ID A0A166TVT0_9EURY Unreviewed; 583 AA.
AC A0A166TVT0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Putative DNA helicase Rad25 {ECO:0000256|HAMAP-Rule:MF_01489};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01489};
GN Name=rad25 {ECO:0000256|HAMAP-Rule:MF_01489};
GN ORFNames=A4G99_23210 {ECO:0000313|EMBL:KZN26086.1};
OS Haladaptatus sp. R4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haladaptataceae; Haladaptatus.
OX NCBI_TaxID=1679489 {ECO:0000313|EMBL:KZN26086.1, ECO:0000313|Proteomes:UP000076599};
RN [1] {ECO:0000313|EMBL:KZN26086.1, ECO:0000313|Proteomes:UP000076599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R4 {ECO:0000313|EMBL:KZN26086.1,
RC ECO:0000313|Proteomes:UP000076599};
RA Mukhopadhyay S.K.;
RT "Genome sequence of halophilic archaea.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01489};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637, ECO:0000256|HAMAP-Rule:MF_01489}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZN26086.1}.
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DR EMBL; LWHG01000006; KZN26086.1; -; Genomic_DNA.
DR RefSeq; WP_066139246.1; NZ_LWHG01000006.1.
DR AlphaFoldDB; A0A166TVT0; -.
DR STRING; 1679489.A4G99_23210; -.
DR OrthoDB; 8379at2157; -.
DR Proteomes; UP000076599; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01489; Helicase_Rad25_arch; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR030882; Helicase_Rad25_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01489};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01489, ECO:0000313|EMBL:KZN26086.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01489};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01489}.
FT DOMAIN 234..383
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 435..583
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 8..35
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 583 AA; 66519 MW; A69A045EFA5F458E CRC64;
MLTADEVARV LDRSHEDANR ALERLRDERD VARLDVENDP VVWFPTEWER LADRERIVVF
PKRREIVADQ PEQFTRAQLS QFAHLTDTTR AGSYSYQVRQ EDIWSAPYDS LDNLMRTVRQ
VLPEPSPDLE AFIEGQWKRA KQFRLYTHED GYVVLQAASD DLMGNVARQK LNDNHLRAPI
ADDESWVAED KVAEVKRILY EAGYPVQDER ELETGDELPV ECALSLRDYQ REWVEEFIDL
KSGVLVGPPG SGKTVAAMGV LEAVSGETLI LVPGRELAGQ WRDELLTHTD LTREQVGEYH
GGEKNVRPVT IATYQTAGMD RHRQLFDQRR WGLIVYDECQ HIPSRVFRRS ANLQSKHRLG
LSATPVREDD KEKDIFTLIG PPIGTDWDAL FEAGFVAEPE VEIRYVGWDE ETYQGEYANA
DGRGKRQIAA TNPAKLDEIR FLLAEHPTSK ALVFVEYLEQ GDRIAEALDV PFLSGQMRHP
ERERHLQAFR DGREDTLVIS RVGDEGIDLP DAEIAIVASG LGGSRRQGAQ RAGRTMRPAG
RARMYVLATR GTREEEFARQ QLRHLASKGI RIQETVLDER DEE
//
