ID A0A166RQY2_9EURY Unreviewed; 699 AA.
AC A0A166RQY2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A4G99_14550 {ECO:0000313|EMBL:KZN23261.1};
OS Haladaptatus sp. R4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haladaptataceae; Haladaptatus.
OX NCBI_TaxID=1679489 {ECO:0000313|EMBL:KZN23261.1, ECO:0000313|Proteomes:UP000076599};
RN [1] {ECO:0000313|EMBL:KZN23261.1, ECO:0000313|Proteomes:UP000076599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R4 {ECO:0000313|EMBL:KZN23261.1,
RC ECO:0000313|Proteomes:UP000076599};
RA Mukhopadhyay S.K.;
RT "Genome sequence of halophilic archaea.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZN23261.1}.
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DR EMBL; LWHG01000029; KZN23261.1; -; Genomic_DNA.
DR RefSeq; WP_066146981.1; NZ_LWHG01000029.1.
DR AlphaFoldDB; A0A166RQY2; -.
DR STRING; 1679489.A4G99_14550; -.
DR OrthoDB; 8639at2157; -.
DR Proteomes; UP000076599; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR CDD; cd05531; POLBc_B2; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT DOMAIN 312..654
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 699 AA; 78573 MW; 22E9E2CF0B369A37 CRC64;
MVYKIDYVDG DVLTWSVTET GVNCEVDESY TPTIYVSVHG DGEFSTARAA LRDLPAVAGV
AVVDRRVSFR HDPERVLRVD VTDLTAVDSV ARTVSKWGSP GEYRCYNVDF SREFRYCLEA
GIDPLPEHEL SRMRIAIAET ELASGTVTEL TIDDETVTGS GADVLATLSA RVERADPDVL
FLNTSDLVPV LFGQAERLDV AFQLGRRPGW QQLAGESTYE SYGRVGHSPA RYNLPGRAII
DGSNTFMWNQ TNLDGCLYLV KRSGKPLQEL AWSSIGNVLT GIQIREGRER DVLVPWHSWR
HERFKTMRQL RDADRGGFTF APDVGLHENV HELDFSSLYP NIIVTRNVSP EKIRCECHAG
REDVPGIGYS ICDERGYLPD VLEPLIEDRE GIKAEICGTE NDDRRDELAG QSSAIKWILV
SCFGYQGFSN AKFGRIECHE AINAFAREIL LETKAVLEAN GWRIVHGIVD SVWVTPIEGE
ERTPLSELAT RISAQVEIRL EHEAHYDWIA FVPLRDSDAG ALTKYFGKVA GEDEYKYRGI
ECRQRSTPSY IDEAQKALIR AVDEHRDPEA VCEELRSWID RLERGAVDPS ELVITNRVSK
NREEYTQSTR SVAALERAAE LGLARSPGQS VSYVVVDDAK KSRERVALAV EKPTEYDSEF
YRVSLIRGAE SVLSPLGWRE KHIERFLSGH DERSLESFL
//
