ID A0A166C9E9_9AGAM Unreviewed; 683 AA.
AC A0A166C9E9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=SISSUDRAFT_1048761 {ECO:0000313|EMBL:KZT37220.1};
OS Sistotremastrum suecicum HHB10207 ss-3.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Trechisporales; Trechisporales incertae sedis; Sistotremastrum.
OX NCBI_TaxID=1314776 {ECO:0000313|EMBL:KZT37220.1, ECO:0000313|Proteomes:UP000076798};
RN [1] {ECO:0000313|EMBL:KZT37220.1, ECO:0000313|Proteomes:UP000076798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB10207 ss-3 {ECO:0000313|EMBL:KZT37220.1,
RC ECO:0000313|Proteomes:UP000076798};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV428088; KZT37220.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A166C9E9; -.
DR STRING; 1314776.A0A166C9E9; -.
DR Proteomes; UP000076798; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000076798};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 211..404
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 445..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 626..656
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 683 AA; 72460 MW; 2ADF803023C0B66B CRC64;
MAASTTQYAY RAQKVHGRVG SGPDYGSLEA FEATARTFQY SPDGRYFGYA LSDVVRVLQV
DTPESTLVQE FAIPNIVELN FSPRSTFLST WERPAKLEEG QQHKNHRVFS LATGSQLTSF
TQKSQDSWDL QYTSSESHAI RLVGPEIQVF EPADWEKGIV DKLRVEGCSS VTLSPGLNPS
LAVFVGEKKG APASVKIYGL LTLASPPTCQ KTFYKADRTQ IKWNNLGTQV LVLTQTEVDK
TNKSYYGETG LYLLSAAGNF DCRVTLDKEG PIHDFAWSPN SKEFGVVYGY MPAKAVLFDQ
RVRTLHDFGS APYNFISFNP QARLIALAGF GNLAGQVSIF DRRTLQKVTT ISAPNTSHCS
WSPDGRFLLT ATLSPRLRVD NGVKIWHCTG PLIHIQPIDE LYQVSWKPFV GPPPVFPATI
PTAPKPSSAA EAIVVSTPPV ASDGVVKAYR PPGARGGATP SIFKREDEGG MKISPSGSPS
STPGPPGSGR YSRDGRDPRN GGQVNGNGIA NGGRRYVPGA APSPPIGNGN GHGSPSPGPK
NNKKKKGKAG GPGGPGGGGA GTPPTGPGTP QESAGGEIAL DAPVPVPVNA MRGNVPGLIA
GVAGLNIPGV EDATVPPTPS EEGGNLDTVA KKVRNLTKKL KAIEELKEKA KRGERLEATQ
VRKMDGEADI RKELAALGGA GAT
//
