ID A0A166UKM1_9GAMM Unreviewed; 936 AA.
AC A0A166UKM1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Aconitate hydratase {ECO:0000313|EMBL:KZN30783.1};
GN ORFNames=N475_23925 {ECO:0000313|EMBL:KZN30783.1};
OS Pseudoalteromonas luteoviolacea DSM 6061.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=1365250 {ECO:0000313|EMBL:KZN30783.1, ECO:0000313|Proteomes:UP000076643};
RN [1] {ECO:0000313|EMBL:KZN30783.1, ECO:0000313|Proteomes:UP000076643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6061 {ECO:0000313|EMBL:KZN30783.1,
RC ECO:0000313|Proteomes:UP000076643};
RA Vynne N.G., Mansson M., Gram L.;
RT "Comparative Genomic and Metabolomic Analysis of Twelve Strains of
RT Pseudoalteromonas luteoviolacea.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-
CC aconitate + H2O; Xref=Rhea:RHEA:17941, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:57429, ChEBI:CHEBI:57872; EC=4.2.1.99;
CC Evidence={ECO:0000256|ARBA:ARBA00000118};
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZN30783.1}.
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DR EMBL; AUYB01000146; KZN30783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A166UKM1; -.
DR STRING; 43657.S4054249_14330; -.
DR PATRIC; fig|1365250.3.peg.4741; -.
DR Proteomes; UP000076643; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR Gene3D; 1.25.40.310; Aconitate B, HEAT-like domain; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015933; Aconitase_B_HEAT-like_dom.
DR InterPro; IPR036288; Aconitase_B_HEAT-like_dom_sf.
DR InterPro; IPR015929; Aconitase_B_swivel.
DR InterPro; IPR015932; Aconitase_dom2.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF4; ACONITATE HYDRATASE B; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF06434; Aconitase_2_N; 1.
DR Pfam; PF11791; Aconitase_B_N; 1.
DR SUPFAM; SSF74778; Aconitase B, N-terminal domain; 1.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000076643}.
FT DOMAIN 7..163
FT /note="Aconitase B HEAT-like"
FT /evidence="ECO:0000259|Pfam:PF11791"
FT DOMAIN 177..406
FT /note="Aconitase B swivel"
FT /evidence="ECO:0000259|Pfam:PF06434"
FT DOMAIN 411..894
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
SQ SEQUENCE 936 AA; 101154 MW; D3C2A8E4C34A5A67 CRC64;
MSLYTEYLDE IQTRKTEQGL NPKPIDSAEL LSEIIAQIKD AGHEHREDSL KFFIYNTLPG
TTSAAGVKAQ FLKEIILGEE TVAEITAEFA FELLSHMKGG PSIAVLLDLA LGNDEAVAKQ
AAEVLKTQVF LYDADTARLQ DAFKAGNAVA KDILESYAKA EFFTKLPDVA EKIEVVTFIA
GEGDISTDLL SPGHQAHSRA DRELHGQCMI TPEAQQEIVA LKEKHPNAKV MLIAEKGTMG
VGSSRMSGVN NVALWAGTQA SPYVPFINIA PVVAGTNGIA PIFLTTVDVT GGIGLDLKNW
VKKVDENGNT VTDQNGDPVL EEAYSVATGT VLTIDTKAKK LFNGEEELAD ISSAFTPQKV
EFMKAGGSYA VVFGKKLQTL AAETLGVEAP TVYAPSKEIS HEGQGLTAVE KIFNRNAVGV
ASDTPLHAGS NVRVKVNIVG SQDTTGPMTS QELEAMAAST ISPLVDGAYQ SGCHTASVWD
KKAQANIPKL MAFMNKFGLI TARDPKGIYH SMTDVIHKVL NDITVDDRAI IIGGDSHTRM
SKGVAFGADS GTVALALATG ESAMPIPDSV KVTFKGKMAE HMDFRDVVHA TQAQMLKQFG
GENVFQGRII EVHIGTLMAD QAFTFTDWTA EMKAKASICI SNDETLIKSI ELAKSRIQIM
INKGMENEAK TLQGLIDLAD ERIAGVKSGE QPALAPDDNA KYYAEVVVDL DEIVEPMIAD
PDVNNEDVSK RYTHDVIRPV SYYNDKPVDL GFVGSCMVHK GDMQIIAQML RNLEKQNGSI
EFKAPLVVAP PTYNIVDELK AEGDWEILAK YAGFEFDDEK PKTAARTKYE NILYLERPGC
NLCMGNQEKA EPGDTVIATS TRLFQGRVVA DTSEKKGESL LGSTPLVVLS TVLGRFPTMV
EYKAAVEGID LTAFTPLEEE LTTKFGSEQA VPVKVV
//