKL VGVKALIRLA AEQLRLPHQP PLSQVFPLAS QHLPDLYHAL
ANPPGAEDDT NVFVHYHPQM KQSDLDNLDD RDTLLLAIVG LWRSDLSFLG SRDDPERLVK
TGARVTRDSQ MLLRTTSQQV LRIVVTQLLV EIGIHINLNM GPGFNAFHDQ DNANISSILC
LISDRLLASR GDYDDQRLYL STLQTCLTHL SRNVDTPAVS PAIFVALNLV EVALLSTLVT
PMMDICAVAC SCLSLLADCE DLTRSRSDAT LYLNHADIVS RVTAYKQLSD PSDRAIGGHA
YQQRRIRTIL KQIAFAWPVN IATWQEYHRK LSSFDAAAIR SADSAATAPR MRQASRWDSS
GDEQFEWQNT VLFLATFSGC CLGTGDMQSL ADFVPRSDLP EQFLETKAPE LLLSSFLAST
CEILLRGAPF ASNTVRDALG SDLDPRCFPQ LLGHLERLCI ANFERPSATG GDWDDDTLFM
MLQVSTVLTR ILANPDAVQL SASRVDFGRI IRLFHDFINT YEGDFEETLR AKLQFASLSE
AAFSCEDLPL GNDFHLRQTC LNTFSEWVTD IQPGRATGIV SATLTKDVEN TLLRAIIILT
DGLSLKSDDE GSKVQEQSRM FYHYFRFFLG IVTRTLASTD IPRTVSTLDV SQPVDLLGLV
AATDMKTIAL ERDMKILREK AFSGLANLLF ANHQAGFKHC FSMTFHEDAR IRAAFLQIFK
EALDRGTAFH MSEDLPPTIK SNVLIEFVRD PNLLVVQALC EVAVPNDAVE DLESVLLHIF
DQEESLVALA KVLIEQEFQR TSQEAELFRN NSLRNRLLSR IAREQSSSYL RRVLSPLMKR
IVELPSDLTL EIDPHKIDPH QTDDDETRTK TRTENAKAIA KITTVFLATL EAASSRVPNV
IREICHHIAV IAGKVFPNNV YASVAGFMFL RCINPAISQP STVGIEIDVT PRNQRVLLLV
TKVIQNVANN VLFGKEGAHM EVLNEHMLEA IPYVWKFLRD VSSDPRHRPV NWSEMPVRHA
DETDILILHR FFHRNLGNIG QQLLTIHTKA STPQQQQLYL TEGKRLWDQL VDKLVEVGSL
PENLAPISTR WEAHAPLQGF LRRYVRANLE NVAHLFVRLQ PDTPTLLYQA SKIQADVIEY
DALINLIFRE LSREPTEDFQ IIVDMTSFTN TSIIPSRWIK HFVDLIPLEL VERCRAIYFV
NINRVGQSYL RKLYYEFSGL GLDRLNMSSI SIADLRKMFP ASEVLYDMEA DRGSAIEFTD
VDLWDVFHTR HSCSLRVSAT QLYVETIKPQ TIFPGFQARL VEIVPLAEID DCVQSQTVQD
EMLFAVARAK GEALRFSSRD GEAIMRAIRK AKEGVPGYKA KDSSREHRFN AGTALLNVAL
NNLCHKDDSV RIAALGLLRS TVGRMGYNLA VLPTGYFVPA NPYTTALSYA DVVVKGLPHI
VVDFLKDFSS SFGRLTNVEK IACLKYLRPF IKSLALETAN QWTFLGRDAM SMQMRECIRH
FIALTVNFES VYGALQGSIW SVIARHPGLA RLAVDEVVKA AVDGLTGTRK TDILADTLVL
LSSTYARGKT IARLQKLLTR VTFRSSAPFT DNALWNEVAI LTRLVLVLTS ETENPMHVIG
YFAELSHFIT LLAGTGPDKM RISVHGITLN LLQALSNLRQ ELRSDFSSIQ GMIELLRSND
FLRDFGLVQT KFAGLENTEF IVGTGQLPVD AMRRITGFLL DAAEAGSETP SQANAWRARW
TSLLVATALR SPPYVQTRSY YILGTVLTSV PLSGPYIDDD LVQQFLHALD VIITKPVTEG
KNNCLASILD CLCRILFALP DESKYPTNLF WLAVMLFQSN IKALYRPLVE LMRGILDVLQ
RRHYLEHVAF SDYLLDARLS LTYDWTGLEA NIGLQFQTYF SICLAHCITY ALRNPDTQDA
ASTLLYSLLM ATRSKERDLE PGSLLSHDSI GYFLALVTVS TTPSAMLQLL RTARVGEDWY
PDSLMDPAAD PNATPILSFG MLGIQDHDKA LVTAAFLLSL LRGARSDAER ELLCHMLADI
SQEFPKVVEQ IFDQLEKTTD VFSTSNNRSI LEALGTIYSV VLTRQSNRSS TSIGRANSDG
DGQSRAGTTN STTLQQALED YGMTGLIGSP PLDILEACAL ITRTFT
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