ID A0A165UBU1_9AGAM Unreviewed; 766 AA.
AC A0A165UBU1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=ELMO domain-containing protein {ECO:0000259|PROSITE:PS51335};
GN ORFNames=NEOLEDRAFT_1154882 {ECO:0000313|EMBL:KZT27925.1};
OS Neolentinus lepideus HHB14362 ss-1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Neolentinus.
OX NCBI_TaxID=1314782 {ECO:0000313|EMBL:KZT27925.1, ECO:0000313|Proteomes:UP000076761};
RN [1] {ECO:0000313|EMBL:KZT27925.1, ECO:0000313|Proteomes:UP000076761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB14362 ss-1 {ECO:0000313|EMBL:KZT27925.1,
RC ECO:0000313|Proteomes:UP000076761};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV425560; KZT27925.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A165UBU1; -.
DR STRING; 1314782.A0A165UBU1; -.
DR InParanoid; A0A165UBU1; -.
DR OrthoDB; 1473500at2759; -.
DR Proteomes; UP000076761; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771:SF56; CED-12; 1.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000076761};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 352..508
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 86098 MW; 3E14B4469E6D8F6E CRC64;
MANNSNARSN ASTTGANGAS RPKSLLVPTN SVTTKDGVTV RARIEPTLTV DDVIRQLCLN
LQLRDPPGMF ALRDETDELV TNDNLRKKIK GRVHLKLVNS PSLEAVDVVE KLSLRDERTL
RKTLFSLQKF IREEQFANEF LQRDGLSELL DVISVSHGNT LAYALLAMQN LMDLDHGWSN
LDNSFIFRVV QILSSPQSLI NVCRPATAIL KKLVEADPHS APGPLMASSS RSPPSVPPGS
VYRYGFDAVF EQMRREKGML ETVVSRLGSA DTSMILYSMM LINSLLSHAT DARWEEFTNE
LEKLNVRKAV IRVMSSHTIE DLTSCILDFQ ANMIRVTYRK KMTLVEPAAE YSHAAALKSI
WSASKLQEEL DNEGQPQRWR LLGFGSEDIT HEFRDAGILG LYCLKHFAKS DPESFSKMVL
EQLSRPAERR CPIARASNEI VELLSEHWAI FAPGYSTSTT FQPFFLNFLK VHALALNFFL
RMWSESGAAA DDFPRVVALT RSQVKVALRQ ENVRAWHEVE HDFNESEYRA VRDRQMKELE
MEDDLMSKAP MRNLSAKLYK ESYEFVRQQR IQCLLQGSWF VNAMPSSSPI SRDTLRKPSR
PWRFMRLDNG LKYLHFVDST VKFPVRNGLE DLPDRIDIAQ ITEVATGTCA APPNMLRDQT
DLPPTSPTSP SSLSFSLLTA DGSSLSDQIA PDQSRWADWT DGLNMLRRDG GHVASQETAG
FVKALTDIGL KIKLLDLTGE RVDIPSGLVA GPPPTNTDFF FSDLYD
//
