ID A0A166FCY0_DAUCS Unreviewed; 739 AA.
AC A0A166FCY0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=DCAR_008468 {ECO:0000313|EMBL:KZN07631.1};
OS Daucus carota subsp. sativus (Carrot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae;
OC Daucus; Daucus sect. Daucus.
OX NCBI_TaxID=79200 {ECO:0000313|EMBL:KZN07631.1, ECO:0000313|Proteomes:UP000077755};
RN [1] {ECO:0000313|EMBL:KZN07631.1, ECO:0000313|Proteomes:UP000077755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DH1 {ECO:0000313|Proteomes:UP000077755};
RC TISSUE=Leaf {ECO:0000313|EMBL:KZN07631.1};
RX PubMed=27158781; DOI=10.1038/ng.3565;
RA Iorizzo M., Ellison S., Senalik D., Zeng P., Satapoomin P., Huang J.,
RA Bowman M., Iovene M., Sanseverino W., Cavagnaro P., Yildiz M.,
RA Macko-Podgorni A., Moranska E., Grzebelus E., Grzebelus D., Ashrafi H.,
RA Zheng Z., Cheng S., Spooner D., Van Deynze A., Simon P.;
RT "A high-quality carrot genome assembly provides new insights into
RT carotenoid accumulation and asterid genome evolution.";
RL Nat. Genet. 48:657-666(2016).
CC -!- FUNCTION: May be involved in the transport of sterols.
CC {ECO:0000256|ARBA:ARBA00003361}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZN07631.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LNRQ01000002; KZN07631.1; -; Genomic_DNA.
DR RefSeq; XP_017234876.1; XM_017379387.1.
DR AlphaFoldDB; A0A166FCY0; -.
DR EnsemblPlants; KZN07631; KZN07631; DCAR_008468.
DR GeneID; 108208826; -.
DR Gramene; KZN07631; KZN07631; DCAR_008468.
DR OMA; PCDQNEG; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000077755; Chromosome 2.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF88; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2B; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15413; PH_11; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000077755};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 38..160
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 643..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..681
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 83953 MW; F6C065CD8A19333B CRC64;
MRVKQMYHPL CCLPLENTAI GNQSPEISTS GIAGSESSSS FAGVLSKWTN YSKGWRSRWF
VLRHGVLSYS KTHRLENFAT PPPESDVSLI GPVPSVNPTT TSRHKNTQSG IIHLKISSFR
ESRSDNRRFY IFTATKTLHL RTHSKKERVA WIRALVSTRC LYSLRPLNDN LSLVPSNLSL
STAKLKNCLL ENGISEVLVK DCEQIMISEF SDIEGQVKVL CEERSNLLDT LRQLEAANFE
AETSGATDGD YQLTKFEYSS SSLGRGKFAG YSTTESSDDA GKQELDEVSD EEEAQFFDTE
ECFPEATTSS GSIGVDYMAK SIDCQINNIG SASSKMDINA SGYPPFRRRN KLPDPVEKEK
GVSLWAMIKD MVGKDLSRVC LPVYFNEPIS TLQKCFEELE YSHLLDQAYE YGKEGNSLLR
ILSVAAFAVS GYASTDGRHC KPFNPMLGET YEADYPEKGV RFFSEKVSHH PTLIACHCEG
KGWKFWGDSN LRSKFWGRSI QLDPLGTLTL EFDDGEIFQW SKVTTTIYNL ILGKLYCDHH
GTMQICGNRQ YSCTLKFKEQ SILDRNPRQV HGFVEDDTGE KVATLYGKWD EHMYYTLGDR
VSKTKDFSSA SLLWKRSETP PNLTRYNLTP FAITLNEIAP GLKEKLPPTD SRLRPDQRHL
ENGEYDKANE EKQRLETRQR MSRKLQENGW RARWFNRESE DGPFRYAGGY WEAREKRKWD
DCADIFGQFC EDLSSTKGS
//
