ID A0A166E5P2_9EURY Unreviewed; 556 AA.
AC A0A166E5P2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Acetyl-coenzyme A synthetase {ECO:0000313|EMBL:KZX16306.1};
DE EC=6.2.1.1 {ECO:0000313|EMBL:KZX16306.1};
GN Name=acsA_1 {ECO:0000313|EMBL:KZX16306.1};
GN ORFNames=MBCUT_09190 {ECO:0000313|EMBL:KZX16306.1};
OS Methanobrevibacter cuticularis.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=47311 {ECO:0000313|EMBL:KZX16306.1, ECO:0000313|Proteomes:UP000077275};
RN [1] {ECO:0000313|EMBL:KZX16306.1, ECO:0000313|Proteomes:UP000077275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11139 {ECO:0000313|EMBL:KZX16306.1,
RC ECO:0000313|Proteomes:UP000077275};
RA Poehlein A., Seedorf H., Daniel R.;
RT "Genome sequence of Methanobrevibacter cuticularis DSM 11139.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZX16306.1}.
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DR EMBL; LWMW01000095; KZX16306.1; -; Genomic_DNA.
DR RefSeq; WP_067259446.1; NZ_LWMW01000095.1.
DR AlphaFoldDB; A0A166E5P2; -.
DR STRING; 47311.MBCUT_09190; -.
DR PATRIC; fig|47311.3.peg.1013; -.
DR OrthoDB; 193284at2157; -.
DR Proteomes; UP000077275; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KZX16306.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077275}.
FT DOMAIN 40..414
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 464..542
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT COILED 137..164
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 556 AA; 63891 MW; 959EDF66D2164555 CRC64;
MSSLLKEFVN RTDFDSYEDF KNNFDFKVPK NFNFAYDVVD RYAKEDPEKI ALIWCNDFNE
EKIFTFKDMK KYSDKAANFF KTQGIEKGDA VMLTLKNRFE FWFCIIGLHK IGAIPVPATH
MLKTKDIVYR IDKASIKMIV SIDNEELISE YEKAEKELNI KLKKISVGEK SLENWKNFSE
NIKNCSGDFQ RPTGPQSTEN KDISILYFSS GTTGQPKMVK HDFRYPLAHI ITSKYWHDAI
EDGIHHTSAD TGWMKAVWGG LYGQWIVGTS VFIYDYDRFD AVNLVEKIEK YKINTFCAPP
TIYRFLIKED LSKYDFSNLK YITTAGEPLN PEVYNKVQEI FGLKLKEGFG QTETVISVAN
FVWMEPKPGS MGKPAPRFNV ELLDTEGNIA DIGDEGEICI ETSSMPPGLF QGYYRNQKKT
DEVWYDGYYH SGDTAWKDED GFLWFVGRND DIIKSSGYRI GPFEVESALI SHPSVLECAI
TGAPDQVRGQ IVKATIVLTK GYKPSDGLKK ELQDHVKKVT APYKYPRLIE FVDELPKTIS
GKIRRIQIRN EDKNKS
//
