ID A0A166P454_9AGAM Unreviewed; 945 AA.
AC A0A166P454;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=FIBSPDRAFT_782937 {ECO:0000313|EMBL:KZP25696.1};
OS Fibularhizoctonia sp. CBS 109695.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Atheliales; Atheliaceae; Fibularhizoctonia.
OX NCBI_TaxID=436010 {ECO:0000313|EMBL:KZP25696.1, ECO:0000313|Proteomes:UP000076532};
RN [1] {ECO:0000313|EMBL:KZP25696.1, ECO:0000313|Proteomes:UP000076532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 109695 {ECO:0000313|EMBL:KZP25696.1,
RC ECO:0000313|Proteomes:UP000076532};
RX PubMed=26659563; DOI=10.1093/molbev/msv337;
RA Nagy L.G., Riley R., Tritt A., Adam C., Daum C., Floudas D., Sun H.,
RA Yadav J.S., Pangilinan J., Larsson K.H., Matsuura K., Barry K., Labutti K.,
RA Kuo R., Ohm R.A., Bhattacharya S.S., Shirouzu T., Yoshinaga Y.,
RA Martin F.M., Grigoriev I.V., Hibbett D.S.;
RT "Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides
RT Insights into the Origins of Lignocellulose Decay Capabilities.";
RL Mol. Biol. Evol. 33:959-970(2016).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; KV417519; KZP25696.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A166P454; -.
DR STRING; 436010.A0A166P454; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000076532; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000076532};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..52
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 74..108
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 132..163
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 174..205
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 689..886
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 405..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 102160 MW; 8FE7884182278287 CRC64;
MRFTKPAWVI HKDSAGKDDQ TAKRQSIFSV HVHPDGSRIA TGGLDSKIRI WSTKPILNLA
SELSNRPPKS LCTLTMHTGP VLAVRWAHSG RWLASGSDDQ IVMVWDLDPT ARGKVWGSDE
VNVEGWKPLK RLPGHESDVT DVAWSPGDRY LASVGLDSQV MIWCGLTLER LRKLDQHQGF
VKGVCWDPVG EFLATCSDDR TVKIWRTTDW ELEAEVSKPF EDSPGSTFFR RLSWSPDGAH
ITASNATNNK GFVFIAAVIT RNTWTSEISL VGHENTVEVA AYNPHIFLRN SSIPATTSNI
CSVVALGADD RSVSVWQTKS ARPLIVAREV FERQIMDLSW SWDGLTLYAA SSDGTLGVFN
FDPEELEGIA PHSVQEQYFQ KFAFTLPPLP EGYANIVAPY QETPTVSSRI TPPPSPTRAP
SVNPAPSQTG FGAGANGVNG GREVINQLVA KRGKKAKSSF ANTSSASIPS AFANQSASAF
APSAKSTGLP PASRSFDAGP SRTQHQTAPP SLNRQNSHSV PPPADNWPHT VYDADVDMDM
EVPIDSLSTV STLGKGKRKG AGFEDDSRPA KARTLGGDRP REAVVVRELG GVSAVGGRAP
NAWGDPHLAN ALPVAQLLSA LAVKVEGSDD MLEAKNSEGD DPTEVALVSG KHTQWLDFLP
SRVLAMTGTA SFAAVALEDG SLVVYSPNGR RLMPTLTLGS PAYAVDSSNH SLMVVTASGQ
LYSWNTKTQT SNFPPISLIT LLSSSPNCTI LSATVRPNGT PVIQCSTGAA HSYDPTLFSW
VKLSERWWAE GSDVWQSRQR GGANAARGVV AGIEGVIAAS TEDGGADKPR PSWWSSAMTL
GHLETKLHAA RVLDSPPEYK QALLVYAKKI ADEGFRGKAE ELIKELFGPV YWRPGREEGW
QSSIMGLSKR DLAKDVLSVF ARSKTLAKMA MDWQETLKKA SNGDY
//
