ID A0A166ITD3_9AGAM Unreviewed; 719 AA.
AC A0A166ITD3;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN ORFNames=SISSUDRAFT_328549 {ECO:0000313|EMBL:KZT44053.1};
OS Sistotremastrum suecicum HHB10207 ss-3.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Trechisporales; Trechisporales incertae sedis; Sistotremastrum.
OX NCBI_TaxID=1314776 {ECO:0000313|EMBL:KZT44053.1, ECO:0000313|Proteomes:UP000076798};
RN [1] {ECO:0000313|EMBL:KZT44053.1, ECO:0000313|Proteomes:UP000076798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB10207 ss-3 {ECO:0000313|EMBL:KZT44053.1,
RC ECO:0000313|Proteomes:UP000076798};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; KV428005; KZT44053.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A166ITD3; -.
DR STRING; 1314776.A0A166ITD3; -.
DR Proteomes; UP000076798; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000076798};
KW Transferase {ECO:0000313|EMBL:KZT44053.1}.
FT DOMAIN 544..718
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 432..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..525
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 79356 MW; F17D75487B7F8193 CRC64;
MAPRSSGKDK SLNDEDEVLQ AVILADSFNG RFKPLTINRP RCLLPICNAT LLDWTFEGLV
LAGVQEIFVV TRSHSEQIKE AIQKSKWSRP EANLKITPIV TAKESFSPGD ALRDIYTHGI
ITSDFVLVSG DLVSNVAIQD AVRVHKDRRK TNKDAIMTMV VRNVGGSNHR TRFVRFIPRG
ETGLFVLDPE TSECLHYEPV PASPYKTHAH IPREILVQHP EVEIRNDLLD CSIDICSVEV
PSLFQDNFDY QDIRRDFVRG ILQSDLLNRN IHCYVVNDGY AARVKDTKSY AAISKDILSR
WTFPLVPGAN YPGETNYEHQ RGNRYVPAER STVLARNCKV GRNTLIGRLS RIHDGAEMIS
STLGDEVVVG PDSVIKDSYI FDGCHIGRKC VIDQCIIGHG VRIHDRTVLR KGSIVGDGVV
LGPDVTIPEF SRISTFPFDE EDDDDDDEEK VVSPKPSDAP TKAVLGAAAH GYLWPPFSEE
EDEGADEFED FENSRFLRLG VDSSELDLSD PGSDSDSDDE DAGNASDVSE VSQPTSLAPL
GADGASVAEF LSECTQSLER AFAEGHSVDN AAVELKTLRM ASNVPLRRVK EVVVSFFVEK
IRIVDGAAEQ RKEVTKVIGR WGALLTSIGG ADGVETCAIL QAHCASTPKH MTLFGPVMAA
LYSSDVVDED DIREWHSRPE SLGRDKPAVE AANMLKCRGV GSVMLRQFDE QEDDSEDSE
//
