ID A0A166WYF6_9PEZI Unreviewed; 1515 AA.
AC A0A166WYF6;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
DE AltName: Full=Vacuolar carboxypeptidase Sorting receptor VPS10 {ECO:0000256|ARBA:ARBA00032705, ECO:0000256|ARBA:ARBA00032910};
GN ORFNames=CT0861_12890 {ECO:0000313|EMBL:KZL76108.1};
OS Colletotrichum tofieldiae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum spaethianum species complex.
OX NCBI_TaxID=708197 {ECO:0000313|EMBL:KZL76108.1, ECO:0000313|Proteomes:UP000076552};
RN [1] {ECO:0000313|EMBL:KZL76108.1, ECO:0000313|Proteomes:UP000076552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0861 {ECO:0000313|EMBL:KZL76108.1,
RC ECO:0000313|Proteomes:UP000076552};
RA Hacquard S., Kracher B., Hiruma K., Weinman A., Muench P., Garrido Oter R.,
RA Ver Loren van Themaat E., Dallerey J.-F., Damm U., Henrissat B.,
RA Lespinet O., Thon M., Kemen E., McHardy A.C., Schulze-Lefert P.,
RA O'Connell R.J.;
RT "Survival trade-offs in plant roots during colonization by closely related
RT pathogenic and mutualistic fungi.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZL76108.1}.
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DR EMBL; LFIV01000018; KZL76108.1; -; Genomic_DNA.
DR STRING; 708197.A0A166WYF6; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000076552; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000076552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1515
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007882063"
FT TRANSMEM 1385..1406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1435..1456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..692
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 742..1374
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1515 AA; 169921 MW; 0D318074615DCA7B CRC64;
MRLRGKAAAS WRILLSVLTL TAAVQAKDDP TIKVTTIKHP PLNLNYFEDS NIILYQDVSE
QNLYRTEDAG VTWDKVKDIP DNQASLLTMH EFDKSRAYVI TEGTEHFKTT DRGKTWQKFS
SGAPPNIFAG GDILHFHAGD PDRIIFNGAA CIGIFCDLKT MYTTDNFKSK AKFLRGNTEG
CWWAKSSDVF TTGKDDLDKQ RILCIVQDNF SPFKEDNRLL ASDNYFEKVD NKIQEFEPDM
DTNRGVQGVV NLAIVKKYLM VATSSLNTDE MALFVTDDTI KWHRAMFPTD HGHRVNQEAY
TVLESTNYSI QIDVMNTRPS NPTGVMFTSN SNGTFFTENL EHTNRNTKGH VDFEKINGVQ
GVFMLNTVKN WEEVEKDTKG ADEQVKKEVV SKITFDDGRN FHDLKSGDDQ LHLHSVTDLD
NIGRVFSSPA PGLVLGIGNK GKSLGKFGDG DVYVSDDAGV TWKKALDGPH KYEFGDQGSI
LVAVKDSNKE DIGEIRYSLD HGDSWKTASL PDDLKIKPEL LTTTQDSTSL KFLLVGRTGG
DNAKFHIIAL DFEGLHERTC KDDDLEDWHA RLDDNGKPSC LMGHKQTYRR RKKTADCFLN
QEFKDPVPVT EDCECTDADF ECDYNFVKDG DNCKKAGLIA APDNACKNAK PEDTFKGSSG
WRKIPGNTCK RKGGAQKDDP VERKCSEVVN APSAPADGKV KATQHVFKTE LKDFEKIYLE
RGESSTEVDE TIIVRPVEYA GNSMRADKQI WRTKDHGKTW DKILQDEDVR GIYPHYFFKD
VVFFTTDSKK VLYTIDRAEH FHSFEAPTKP GSSNPLSFHP DKKDWLIWVG EKCEKVNGKE
TCFKEASISR DRGDNWKTAM RYVQKCEFTG HSAYKFRDLR QIVCLAHKRE DDEKDNPKVI
VSSKDFFDED KQYHQSDVKD FATMAEFIVV AAEDKEKDGL RALASLDGVS YAEAHFPVNF
KVGHQNAYTV LDSSTHAVNL FVATETAEGR RHGSIIKSNS NGTSYVMSAQ AVNCNDEYYV
DFEKIPGLEG VALINTVANR DKRNEPKKVQ TQISHNDGSQ WAFLPPPKAD VDGKSYSCSS
SEGDEKCALH LHHYTERADK KKTFSAATAV GLMFGNGNVG SSLSSLKEAD TFMTTDAGIT
WKSVKKGAWT WQYGDQGSIV VLVQRASREN PVKTKTISYT TDEGKTWKDF TFTEKEVTVL
DISTLRSGAS RNFLIWCKDD GGEMFSVNVD FSGLTDRPCK SDENGGSDYY LWSPKHPSQP
DDCLFGHVSK YLRKKDDANC YNDARVQHLY QVQNCTCTRS DFECDYNFEL DNHKQCSLVE
GKSPISAEQW CKEHSDEVEY YEPTGYRRIP LTTCTGGQEL DKQAQVHPCA GKEDEFERRR
RTSGIAIFFA VVIPLGLAGA IGWWVYRNWN GKIGQIRLGE SPSLNNDAPW VKYPVIALSA
VVAVAAALPL VASALWRRAT SAYESVSGGG GGSWLTGRGN RRFTTRDSFA RGRGDYAIVD
DDEGELLGDD SDEEV
//
