ID A0A166J3A2_9AGAM Unreviewed; 1062 AA.
AC A0A166J3A2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase {ECO:0000256|ARBA:ARBA00034552};
GN ORFNames=SISSUDRAFT_1038822 {ECO:0000313|EMBL:KZT44320.1};
OS Sistotremastrum suecicum HHB10207 ss-3.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Trechisporales; Trechisporales incertae sedis; Sistotremastrum.
OX NCBI_TaxID=1314776 {ECO:0000313|EMBL:KZT44320.1, ECO:0000313|Proteomes:UP000076798};
RN [1] {ECO:0000313|EMBL:KZT44320.1, ECO:0000313|Proteomes:UP000076798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB10207 ss-3 {ECO:0000313|EMBL:KZT44320.1,
RC ECO:0000313|Proteomes:UP000076798};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR EMBL; KV428004; KZT44320.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A166J3A2; -.
DR STRING; 1314776.A0A166J3A2; -.
DR Proteomes; UP000076798; Unassembled WGS sequence.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016:SF16; METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED; 1.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000076798}.
FT DOMAIN 484..753
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
FT REGION 1041..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 117468 MW; 5113046ACF4DC00A CRC64;
MAPGIDVPPK ANGVTTKQTV AKLGNFDLVK SIKVDYTDLT VSKWISSKTG LTLIHLDYEA
PIVKGYFVVR TEIFDDTGRP HTLEHLVFMG SKKYPYKGIL DHFANRGFSN GTNAWTDIDH
TAYTVATAGS QGFLQILPVY LDHILNPTLL KSGFVTEVHH IDGAGEDSGV VYSEMQGREN
TSGDLMALRM QRLLNPDGSG YRSEIGGLME VLREITVEDI RTYHSQYYVP HNLAIVVAGK
IDPAAILETL ETHVEPGLIE NGFDKGPNPP GWKRPFVETE SANRPGIPKT IQSIVEFPEK
DESTGEIAFS FVGPSPTNYL EDSALDLLGT YLTSSATAPL NKEFIETANP LCTYIYFDAN
TRVKYSDLQI IVGSVPVQHL EVFDQKLISA LTRIANEGIN MDRMSRVISR DRRKFFSALE
SAQGDAFSTN IISDYLYGDA NGKTLQPLLD DLAYYDALSH WTSDQWVELL RRYFLDSPRV
VILGKPSAGL ADRLQETEKA RIQRQIQDLG PAGLENARKE LEKAKTEHDA PIPQDILSQF
KVPDVRSISW IPVKSYQNAV PSERSAPRVI SRSDELAKHI EADGNDLPFF VQFDHVKSDF
IKIHAFLSLR SLPDHLRPYL TIYQGSFFSL PVKRASGVLS HTEVVDQLEN ETVGYSIGLG
QDGSFEEALK ISMEVETTRY SEAISWLRDL LFNSQFDEER LRVTVAKVQQ SLPELKRDGS
AVASSFSGDL LYNRNSTSQA NTLLQQIETI PKLARELEED PARVIQSFTE LRNWITKPAG
LRFSVSGNVL AVKEPRSSWA KYFTVERTPL EPIRLACETL SDLGKAPSQK AVVVSLPTIE
SSFSVHTAKS IQGWGHPEWP ALRIAVECLN ALESFLWRYI RGSGLAYGAY IGADLESGLV
SFTLYRSPNA YKAFEEGAKV VRGLADGSIP LDQTVVDAAK SSIVYGVTKA VSTPGRAAMN
SFANQALKGV SHDFNVQLLD KYQEVTIDDV RTAIKRRFLP LFDPSSSIAV VVSAPGKVEE
ISSSLTEAGF TVDNRVLEVA EDEAMEVDDG SSSDDSSGSS ER
//
