ID A0A165JAA8_EXIGL Unreviewed; 1060 AA.
AC A0A165JAA8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=EXIGLDRAFT_708456 {ECO:0000313|EMBL:KZV94561.1};
OS Exidia glandulosa HHB12029.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Auriculariales; Exidiaceae; Exidia.
OX NCBI_TaxID=1314781 {ECO:0000313|EMBL:KZV94561.1, ECO:0000313|Proteomes:UP000077266};
RN [1] {ECO:0000313|EMBL:KZV94561.1, ECO:0000313|Proteomes:UP000077266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB12029 {ECO:0000313|EMBL:KZV94561.1,
RC ECO:0000313|Proteomes:UP000077266};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; KV425970; KZV94561.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A165JAA8; -.
DR STRING; 1314781.A0A165JAA8; -.
DR InParanoid; A0A165JAA8; -.
DR OrthoDB; 45524at2759; -.
DR Proteomes; UP000077266; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000077266};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 172..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 688..794
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 60..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 117410 MW; E73DAF9345E02152 CRC64;
MSLHGGSFAE YDKRLHALAR LRATQAVMRN EVDTTRQVLS ELREIATSYQ AFRRRVKTLQ
ADADDGPRSG AAHPPRRQPS YGDGGVPRPE SLSDIHSRYS RALDIAEDMN SYIPSLLGSL
REIREADTRG AQKAQAFAAD LKWLDTPLPS RCFRAYTRDC PVHGWARVKL MLLALVLVLL
TLASVVAVAF AAVFVVWPFM LRCAGLAMRF WRWLKRVIFV LRTIVGDGDS GAYDGAQRGM
SAQSPVMGTY AIPWYSASSA DTQRRSLWKK STSSDGLTYL EWTEDALCHE DGEEVRERVA
GEGGEEKVAT GLSVTLGGCG EESGRVVDVF YDFHETDEVE AFWPLREALH RRVLVRQQLR
ASEPGIAFRV RLGDGHVLLR EVHAHVFVAV VACGLDELVA NVPDAQGVHA MQHGELARRA
PPLRAQTREM RDLCWVERRR RAQHGQRSGA GVLSTSFGAG GLNGLGASFL NDNPLATSVY
DALDPWSAAP TPPPAARPSP FGFLDGESPT LTDRFGCRAH PPSSEATRVP AVYAKAFALV
DPNSSGETSL SSLHRVVATS GLPAQTIDRI VNLVSTHTRV TRLEFYVALA LVALAQSGED
ISIERVASLA QQNSLPEPQL DLSVIAASAF NNAFRTAPVV TPSAYSAADD PWSAPGVIPS
ENNTAPTSAP VGLPSAIGTG LPKDWFRRQE SVRVDVHGQL GFIFNRYTVY ELQTERGGPV
LRRYSEFVVL WDCLVLRYPF RILPNLPPKR IGTDEAFIEQ RRKGLARFIN FAVNHPVVKD
DGLLAAFLTE PSFEEWRKHS PISLEEESSS KRIDRIEEMT IPSDLDDKLE SVRRKLGAVI
EHWQRICLLG DRLAKRREAA AADLTRLAMT LNSLNEVNGT CWRGESCDAC AGVRDGLGRV
SGRVQGHAHN LERRADTLFA ATLETLKGQR DLYIAMRDLF SRHDRLSGDA VERLKKRVAT
FQDRLEGVRA AQKDGWAAEA DRIAQGIEQD QAAIAAQLAR RVFIRHCMWH ELRVVLHNRE
NTLLVHALQT FGRDEREFAE VALATWSAFK EEVDSMPLDI
//
