ID   A0A166I9L5_9MICO        Unreviewed;       167 AA.
AC   A0A166I9L5;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE            EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
GN   Name=gmd_2 {ECO:0000313|EMBL:KZX22001.1};
GN   ORFNames=ACH61_00855 {ECO:0000313|EMBL:KZX22001.1};
OS   Rathayibacter tanaceti.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Rathayibacter.
OX   NCBI_TaxID=1671680 {ECO:0000313|EMBL:KZX22001.1, ECO:0000313|Proteomes:UP000076717};
RN   [1] {ECO:0000313|EMBL:KZX22001.1, ECO:0000313|Proteomes:UP000076717}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-2596 {ECO:0000313|EMBL:KZX22001.1,
RC   ECO:0000313|Proteomes:UP000076717};
RA   Vasilenko O.V., Starodumova I.P., Tarlachkov S.V., Dorofeeva L.V.,
RA   Evtushenko L.I.;
RT   "Draft Genome Sequence of Rathayibacter sp. Strain VKM Ac-2596 Isolated
RT   from Leaf Gall Induced by Plant-Parasitic Nematodes.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00001937};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. GDP-mannose 4,6-dehydratase subfamily.
CC       {ECO:0000256|ARBA:ARBA00009263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KZX22001.1}.
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DR   EMBL; LIIN01000018; KZX22001.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A166I9L5; -.
DR   PATRIC; fig|1671680.3.peg.900; -.
DR   Proteomes; UP000076717; Unassembled WGS sequence.
DR   GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR006368; GDP_Man_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR   PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:KZX22001.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076717}.
FT   DOMAIN          1..154
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   167 AA;  18900 MW;  F15C8B37099646AB CRC64;
     MTINYRESYG MHASSGILFN HESPRRGPEF VTRKISLAVA RIKLGLQDTL ELGNLDAKRD
     WGFAGDYVDA MWRMLQQPEG DDYVVATGET HEIREYLDIA FAHVGIEDWT PYVTQNPAFM
     RPAEVDLLIG DPAKARDVLG WEPKVSFPEL VSMMVENDLA EQSALIR
//