ID A0A165GKV9_XYLHT Unreviewed; 1103 AA.
AC A0A165GKV9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=L228DRAFT_268791 {ECO:0000313|EMBL:KZF22316.1};
OS Xylona heveae (strain CBS 132557 / TC161).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Xylonomycetes;
OC Xylonales; Xylonaceae; Xylona.
OX NCBI_TaxID=1328760 {ECO:0000313|EMBL:KZF22316.1, ECO:0000313|Proteomes:UP000076632};
RN [1] {ECO:0000313|EMBL:KZF22316.1, ECO:0000313|Proteomes:UP000076632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TC161 {ECO:0000313|EMBL:KZF22316.1,
RC ECO:0000313|Proteomes:UP000076632};
RX PubMed=26693682; DOI=10.1016/j.funbio.2015.10.002;
RA Gazis R., Kuo A., Riley R., LaButti K., Lipzen A., Lin J., Amirebrahimi M.,
RA Hesse C.N., Spatafora J.W., Henrissat B., Hainaut M., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The genome of Xylona heveae provides a window into fungal endophytism.";
RL Fungal Biol. 120:26-42(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
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DR EMBL; KV407459; KZF22316.1; -; Genomic_DNA.
DR RefSeq; XP_018187871.1; XM_018335196.1.
DR AlphaFoldDB; A0A165GKV9; -.
DR STRING; 1328760.A0A165GKV9; -.
DR GeneID; 28900333; -.
DR InParanoid; A0A165GKV9; -.
DR OMA; EFQFRPM; -.
DR OrthoDB; 1422944at2759; -.
DR Proteomes; UP000076632; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000076632};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 192..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..348
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 902..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..972
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 120340 MW; 2D90569DEAF800EC CRC64;
MGALEPHVLQ EALALQDALI ADPANLDAED EEDGLSPLLH AKPRANSNAS IRSRGQSLAS
RRSNDFDSRD WFFHSPLLYW NCSSAEIAAD PDILRTINSR ANFTSANDFT LRHSTVFAGK
SFKGDRLVAA DALVISLLSK IKSSVTEDWI GRAQRLVNAA PGRWSLYSSD PLVARPWLYE
FRFQPMSLHD DFLLALAYLF MAAYVGVSLS KMRAVKSRFG LVVTVIVQIA TSIMASFTIC
TMCRINLTGI PHEAYPFVVL AIGLENMFRV INAVLAIPGE MPTTTRLATA LGDIGHLSLA
SAGQNLLILG ILSKVVSPGV AAFCAFAAVA LVFDFIFHLT FFVAVLSVDV RRMELQESLE
RVNVEKTDAA KSDAKRQTWN EALYKGELPF STRIAGSAIL IAFVVALNGH FFENETPVQV
TTRLYRLLKS SGTERTDPTP ASLEPVNQAR TPTAWMRLQD HDTAKELIDI VKPHAHRIIA
RVHDPLVFVL SGADRKGGHT VTPRFSELFH RLLEEHLLSF VLALIITLAA VSLLMNYLLW
NEIQDGPSDT EERLLRVKTL PAAHDLDVAQ VVASSRGVLV SIALDRSVCV WSPKSGSDVF
ENRILRADAV GRPLWPVSAC AIDDAAQLVA ICSASGHIYV WSVAEHHFTK SLTIDLAEQQ
PCAFFFARIR TGDSLGLRLI LIRPDGCMIE SDMETDEVDQ LQICRNPLVC ARVIDNPKAQ
INIITVSRSG CMHIVSRDFN HWVSEGLELS KPRQLPSGKI IKVKSVVPVP ALGMVLAVKL
CEIDVIDLHY RTVIRSLQTG QVKGQSLRVI HSPRRPCLAC GASSIGSFSI VYTEAETHDC
MMHTFTSGRP GVPLCLTSRS TGRGPSCCGI EYAEESLHWV ENSSAWEATG VNNVVGIRQV
PEIDDSGSSS SSDSGSSSCD LSDCTGIGAG ILRKRKTTMT KTSGSSTPTH LSSSTSHHRH
PHHPHSSPST PRPQRRRRSS PFGGTTASTA SSSSSDESGW EAWMLSASGE VRTSPLILDN
DVPGATASLS SSNRPFYSSL HLLVSKAGPI TQLGKRSVVV GFGNVLKLLM VGNERFTEAN
DPYDDIAFAS VGYRRRLVGR KAL
//