ID A0A165SJP3_9AGAM Unreviewed; 279 AA.
AC A0A165SJP3;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 28-JUN-2023, entry version 23.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|ARBA:ARBA00020629, ECO:0000256|RuleBase:RU364141};
DE AltName: Full=Mediator complex subunit 4 {ECO:0000256|ARBA:ARBA00031257, ECO:0000256|RuleBase:RU364141};
GN Name=MED4 {ECO:0000256|RuleBase:RU364141};
GN ORFNames=NEOLEDRAFT_1134089 {ECO:0000313|EMBL:KZT25265.1};
OS Neolentinus lepideus HHB14362 ss-1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Neolentinus.
OX NCBI_TaxID=1314782 {ECO:0000313|EMBL:KZT25265.1, ECO:0000313|Proteomes:UP000076761};
RN [1] {ECO:0000313|EMBL:KZT25265.1, ECO:0000313|Proteomes:UP000076761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB14362 ss-1 {ECO:0000313|EMBL:KZT25265.1,
RC ECO:0000313|Proteomes:UP000076761};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364141}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
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DR EMBL; KV425573; KZT25265.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A165SJP3; -.
DR STRING; 1314782.A0A165SJP3; -.
DR InParanoid; A0A165SJP3; -.
DR OrthoDB; 1662081at2759; -.
DR Proteomes; UP000076761; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019258; Mediator_Med4.
DR PANTHER; PTHR13208; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR PANTHER; PTHR13208:SF2; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR Pfam; PF10018; Med4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364141};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW Reference proteome {ECO:0000313|Proteomes:UP000076761};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364141};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364141}.
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..159
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 257..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 30817 MW; 0F187A796CFE8E9B CRC64;
MSQSTFSQSS TSQFPMSQSQ PLQSQSQGTS RMSSQGTLNS TNPYEPIDSD LSMTSILLEP
LNHLQSLAST LFLSLSPNPK PPPPPPISAF VETDTAIAAA VSLARIHQIK QRKIESLKND
ILELDRRWME ICQEMEVGRR ELERMIDEGE ERIAEIDKAK EAAIPYPELL AYAQSLSAFT
SAPPNMPDLS LPGQPPPPLF FPPFPNEEKM RRGRLNAEAP LGLLGEIHSV GRPPTVSPTK
PADGGAHMPP GANIYRPTEQ RPQQQQQLFD FDLDLNPDL
//
