ID A0A166T742_9ACTN Unreviewed; 459 AA.
AC A0A166T742;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dioxygenase, isopenicillin N synthase {ECO:0000313|EMBL:OAA29391.1};
GN ORFNames=UG55_100222 {ECO:0000313|EMBL:OAA29391.1};
OS Frankia sp. EI5c.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=683316 {ECO:0000313|EMBL:OAA29391.1, ECO:0000313|Proteomes:UP000077018};
RN [1] {ECO:0000313|EMBL:OAA29391.1, ECO:0000313|Proteomes:UP000077018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EI5c {ECO:0000313|EMBL:OAA29391.1,
RC ECO:0000313|Proteomes:UP000077018};
RX PubMed=27389275;
RA D'Angelo T., Oshone R., Abebe-Akele F., Simpson S., Morris K., Thomas W.K.,
RA Tisa L.S.;
RT "Permanent Draft Genome Sequence for Frankia sp. Strain EI5c, a Single-
RT Spore Isolate of a Nitrogen-Fixing Actinobacterium, Isolated from the Root
RT Nodules of Elaeagnus angustifolia.";
RL Genome Announc. 4:e00660-16(2016).
RN [2] {ECO:0000313|EMBL:OAA29391.1, ECO:0000313|Proteomes:UP000077018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EI5c {ECO:0000313|EMBL:OAA29391.1,
RC ECO:0000313|Proteomes:UP000077018};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC family. {ECO:0000256|RuleBase:RU003682}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA29391.1}.
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DR EMBL; LRTK01000002; OAA29391.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A166T742; -.
DR STRING; 683316.UG55_100222; -.
DR PATRIC; fig|683316.3.peg.225; -.
DR Proteomes; UP000077018; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009693; P:ethylene biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR026992; DIOX_N.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR47990; 2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED; 1.
DR PANTHER; PTHR47990:SF34; 2-OXOGLUTARATE-DEPENDENT DIOXYGENASE 33; 1.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF14226; DIOX_N; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Dioxygenase {ECO:0000313|EMBL:OAA29391.1};
KW Iron {ECO:0000256|RuleBase:RU003682};
KW Metal-binding {ECO:0000256|RuleBase:RU003682};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003682};
KW Reference proteome {ECO:0000313|Proteomes:UP000077018}.
FT DOMAIN 239..375
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 48944 MW; 794F0A66370573AA CRC64;
MRSNYIYPIE KSPKYRPTRR DGSASMPDLP DQDGADQDGA DRHRSTRHRS TRRAPDRDRP
GPGPGRGCLP VLDLRRYTAP ARPADRADFL AALRAACRDP GFFQLVGHGV PPSLAEDILR
VSREFFRLPA AAKLEIENVH SAHFRGYTRF GHEITRGRPD LREQIDIGDE RPPRALGPGD
PPYLRLDGPN QWPAALPALR PAVEKYLAEL GGLARVLVHA LAESLGLPAG QLDATYATDP
RSHLKLLRYL AAPGDAAAAP GDAPSAPGGP PSGYGQGVGA HKDGGFLSLV LQDELRPLHA
PPGPPGTLPA AGPGLQVADG PGRWIDAAPL PGAFVVNIGE MFELATAGYY QATVHRVTSP
PPGHERVSVA FFFGPSLSAT VTPVPLPADL LAEIPDAGPP DPDNPIFAQH GMNTLKSWLR
SHPEVTRRHY ADLTAADLTA ADLAQADHTA PTAPTGTAR
//
