ID A0A165RCW1_9AGAM Unreviewed; 1246 AA.
AC A0A165RCW1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 28-JUN-2023, entry version 24.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=NEOLEDRAFT_1136086 {ECO:0000313|EMBL:KZT23633.1};
OS Neolentinus lepideus HHB14362 ss-1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Neolentinus.
OX NCBI_TaxID=1314782 {ECO:0000313|EMBL:KZT23633.1, ECO:0000313|Proteomes:UP000076761};
RN [1] {ECO:0000313|EMBL:KZT23633.1, ECO:0000313|Proteomes:UP000076761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB14362 ss-1 {ECO:0000313|EMBL:KZT23633.1,
RC ECO:0000313|Proteomes:UP000076761};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KV425583; KZT23633.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A165RCW1; -.
DR STRING; 1314782.A0A165RCW1; -.
DR InParanoid; A0A165RCW1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000076761; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000076761}.
FT DOMAIN 1073..1089
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 806..840
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 62..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 138469 MW; 1F80647124833599 CRC64;
MPPQKSVGQM KQKSLMSWFG KPNGEGVANG AVKTPKKEAR IPATPVKGVA PVEKPVSLRT
PEQKQPAPSS QPSATTRSSD GEGWCSSKDT PPTSDLIDVD MLSGDEAKAS KSKSTKRKMV
IDSDEEETFH GAGKGSSIYR SSSPVAMASK SQAKKPRVSL VPSDDEDDDN ATISSFSSRL
TRFRKSPTKR LGSRSDGDDD DFVVPEEEDE SDAPSARVHG RGRSSSTSSR STALSDGDFD
DDGSEEETSK AKKTKSRAKV ARPALKSSNE TGRRSSDAFL TAAEQRMQAQ KNEKKSTEEP
FAFLVNPRDK DGLRPGEPGY DPRTLFIPRS AWKEFSPFEK QFWEIKQNHF DTVLFFQKGK
FFELYEEDAR VGHREFDLKM TQRVKMSMVG VPEMSFNFWA AKFLAKGYKV GRVDQAETAL
GAEMRLSKSK GKAVDDKPKD KIVRRQLNKV YTNGTLVDDQ LLSDDQAGHC ISIREEPVAS
DNSSGSFGIC VLDSSTSEFS LSSFEDDVCR TKLETMMRQL RPKELVYTKG NLSVPTTRLL
KGILPPSCLW TSLRDCEGFS YDATLKELKN MYPPGDDEDA MMEDDALGSG VPEAIRTMIP
SQNAVVALGA MIWYLRQLNI DKDIFSMKNF NVYDPMKRGQ GLILDGQTLA HIEVLMNSEN
TEEGTLLKLF NHCITPFGKR LFRIWLCVPL REVSDINARL DAVQDLLDHP TFENEFTDIA
KGLPDLERIV SRIHARNCKV LDFLKVLNAF DKLNKGLVQM AKASETFKSN TILGLLRSAP
DVKPNIKHAE QMFIRPEKGS DELVPKEGKD EAYDNIMAEI SGLEEELDQE LKKLEKKTGL
SLSYWHSAVG TKDIYLVQTS ANEKDIPKNW TKSGATKAYK RWLVPSLVPT IRKVKEAREN
RSTIVKDFKN RVFAEFDTDR AIWLRAIRVM AELDCLFSLA KASSALGEPV CRPEFIEGDS
AWVQFEQLRH PALCARNNNF IPNDIELGGS VGRIALLTGP NMGGKSTVMR MTAVGVIMAQ
LGMLVPAAKA RICPVDAILT RMGAYDNMFA NASTFKVELD ECSKILRDAT PKSLVILDEL
GRGTSTYDGM AIASAVLHHL ATHILALSFF ATHYGSLTDD FSYHPNIRNM HMETLVDDDK
RELVFLYKLV EGVATSSFGT HVANLAGVPM EVIKRAAVVS DDFAKQFKDK VEGRKKQARL
PLVAQADFVH LYGLALGNLK LDDDPVRKRE VMRLIKGAVG KYITQP
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