ID A0A166SDK2_STAPS Unreviewed; 207 AA.
AC A0A166SDK2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Guanylate kinase {ECO:0000256|ARBA:ARBA00016296, ECO:0000256|HAMAP-Rule:MF_00328};
DE EC=2.7.4.8 {ECO:0000256|ARBA:ARBA00012961, ECO:0000256|HAMAP-Rule:MF_00328};
DE AltName: Full=GMP kinase {ECO:0000256|ARBA:ARBA00030128, ECO:0000256|HAMAP-Rule:MF_00328};
GN Name=gmk {ECO:0000256|HAMAP-Rule:MF_00328,
GN ECO:0000313|EMBL:QQM97384.1};
GN ORFNames=DD902_11970 {ECO:0000313|EMBL:PWZ73069.1}, DV961_10215
GN {ECO:0000313|EMBL:REA80712.1}, EGV54_07635
GN {ECO:0000313|EMBL:EGQ4384965.1}, JGZ15_07595
GN {ECO:0000313|EMBL:QQM97384.1};
OS Staphylococcus pseudintermedius.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus; Staphylococcus intermedius group.
OX NCBI_TaxID=283734 {ECO:0000313|EMBL:REA80712.1, ECO:0000313|Proteomes:UP000256409};
RN [1] {ECO:0000313|EMBL:PWZ73069.1, ECO:0000313|Proteomes:UP000246800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST525 1 {ECO:0000313|EMBL:PWZ73069.1,
RC ECO:0000313|Proteomes:UP000246800};
RX PubMed=29292005; DOI=10.1016/j.vetmic.2017.11.018;
RA Worthing K.A., Abraham S., Coombs G.W., Pang S., Saputra S., Jordan D.,
RA Trott D.J., Norris J.M.;
RT "Clonal diversity and geographic distribution of methicillin-resistant
RT Staphylococcus pseudintermedius from Australian animals: Discovery of novel
RT sequence types.";
RL Vet. Microbiol. 213:58-65(2018).
RN [2] {ECO:0000313|EMBL:REA80712.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ST496-2 {ECO:0000313|EMBL:REA80712.1};
RX PubMed=30173756; DOI=10.1016/j.vetmic.2018.07.021;
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Methicillin-resistant staphylococci amongst veterinary personnel,
RT personnel-owned pets, patients and the hospital environment of two small
RT animal veterinary hospitals.";
RL Vet. Microbiol. 223:79-85(2018).
RN [3] {ECO:0000313|Proteomes:UP000256409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST496-2 {ECO:0000313|Proteomes:UP000256409};
RA Worthing K.A., Brown J., Gerber L., Abraham S., Trott D., Norris J.M.;
RT "Molecular epidemiology of methicillin-resistant staphylococci amongst
RT veterinary personnel, personnel-owned pets, patients and the hospital
RT environment of two companion animal veterinary hospitals.";
RL Vet. Microbiol. 0:0-0(2018).
RN [4] {ECO:0000313|EMBL:EGQ4384965.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SPSE-18-VL-LA-PA-Ryan-0021 {ECO:0000313|EMBL:EGQ4384965.1};
RG Veterinary Laboratory Investigation and Response Network;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QQM97384.1, ECO:0000313|Proteomes:UP000595859}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HSP080 {ECO:0000313|EMBL:QQM97384.1,
RC ECO:0000313|Proteomes:UP000595859};
RA Ferrer L., Perez D., Fonticoba R., Vines J., Fabregas N., Madronero S.,
RA Meroni G., Martino P., Martinez S., Cusco A., Migura L., Francino O.;
RT "Whole genome sequencing and de novo assembly of Staphylococcus
RT pseudintermedius: a novel pangenome approach to unravel pathogenesis of
RT canine pyoderma.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC {ECO:0000256|ARBA:ARBA00003531, ECO:0000256|HAMAP-Rule:MF_00328}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:456216; EC=2.7.4.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000283, ECO:0000256|HAMAP-
CC Rule:MF_00328};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00328}.
CC -!- SIMILARITY: Belongs to the guanylate kinase family.
CC {ECO:0000256|ARBA:ARBA00005790, ECO:0000256|HAMAP-Rule:MF_00328}.
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DR EMBL; AAXKXX010000009; EGQ4384965.1; -; Genomic_DNA.
DR EMBL; QEIT01000083; PWZ73069.1; -; Genomic_DNA.
DR EMBL; CP066884; QQM97384.1; -; Genomic_DNA.
DR EMBL; QQPC01000070; REA80712.1; -; Genomic_DNA.
DR RefSeq; WP_014614147.1; NZ_WWPQ01000028.1.
DR AlphaFoldDB; A0A166SDK2; -.
DR GeneID; 77325274; -.
DR eggNOG; COG0194; Bacteria.
DR OMA; EWAVVHG; -.
DR OrthoDB; 9808150at2; -.
DR Proteomes; UP000246800; Unassembled WGS sequence.
DR Proteomes; UP000256409; Unassembled WGS sequence.
DR Proteomes; UP000595859; Chromosome.
DR Proteomes; UP000600220; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004385; F:guanylate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00328; Guanylate_kinase; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR017665; Guanylate_kinase.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03263; guanyl_kin; 1.
DR PANTHER; PTHR23117:SF13; GUANYLATE KINASE; 1.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00328}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00328};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|HAMAP-Rule:MF_00328};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00328};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00328}.
FT DOMAIN 6..185
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT BINDING 13..20
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00328"
SQ SEQUENCE 207 AA; 24033 MW; D97808E8729482C3 CRC64;
MDTEKGLLIV LSGPSGVGKG TVRKRIFDDP HTSYKYSISM TTRQMREGEQ DGVDYFFKTR
EEFEKLIEAD EFIEYAEYVG NYYGTPVQYV KDTMNAGHDV FLEIEVEGAK QVRKKFPDAL
FIFLAPPSLD HLTERLIGRG TESKEKIESR VKEAKKEVEM MNLYDYVVVN DEVDLAKDRI
QSIVEAEHLK RERIEAKYRK MLLEAKK
//
