ID   A0A165WYY2_9AGAM        Unreviewed;      1028 AA.
AC   A0A165WYY2;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=3'-5' exonuclease {ECO:0000256|ARBA:ARBA00040531};
DE   AltName: Full=Werner Syndrome-like exonuclease {ECO:0000256|ARBA:ARBA00042761};
GN   ORFNames=SISSUDRAFT_1067573 {ECO:0000313|EMBL:KZT31665.1};
OS   Sistotremastrum suecicum HHB10207 ss-3.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Trechisporales; Trechisporales incertae sedis; Sistotremastrum.
OX   NCBI_TaxID=1314776 {ECO:0000313|EMBL:KZT31665.1, ECO:0000313|Proteomes:UP000076798};
RN   [1] {ECO:0000313|EMBL:KZT31665.1, ECO:0000313|Proteomes:UP000076798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HHB10207 ss-3 {ECO:0000313|EMBL:KZT31665.1,
RC   ECO:0000313|Proteomes:UP000076798};
RX   PubMed=26659563; DOI=10.1093/molbev/msv337;
RA   Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA   Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA   Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA   Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT   "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT   Insights into the Origins of Lignocellulose Decay Capabilities.";
RL   Mol. Biol. Evol. 33:959-970(2016).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; KV428496; KZT31665.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A165WYY2; -.
DR   STRING; 1314776.A0A165WYY2; -.
DR   Proteomes; UP000076798; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd06141; WRN_exo; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR046616; DUF6729.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR   PANTHER; PTHR13620:SF109; WERNER SYNDROME-LIKE EXONUCLEASE; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF20499; DUF6729; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076798}.
FT   DOMAIN          43..206
FT                   /note="DUF6729"
FT                   /evidence="ECO:0000259|Pfam:PF20499"
FT   DOMAIN          409..570
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF01612"
FT   REGION          716..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..746
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1028 AA;  115461 MW;  27843C2DB40C9A22 CRC64;
     MPKWLYNYFA DTISRMIMRK EVDDHRKYAT PLIFSNTHNV PASFWINPPE PVVVLATGKM
     DPTLLYRPPI FLWLPHFYAQ LKCPACQKPL EKCGALRPRR IVDLENCFYI VAWRYRCTSQ
     GGCRKAFAGW GQCLLASLPA HIRLAFPAML SHRSGLSHCV INHLRVANQH KMGPAGCQSL
     LFELHTLRFN ILHNQYLEVL MERALEAHKP QGATVTASYM FPRAPEFGNF GDPDRYAGFV
     PSETYLTAML NRAIERDEPD ANQHTSCLAP DQLAIDDSFK VVKHIAKIDG IPVFNALWTL
     MDSRYIRCQV LTLTKSHEER SGPFMELANT VDRFGFSDPQ ICYSDDPKKD ERLVYSAFPS
     MASDLVLVPS LSGLDPFQSP EDIEVIHLRN SGLIEACMAS MISTASDNAT PLCVSLDAEW
     NISRPTGVSI LQLLFHSSPS VVYIIHVHQL KQLPPSLLRL LISGNFYKIG SSVKGDLTRL
     QNQFPALCLD NHAGCIDLKR YAIELGILST TESGSLDSLT RKLLGTYLPK DENIRQCDAW
     EDQKLRTELE EYAVRDVCAS FRIFEKMQEI AQNHHVQATT PANTRVALLT HAGGEIAAYG
     FISPNQTAVL DGIRVRVPTK SRVIIEIDEL MIPSAAAILY LLPQATRSRK TKSGCQRLGD
     IQGASGGTNF SLVVPIALLI QDNGMTNRQS RGVGHETNTR PDPIIQDIGS VEAPYHALHN
     DNSDEGIEQP GISEHDSDDD PHEMDSLENQ STATAPAPDN VPPIIDSEIT DTVDKIIAAV
     DAPNDTHTRI KKDIFHAFHM IPLPINHGTR ATFLRIFRDH MMRWDPVIKK QIETFCQDKF
     KLSFNQMLIR YPRFITTRIP RFVPSPSVLV PALQYVINHF ADSQDAKTGA PLFNQVAHEK
     AAAVVELARQ GYLSDIDGLP VYEKAGVDQT WYNLQAFAKH IYNADWEYHH NLGLINRTSF
     LLNYLSDFID GAQSYSDWCN GDLYETSPET FGICAFPETL RNRLNMQPFS FAAAEQFKLK
     ESKGIPEP
//