ID A0A165NBC2_EXIGL Unreviewed; 440 AA.
AC A0A165NBC2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:KZW00495.1};
GN ORFNames=EXIGLDRAFT_604133 {ECO:0000313|EMBL:KZW00495.1};
OS Exidia glandulosa HHB12029.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Auriculariales; Exidiaceae; Exidia.
OX NCBI_TaxID=1314781 {ECO:0000313|EMBL:KZW00495.1, ECO:0000313|Proteomes:UP000077266};
RN [1] {ECO:0000313|EMBL:KZW00495.1, ECO:0000313|Proteomes:UP000077266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB12029 {ECO:0000313|EMBL:KZW00495.1,
RC ECO:0000313|Proteomes:UP000077266};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
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DR EMBL; KV425900; KZW00495.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A165NBC2; -.
DR STRING; 1314781.A0A165NBC2; -.
DR InParanoid; A0A165NBC2; -.
DR OrthoDB; 1654263at2759; -.
DR Proteomes; UP000077266; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000077266}.
FT DOMAIN 22..155
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 180..416
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 440 AA; 49767 MW; FCD390157D0FE592 CRC64;
MRNLPWYLRP SYLEGRDIQA DVDGNVKAGT LAALLEWLVS DPLVEGQDKA YREVFLKTFT
SFTTPDVVFE SLQRQYNMSP PPNLDETQLQ RWHEKRSQIQ MRVLDVLRGW LEEHHMLQED
SHIALSMQEF LSQIRSPPPA AAAARQILLS MERLVVAPTF PSVSRRRGRQ QPLSNVLNID
ATVLAQQLTV HEAFLFSRIR PQELVRYTKD QKGPGTVHLR AFCGTSDKLA ALVKSTVLEL
DALDKRVDAL EYWIKVAHKC LGVNNISSMS AIVAALSSAD LSHLSRTWTE VTSSSTKLLH
QMQKYNDPNS NYSHCRQYLQ TVEGPCVPFI GHPDKLNSLL SPQSTVRPFP PNAAAPAPAA
APIINFSKRY GIAQAIDAIL RHQRQPYTFA EDPVTMGFLQ ERLAIAAAKD NELFWKRSQE
IRRVEAAFGD IKRQMEWAGF
//
