ID A0A165SM43_9AGAM Unreviewed; 1292 AA.
AC A0A165SM43;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dbl-like domain-containing protein {ECO:0000313|EMBL:KZT25369.1};
GN ORFNames=NEOLEDRAFT_1065480 {ECO:0000313|EMBL:KZT25369.1};
OS Neolentinus lepideus HHB14362 ss-1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Neolentinus.
OX NCBI_TaxID=1314782 {ECO:0000313|EMBL:KZT25369.1, ECO:0000313|Proteomes:UP000076761};
RN [1] {ECO:0000313|EMBL:KZT25369.1, ECO:0000313|Proteomes:UP000076761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB14362 ss-1 {ECO:0000313|EMBL:KZT25369.1,
RC ECO:0000313|Proteomes:UP000076761};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
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DR EMBL; KV425572; KZT25369.1; -; Genomic_DNA.
DR STRING; 1314782.A0A165SM43; -.
DR InParanoid; A0A165SM43; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000076761; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000076761}.
FT DOMAIN 248..432
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 473..664
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 699..840
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 883..1192
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 147765 MW; 03C7CFA46C5BD8C2 CRC64;
MPDLLGESSS HNRSYSTQSA NESGPSNGRT IHTDYPKDIK SRLGLNPEDF EEYDDDDDVY
GYSDSEDAED RFVNFALLSH IAMRLRDKVP RGTHVKGGIP YPRAFTGKDI VSTIQGQIQR
ELLISHGIST NDRRIALQIA RSLQSQLFFY EVEWGGRVLE DGVEDVYMFL DDEEGTSEAR
IEREELPTGV ITMLTKCYSS DCSEDQPCYA YLCPRKVRIV CTTLRWRKEN GWEVPEEVIR
TLPASEISRQ TIIHKVISKE KQYVEDLDLV ESLFIKPLRI ADPPVIHPDR LEDFIEEVFG
NILDLRECNR RLLENLYVRQ REQAPIIQRI GDVFLDAATE FRLAYPIYVG HLPLAEKRMK
DETDNNVEFR MFLELSARNP DSRRIDLKHF LTRPSEHLQK YPVLLEAIHH ETAEGNPDAD
FLMEAIQAIK NLQTVAQLLT FQSAMGKGPT GKFEWHNLVS DEYRNSLPKK ESKRQMIIFE
LIKGEMAYVK DLESFETIYI RPLRAADPPI IPPSRLESFI QDVFHNYRQL LYHHRKLLEN
LHEIQREQHP VLRSITEAIL DAFLNFREAY LEYVPNYPIA AYRIDEEMAN NPLFKAFVDQ
CVRHPDAHKL DIKNFINRPI PRLLRYELLL KNVLEETEPD HEDQEAIPQL LDVIKALGKE
TEPGVASAKQ KVELWRYNAN LVFKPGEHVD MDLLDENRSL IHTGKLLRQP DTGLGLEGWT
ELFVLLFDNY VVMTKPKERD SVTKYHVNRR PIPLDLLTLA SFTDPPTQRG TGLIGFNRGA
KHADQPTPPA LNSADSATDA KLVYPLTIHY NGRMGGLYML YAESAQVRAD WKQKLEEAIG
LRKVVQESNK VFEIDTLSTD TFLVPSILAG PTNPSWNNEN TFTGKVTCSV PFTTADGRAL
VAIGCAEGVW IGFRHDSRSM RRVLHLKQVT QCAMLEDFGI FLVLADRSLF AYHIEALVPS
SPQVVHASQT PQKLSKNSEN VHFFSVGNLN GRTLVVYMKK NRLDNVFRVL EPVVDNINER
NRAPASLGSR FGFRSQRSEW FRVYRDFFLP SETFDLIFLK AKIAILCTKG FEIMDLTDFR
SATVPQRDDP RMERLARRCE SCKPIGMFRS NEDEFLLCYD EFGLYVNRHG DPSRTAMTIE
WEGTAEKAAW HPPYVLLFDT RFIEVRHVET GRLVQIIPGN DVRCIWDGRS SSSNMNLVTP
GRDGWTENGL NQEARVHGVM NAPEAVRTGG MGPQRGNRAI AQHVFELVPT VPLYLPGSLH
SPSNSAYFPA SNGPLSNSPP HSPRMTPVNN RW
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