ID A0A166K2Q0_9AGAM Unreviewed; 1945 AA.
AC A0A166K2Q0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Putative polyketide synthase {ECO:0000313|EMBL:KZP21464.1};
GN ORFNames=FIBSPDRAFT_919578 {ECO:0000313|EMBL:KZP21464.1};
OS Fibularhizoctonia sp. CBS 109695.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Atheliales; Atheliaceae; Fibularhizoctonia.
OX NCBI_TaxID=436010 {ECO:0000313|EMBL:KZP21464.1, ECO:0000313|Proteomes:UP000076532};
RN [1] {ECO:0000313|EMBL:KZP21464.1, ECO:0000313|Proteomes:UP000076532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 109695 {ECO:0000313|EMBL:KZP21464.1,
RC ECO:0000313|Proteomes:UP000076532};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
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DR EMBL; KV417547; KZP21464.1; -; Genomic_DNA.
DR STRING; 436010.A0A166K2Q0; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000076532; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000076532};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 375..802
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1615..1692
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1945 AA; 211648 MW; CE81A4C86E95012E CRC64;
MSSRHPDVPV FSGQGTDFAN AARTYAQGVR DASTPAGSVL LAACFDAFRE ELSALSVEQR
VKSEIRLGEQ PHIYTGIDLL APSVQAVNNP ITSGARLFLF QVLRSSSSQS RFRDALLSPD
TETKSLGVLG FSSGVLAACV TASSLSLPAY ISYSIQAFRL QEYRRNVLIN MDSTASQLPW
SVAVFGLDQR ALEGLIADFG TRNGFRPTIT AVTAPELLTV SGHPVELQSF CASLPSSCTL
HSTNLSTLYH SATHLASARQ KILEDALLRN IRFPELSDLA APIRSTYTGE LISNTTPGSL
VELVVDMLLM QPVNWNLAVA SLKLAAGNSA FRLANYGPGL GLMRITERAL EGTASVAVDM
TLECEGKSNE RNAKHEPIAI VGMAVNMPGA PDKVKLWEAL EKGVNMCTEI PESRFRVSDY
ASSSNLQSGR SMRAHTGNFI SSASAFDAKF FKISPREARS MDPQQRILLQ VAYAALENAG
YVPDSTPSFQ RDSMGCFVGA ATRDYAENLR SDIDVYYSTG TLAAFLSGRI SYVMQFGGPS
VTVDTACSSS TVAIYQACRA ISTGDCRAAI AGGVNVITSP DMMLGLDRGH FLSPTGQCKA
FDASADGYSR GEGCGMFVLK KLSDAVAEND TILGVIRSIE VNQSGMASSI THPHPPSQIK
LFRKVMENAG IDPSRVGVVE AHGTGTQAGD PCEMESIRAV FSVNRLTQHP LHVTSIKANL
GHLEAASGAA GLAKLLLMFQ HQTIPRQILF SELNPEIAPL GLDHTVISTS HVRWPSTRGS
NRFALLNNFG AAGSNAALLL EEYQDGSPAA VEFHEHVMLG ISAKTEKALM DMRSGYITWL
QKPDNAKIAL SDIAYTVTAR RQIYPHRLAL SVCDRQELVE QLTTAIPIHV SNTADGVVFV
FSGQGSQYIG MGASLYRTCP LFRQHIDECN SILIDANFSS ILSIIMADED AEDIGLSRDA
TLEAYQTSIF AIEYSLAKVW MSWGISPVAV VGHSIGEYAA LVTAGVLALQ DALRLVARRV
QLMLEKCSPQ ASGMLAIKLP AASVARSDML EDLSIACYNS GEQCVVSGAI DKLKILKARL
DGGGYKSVIL DVPFGYHSSA MHPLLGDLKK AAERVCFSAP HIPVASNVLG KVVFAGDASV
FNAEYIVRHC REPVLFEQAI TALLNVSTAA NAAAWIELGP DATVLPMLRS HPKFPLSLLL
GSLRKGTDAW RVISGSLEKL YLSNVNVLWR EVYAHKSSVN CVDLPSYPFD TTEYWIDFQE
EMLHSSIQPA FPASSSPKYT MLFSWSQYPL QSNERTAIFL TPIAELAEFI NAHSVGGFPV
CPASVYLEQM YAGAALVVEN LAMGDGCITL RDVEFVKPLV YVENIACMVK TRVSLPFGGL
GSFTISSSYL TGDENDVIHA QGSIILKLTA DIDQKFARHL PALCRQIAAV TQPLEGAQPQ
MFSARTVYKL IFPRVVDYGE IYQAIKSLTI DPTGMEGSAT IQFPPRAKRP NELYFLHPVF
FDAMFHVAGF VANLQGEPND AYICTGMGSV RIAHGIIDEA ASYSIYCCNS WIAEEEIMFA
DIYALQLNGP RKIVAHIKGL QFRRVRLDAF KHVFPLVKQV TQVIAETCLI DSALIHPNVD
LSSLGEIFGS VLGLRIDDIN ENADLESLGL DSLTTIEAVD CFKHQSGHDI SPDIFQTYNT
IRAIQIFLSE SSQGTHAAQF TEKSNCGPRL NRIQVSSRGA PLFLVHDGSG MVDYFNRMPS
LGRDVWTIPN PHFGKDAIWP WEDLESMAQE YTGYVTSVSS GPVLVGGWSF GGVVAFEIAR
QLLKGGTDAR VLLIDSPSPI NHVPLDECLI ESITNANMRS TVSSMSWMIR AQFRFNSKSL
GMYKPLLSDG PFPKIILLRS REGFHPCGIN NVPRWLSERG DPHDVVAGWE ALVECPVRVR
DIPGHHFEPF SPSNVRRPRF MRTSN
//
