ID A0A166QA03_STAPS Unreviewed; 224 AA.
AC A0A166QA03;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000256|HAMAP-Rule:MF_02087};
DE Short=PLP homeostasis protein {ECO:0000256|HAMAP-Rule:MF_02087};
GN ORFNames=DD902_11765 {ECO:0000313|EMBL:PWZ73120.1}, DV961_10080
GN {ECO:0000313|EMBL:REA80686.1}, EGV54_07500
GN {ECO:0000313|EMBL:EGQ4384938.1};
OS Staphylococcus pseudintermedius.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus; Staphylococcus intermedius group.
OX NCBI_TaxID=283734 {ECO:0000313|EMBL:PWZ73120.1, ECO:0000313|Proteomes:UP000246800};
RN [1] {ECO:0000313|EMBL:PWZ73120.1, ECO:0000313|Proteomes:UP000246800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST525 1 {ECO:0000313|EMBL:PWZ73120.1,
RC ECO:0000313|Proteomes:UP000246800};
RX PubMed=29292005; DOI=10.1016/j.vetmic.2017.11.018;
RA Worthing K.A., Abraham S., Coombs G.W., Pang S., Saputra S., Jordan D.,
RA Trott D.J., Norris J.M.;
RT "Clonal diversity and geographic distribution of methicillin-resistant
RT Staphylococcus pseudintermedius from Australian animals: Discovery of novel
RT sequence types.";
RL Vet. Microbiol. 213:58-65(2018).
RN [2] {ECO:0000313|EMBL:REA80686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ST496-2 {ECO:0000313|EMBL:REA80686.1};
RX PubMed=30173756; DOI=10.1016/j.vetmic.2018.07.021;
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Methicillin-resistant staphylococci amongst veterinary personnel,
RT personnel-owned pets, patients and the hospital environment of two small
RT animal veterinary hospitals.";
RL Vet. Microbiol. 223:79-85(2018).
RN [3] {ECO:0000313|Proteomes:UP000256409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST496-2 {ECO:0000313|Proteomes:UP000256409};
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Molecular epidemiology of methicillin-resistant staphylococci amongst
RT veterinary personnel, personnel-owned pets, patients and the hospital
RT environment of two companion animal veterinary hospitals.";
RL Vet. Microbiol. 0:0-0(2018).
RN [4] {ECO:0000313|EMBL:EGQ4384938.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SPSE-18-VL-LA-PA-Ryan-0021 {ECO:0000313|EMBL:EGQ4384938.1};
RG Veterinary Laboratory Investigation and Response Network;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which is
CC involved in PLP homeostasis. {ECO:0000256|HAMAP-Rule:MF_02087}.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|PIRSR:PIRSR004848-1};
CC -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC YggS/PROSC family. {ECO:0000256|HAMAP-Rule:MF_02087,
CC ECO:0000256|RuleBase:RU004514}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWZ73120.1}.
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DR EMBL; AAXKXX010000009; EGQ4384938.1; -; Genomic_DNA.
DR EMBL; QEIT01000081; PWZ73120.1; -; Genomic_DNA.
DR EMBL; QQPC01000070; REA80686.1; -; Genomic_DNA.
DR RefSeq; WP_014614175.1; NZ_WWPQ01000054.1.
DR AlphaFoldDB; A0A166QA03; -.
DR GeneID; 66876914; -.
DR eggNOG; COG0325; Bacteria.
DR OrthoDB; 9804072at2; -.
DR Proteomes; UP000246800; Unassembled WGS sequence.
DR Proteomes; UP000256409; Unassembled WGS sequence.
DR Proteomes; UP000600220; Unassembled WGS sequence.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:UniProtKB-UniRule.
DR CDD; cd00635; PLPDE_III_YBL036c_like; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR HAMAP; MF_02087; PLP_homeostasis; 1.
DR InterPro; IPR001608; Ala_racemase_N.
DR InterPro; IPR029066; PLP-binding_barrel.
DR InterPro; IPR011078; PyrdxlP_homeostasis.
DR NCBIfam; TIGR00044; YggS family pyridoxal phosphate-dependent enzyme; 1.
DR PANTHER; PTHR10146; PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN; 1.
DR PANTHER; PTHR10146:SF14; PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN; 1.
DR Pfam; PF01168; Ala_racemase_N; 1.
DR PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Pyridoxal phosphate {ECO:0000256|HAMAP-Rule:MF_02087,
KW ECO:0000256|PIRSR:PIRSR004848-1}.
FT DOMAIN 26..221
FT /note="Alanine racemase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01168"
FT COILED 160..187
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 34
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02087,
FT ECO:0000256|PIRSR:PIRSR004848-1"
SQ SEQUENCE 224 AA; 25483 MW; 829E64641DC7539C CRC64;
MSVKTNLAEI EHTITENVTF REDPTRPHVI AVTKYVTINR AKEAYEAGIR HFGENRIEGF
LEKKAALPDD VHMHFIGSLQ SRKVKEVIND IDYLHALDRQ SLAKEISKRA EHEIKCFVQV
NVSGEASKHG IALEEVIPFI EKLVDYDHIR VVGLMTMAPY TDNEAELEDI FEKLKNKRDE
VQSLNLTYAP CTELSMGMSN DYHIATKKGA TFVRIGTRLV GKEE
//
