ID A0A166ENS1_9EURY Unreviewed; 588 AA.
AC A0A166ENS1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Multidrug export protein MepA {ECO:0000313|EMBL:KZX16852.1};
GN Name=mepA_5 {ECO:0000313|EMBL:KZX16852.1};
GN ORFNames=MBCUT_04820 {ECO:0000313|EMBL:KZX16852.1};
OS Methanobrevibacter cuticularis.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=47311 {ECO:0000313|EMBL:KZX16852.1, ECO:0000313|Proteomes:UP000077275};
RN [1] {ECO:0000313|EMBL:KZX16852.1, ECO:0000313|Proteomes:UP000077275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11139 {ECO:0000313|EMBL:KZX16852.1,
RC ECO:0000313|Proteomes:UP000077275};
RA Poehlein A., Seedorf H., Daniel R.;
RT "Genome sequence of Methanobrevibacter cuticularis DSM 11139.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZX16852.1}.
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DR EMBL; LWMW01000085; KZX16852.1; -; Genomic_DNA.
DR RefSeq; WP_067258488.1; NZ_LWMW01000085.1.
DR AlphaFoldDB; A0A166ENS1; -.
DR STRING; 47311.MBCUT_04820; -.
DR PATRIC; fig|47311.3.peg.559; -.
DR OrthoDB; 214119at2157; -.
DR Proteomes; UP000077275; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002528; MATE_fam.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF01554; MatE; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000077275};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 471..586
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF13581"
SQ SEQUENCE 588 AA; 64673 MW; ECF5AB4C14ADEE0A CRC64;
MCVIIKNTLT NNYLILKSFK SYLFLSIIGL ISATLGIVVD GLVIGNFLGN DGMVAYGLVS
PVFILILAFA TVFGNGGTIL SSNYIGREER EKVNSSFTMA CLIGLITSIV ITAFSPFYVD
YLSVLLGATG ALTRMASDFM FGLILGTISL IFSQILFLYT RLDNNPNLGL ISIIITTVFN
ITLDILFVTV LHLGIFGIGI ATSISYGLGA LVLCTHFFTK NNTLYFSKIH DFNQAIDIIK
IGLPTALNRV FTMARTIVTN NVALWVGGVI VMGALTIQSS INQLLSAVAM GVGMTTMLLG
GIFYGEEDRR SLADLLKISI KWGLYIIVPI SVFVIVFAPF LVGLFGKNPE VLPTATVSLR
LFALSLPPSL IGVVFLNFYS SINNTTMANY IGFAHSFLLI SLFAVVLTPI IGDTGLWLCF
FLGETFTLIG LIILIRTKTG RWPRKINDFL ILDDSFEKNI KNSISISIGN DMDQVMELSN
KIYSFIDKYP QYEDKLKKIA LCVEEMAGNI VEHGFESSKQ HYIDIRILLT EGGVIFRIRD
DGKPFNPIEY GNDMSISKNK LGISIVRKIA KDISYRNTIG LNNLTIVL
//
