ID A0A165I9F4_9BASI Unreviewed; 1565 AA.
AC A0A165I9F4;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:KZT60289.1};
GN ORFNames=CALCODRAFT_127867 {ECO:0000313|EMBL:KZT60289.1};
OS Calocera cornea HHB12733.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Dacrymycetes;
OC Dacrymycetales; Dacrymycetaceae; Calocera.
OX NCBI_TaxID=1353952 {ECO:0000313|EMBL:KZT60289.1, ECO:0000313|Proteomes:UP000076842};
RN [1] {ECO:0000313|EMBL:KZT60289.1, ECO:0000313|Proteomes:UP000076842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB12733 {ECO:0000313|EMBL:KZT60289.1,
RC ECO:0000313|Proteomes:UP000076842};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
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DR EMBL; KV423932; KZT60289.1; -; Genomic_DNA.
DR STRING; 1353952.A0A165I9F4; -.
DR InParanoid; A0A165I9F4; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000076842; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000076842};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 50..111
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1072..1208
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1289..1528
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..899
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1565 AA; 165295 MW; 0CFF19A459F64E5E CRC64;
MTTTAAYHTA PLGRAGATTS ASATTTTSTT PTSSIPLRPR RPGAPSPQPQ PEEYVIALHS
YTPPQGMTTC IAFHAGDVIL VHSKDPGGWW DGSLAGQRGW FPSNYVSGDL GAAGAAGAGS
SKPDTPTSSS STPSSSSTTP RTPTQPSPTR APRSPHTHAR PRIPHAFTDA PHPHPPPRSH
PAASASASAS ASPHGSPTKS TSATRVSPGT LSPPLSAAAF FSPNHGHAHS PQSSISTAAT
STLSHARSGT SVTSATSASS GHSRALLTAQ HTRSNTSLPP TTAATAALSP GSKPGTLDAV
HKSVLLLSRA AHARRRSHYG GAAACVVSSV RTVLTAAECL SRSSGQLERW PELREARKDV
LGCLGGIVKR AKALGGQPER AEGAGREKEG HELQEGGAGK GPEKGQEGAH EERKAEVEME
TGMGMELDSE AETRELEHML LLAEEVLVRI RHLVDVALRC GIDVPGATLS SDGAGGLPGA
SGGSSVGTAG GVLASPQLDE LESMRTPTPA SAPLNANANA NAQPALPRVV ETDAEGDRAQ
HRPPPKPRVQ AAIAAHRARS LADLRAKHAR EEPPPPPTPV AGGVLGKSQG RPAEEAGRNG
NGTGTGTGRE RGGSESSTSA GHSGSSQSGS MASLSSVASA ASDRDAGAAL GSSVNGGPIV
RTPGELTQLL KHTQDASVSL FAALIGHVQT HSSGGHAASH ARLVEVAAGA VGKLREAMWV
VDAVVNHLAG KGRDKGVERL INARRGLWRL AGEVVDAAAG LTRGPAPGLA GEPASAEEEK
KERLTKRGFE ALRAVGDCVV AVKMGLAGIG PAESIKLDEL ASVEAFIRGG VVSALPGGNS
GPTASLGPGG RPGTASGRGK ETLDALAIKA ARLLSLREEY LEEEEEEEEE EDDDEEEQDE
HGHTPVPDVN QDTLRPKQLA KDVASTAPSS EVADAQSGTS ESGHSTTSQA TLTHSHSQSQ
SLSFSARPPA PLRILTGFGI APSDGPVSPE SGRLSEDGLN DLNIPLRSPT AFADPSRQQL
QLQLPMPSFT ALMDEKFDIG DLTYKPQTKL SGEASDWLTT DPDDPADVIL NPDETVIGGT
LPALVKRMTS HVATTELSFS ASFFMTFRLF STPLDLVDCL VQRWDVKLPV APGGRAMTKI
EHQVWHDRML IPIRLRILNF VKTWLESHWR AETDGPALAP LQFFVDQAPD GMLKAASRKI
NDLIATRRLR PESIYNKYAA ATISQANAPR GLDRTKSFDR MRSVTPLPGG NGAASYMSAN
PPPAPIVSRS LYSSLRAIPP PPINVTDFDP MELARQLSIM ENKLYMSIQA QELLDLGKSG
APPAVSIKAI TSLSTAITGL ITDSVLREQQ ELKKRANLLK YYIKVAERSF ELKNFSLLFS
ILAALTSSTV LRLSKTWAGV SSKYRTKLDE LRKVTDYTRN YSEYRSRLRE TEPAAVPFLG
VYLTDITFCN GGNPSHRPSP VRSDVQLINF NKYRKLARIV SDMQRFQKAY NLLEISEAQR
FLQSVLQESR TSEDHKDLYR RSLLIEPRET AGEPASADSV RTRTDIFGWA ARSLGQTNPA
NPVVA
//
