ID A0A166EWY5_DAUCS Unreviewed; 1333 AA.
AC A0A166EWY5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DCAR_007914 {ECO:0000313|EMBL:KZN07077.1};
OS Daucus carota subsp. sativus (Carrot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae;
OC Daucus; Daucus sect. Daucus.
OX NCBI_TaxID=79200 {ECO:0000313|EMBL:KZN07077.1, ECO:0000313|Proteomes:UP000077755};
RN [1] {ECO:0000313|EMBL:KZN07077.1, ECO:0000313|Proteomes:UP000077755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DH1 {ECO:0000313|Proteomes:UP000077755};
RC TISSUE=Leaf {ECO:0000313|EMBL:KZN07077.1};
RX PubMed=27158781; DOI=10.1038/ng.3565;
RA Iorizzo M., Ellison S., Senalik D., Zeng P., Satapoomin P., Huang J.,
RA Bowman M., Iovene M., Sanseverino W., Cavagnaro P., Yildiz M.,
RA Macko-Podgorni A., Moranska E., Grzebelus E., Grzebelus D., Ashrafi H.,
RA Zheng Z., Cheng S., Spooner D., Van Deynze A., Simon P.;
RT "A high-quality carrot genome assembly provides new insights into
RT carotenoid accumulation and asterid genome evolution.";
RL Nat. Genet. 48:657-666(2016).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZN07077.1}.
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DR EMBL; LNRQ01000002; KZN07077.1; -; Genomic_DNA.
DR RefSeq; XP_017235191.1; XM_017379702.1.
DR EnsemblPlants; KZN07077; KZN07077; DCAR_007914.
DR GeneID; 108209021; -.
DR Gramene; KZN07077; KZN07077; DCAR_007914.
DR KEGG; dcr:108209021; -.
DR OMA; WFISADA; -.
DR OrthoDB; 657067at2759; -.
DR Proteomes; UP000077755; Chromosome 2.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000077755};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..99
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 162..383
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1333 AA; 150991 MW; EC8BA26F2D3FB17C CRC64;
MADIFLSASV TVLFDRLASA DLLSLAKQVR IQDELKRWKD TLSRIQVVLA DAEEKQFTNR
SVRLWLLDLQ HFSYDLDDTL DILETELLQR SVSGSNNSFS LMNVLFDHYA GSNISNISTR
LDNIIKQKDG LDLKENVGFT PISATFRRWP STSLVESHVY GREKDKEMII DMLMKDDGTD
SDKFVVPIVG MGGLGKTTLA QLVYNDEEVD RNFELKAWAC VSDNLDIPGV TRAILESLAS
QSCNLNDLNT LQVTLRQKLS GKKFLLVLDD IWSQNYEEWD LLRRPFLAGA PGSKIIVTTR
ISDVAKMLSH NGAHHLNQLE PSHCLSLLAR HALGKDNFVE HPDLKEIGEN ILKKCKGLPL
AIKMLGGLLR TKQFPNQWGD ILKSKILDLP EQSGGILPAL RLSYRHLLPH LKQCFAFCSI
YPKDYEFDKE KLIKLWMAEG LLPQSSTTKQ SEDFGCEYFD ELLSRSFFQQ SATCKSKYVM
HDLINDLAVY VSGERCFRLE DNWNNTDDPR RVRHSSYITQ RFNNFEKFEI LHKFKSLRTF
IRLDIHYGYT THLSNKVLKN LLPKLKFLRL LSLNGNNIMA LPASIGDLKH LRYIDLSYTS
IRTLPDSVTA LYNLQTLLVH GCRNLCKFPV GFENLISLRH LDNADTGELL EMPCGIGKLT
NLQTLSKFVV AKGGGLRLRE LRDLKFLRGK LCITGLHNVT GAGDAKEARL GDKQDLDELI
LEWGTNLNKS SCRNLDIDVL GDLEPQKNLA KLAIYYFSGI RLPDWIADPS FTKLQEINLI
GCWRCASLPP LGQLHMLKVL SIREMPELRS LGVGSSGLDF SSLEKLTFDS MPEWNEWFYF
DRNGEKVSPQ FPSLRELTLQ KCPKLINIPK LPLPSLCLLK LEDCPVNILK SLANFTSLTT
LTIISMKELP CLSKEYMQFC GALTYLEINN CSELVTVWGT GVAFAELSCL KEMKVVSCRR
LISFSETRQA FPRNLRSLSI LQCDHLKDFP DMPSLIKLSI EKCQSLHSFA AVTLPMLQQL
DIKDCAALVS MPDYEPGISC LQELNVSKCG SLRWWPMDKS PTALEKLSIS KNCRNLEIGI
VLQWMTTRMP SLLELDIRNS GEVLVKIVNS EQHRLASLVK LVISKCKTFE SFRAKGWPPI
PHLKSLSIGS CKNLRYIPLD QIQSLESLDI CYCPKLESFP DGDLPRKLTK LTMRGCGELL
KPLSEWSLHK LPSLESFSIS GGFSRLVSIS DDKSDAWLPQ SLKQLSIGEF ESLESLGKGL
ENVRSLEHLL VWDCPKLRCL PGGNVVSSLL SLEIRDCPIL ENKCLPENKG SYWPIISDIP
RVKLSHRYIH DEE
//
