ID A0A165T6F7_9GAMM Unreviewed; 718 AA.
AC A0A165T6F7;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KZX57006.1};
GN ORFNames=A3709_04335 {ECO:0000313|EMBL:KZX57006.1};
OS Halioglobus sp. HI00S01.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Halioglobus.
OX NCBI_TaxID=1822214 {ECO:0000313|EMBL:KZX57006.1, ECO:0000313|Proteomes:UP000077184};
RN [1] {ECO:0000313|EMBL:KZX57006.1, ECO:0000313|Proteomes:UP000077184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HI00S01 {ECO:0000313|EMBL:KZX57006.1,
RC ECO:0000313|Proteomes:UP000077184};
RA Sosa O.A.;
RT "Microbial cycling of marine high molecular weight dissolved organic
RT matter.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZX57006.1}.
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DR EMBL; LWEE01000110; KZX57006.1; -; Genomic_DNA.
DR RefSeq; WP_066055706.1; NZ_LWEE01000110.1.
DR AlphaFoldDB; A0A165T6F7; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000077184; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000077184}.
FT DOMAIN 322..497
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 500..600
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 718 AA; 77189 MW; A049FF1A95014439 CRC64;
MSYIRLEKDA DGIVDLIFDQ EGKSVNVMGE EYAEAMPKAL DELEAMGDEL KGLYIRSGKP
GQFFAGGDIT LMLEMDLNPS QEEREEMYRG LLDAKEPLAR IERLGVPVAV GINGPALGGG
YEIALACHHR IALDSPKVKV GLPEAMLGLL PGAGGIVRMT RMLGMQEALG LISQGKQLVA
AKALEKGLIH ELAADEEAMA AQAKAWIKAN SDAKQPWEQP GYSIPGGGPE DEATQGLTYF
GPVNVMNQTK GNMTAPQVII AAVIDTARVD YVTAHKIEAR YFQRLLLDQV SRNMMTTFFV
QMNALDAGAS RPEGIAKTEV KKLGILGAGV MGAGIAFNAA KVGMDVVLKD LTQENADKGK
AYAASACEKS RRIDEQQAEE ILGRIQPTAD VAELADCDLV IEAVFENRDV KAAVTRETEA
VLGEQAVFAS NTSALPITEL AQASVRPQNF IGMHFFSPAE RMPLVEIITG EQTSDECLAW
AFDLAQKMGK KPIVVKDAPG FFTTRVIGQT ITQGQRMLAE GVNPALIENG AAFNGSPMGP
LETLDTISLE TAYHAANQQR VDAEARGEQV EPSAESEVIR IMVEEAERVG QAKGAGFYDY
DDKGKKVATW AGLKALFAKD GYKDVPYQDV KDRLLFSQVL EAIRIMEEGV LTSVGDGNIG
SIMGIGFPPH TGGVYQCVNA YGVQAFADRA KELAAAYGEA FEPPQLLLDM AADGRTFG
//
