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Database: UniProt
Entry: A0A165QAC6_9SPHN
LinkDB: A0A165QAC6_9SPHN
Original site: A0A165QAC6_9SPHN 
ID   A0A165QAC6_9SPHN        Unreviewed;       342 AA.
AC   A0A165QAC6;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   08-MAY-2019, entry version 16.
DE   RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase {ECO:0000256|HAMAP-Rule:MF_00113, ECO:0000256|SAAS:SAAS00958187};
DE            EC=2.4.99.17 {ECO:0000256|HAMAP-Rule:MF_00113, ECO:0000256|SAAS:SAAS00958171};
DE   AltName: Full=Queuosine biosynthesis protein QueA {ECO:0000256|HAMAP-Rule:MF_00113};
GN   Name=queA {ECO:0000256|HAMAP-Rule:MF_00113};
GN   ORFNames=A3736_11810 {ECO:0000313|EMBL:KZY55179.1};
OS   Erythrobacter sp. HI0063.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Erythrobacter.
OX   NCBI_TaxID=1822240 {ECO:0000313|EMBL:KZY55179.1, ECO:0000313|Proteomes:UP000077326};
RN   [1] {ECO:0000313|EMBL:KZY55179.1, ECO:0000313|Proteomes:UP000077326}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI0063 {ECO:0000313|EMBL:KZY55179.1,
RC   ECO:0000313|Proteomes:UP000077326};
RA   Sosa O.A.;
RT   "Microbial cycling of marine high molecular weight dissolved organic
RT   matter.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transfers and isomerizes the ribose moiety from AdoMet
CC       to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give
CC       epoxyqueuosine (oQ-tRNA). {ECO:0000256|HAMAP-Rule:MF_00113,
CC       ECO:0000256|SAAS:SAAS00958175}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-
CC         L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-
CC         methionine; Xref=Rhea:RHEA:32155, Rhea:RHEA-COMP:10342,
CC         Rhea:RHEA-COMP:10346, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:82833,
CC         ChEBI:CHEBI:82834; EC=2.4.99.17; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00113, ECO:0000256|SAAS:SAAS01116098};
CC   -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00113, ECO:0000256|SAAS:SAAS00958180}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00113,
CC       ECO:0000256|SAAS:SAAS00958162}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00113,
CC       ECO:0000256|SAAS:SAAS00958183}.
CC   -!- SIMILARITY: Belongs to the QueA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00113, ECO:0000256|SAAS:SAAS00958161}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KZY55179.1}.
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DR   EMBL; LWFF01000318; KZY55179.1; -; Genomic_DNA.
DR   RefSeq; WP_067683440.1; NZ_LWFF01000318.1.
DR   EnsemblBacteria; KZY55179; KZY55179; A3736_11810.
DR   UniPathway; UPA00392; -.
DR   Proteomes; UP000077326; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.10.240; -; 1.
DR   Gene3D; 3.40.1780.10; -; 2.
DR   HAMAP; MF_00113; QueA; 1.
DR   InterPro; IPR003699; QueA.
DR   InterPro; IPR042118; QueA_dom1.
DR   InterPro; IPR042119; QueA_dom2.
DR   InterPro; IPR036100; QueA_sf.
DR   PANTHER; PTHR30307; PTHR30307; 1.
DR   Pfam; PF02547; Queuosine_synth; 1.
DR   SUPFAM; SSF111337; SSF111337; 1.
DR   TIGRFAMs; TIGR00113; queA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000077326};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958179};
KW   Isomerase {ECO:0000313|EMBL:KZY55179.1};
KW   Queuosine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077326};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958172};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958166, ECO:0000313|EMBL:KZY55179.1}.
SQ   SEQUENCE   342 AA;  37691 MW;  142A5F15C869D5B3 CRC64;
     MKVDLFDFEL PPERIALRPV RPRDAARMLV VRPDGPFEDR GVRDLPALLR KGDVLVFNDT
     RVIPAQLEGR RGEAKIGVTL HKRIDLRRWQ AFIRNAKRVK EGNILTFGGG VTAVAESRHE
     DGSWTLAFPG TEPVELLLER AGTMPLPPYI AGKRATDEAD REDYQTMFAA RDGAVAAPTA
     SLHFTPELVS ALDEAGIGRE ILTLHVGAGT FLPVKAEDTA DHRMHSEWGR IEPDVAERLN
     AARASGGRLI AVGTTSLRLL ESAATPEGTI TGWEGDTDIF ITPGYQFRAV DGLMTNFHLP
     KSTLFMLVSA LMGRERMQAA YGHAIESDYR FYSYGDSSLL LP
//
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